{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,19]],"date-time":"2026-09-19T02:28:31Z","timestamp":1789784911310,"version":"4.0.1"},"reference-count":90,"publisher":"American Chemical Society (ACS)","issue":"49","license":[{"start":{"date-parts":[[2025,12,1]],"date-time":"2025-12-01T00:00:00Z","timestamp":1764547200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2025,12,1]],"date-time":"2025-12-01T00:00:00Z","timestamp":1764547200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2025,12,1]],"date-time":"2025-12-01T00:00:00Z","timestamp":1764547200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-045"}],"funder":[{"DOI":"10.13039\/501100021171","name":"Basic and Applied Basic Research Foundation of Guangdong Province","doi-asserted-by":"publisher","award":["2022A1515110592"],"award-info":[{"award-number":["2022A1515110592"]}],"id":[{"id":"10.13039\/501100021171","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100021171","name":"Basic and Applied Basic Research Foundation of Guangdong Province","doi-asserted-by":"publisher","award":["2023A1515012715"],"award-info":[{"award-number":["2023A1515012715"]}],"id":[{"id":"10.13039\/501100021171","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100010226","name":"Department of Education of Guangdong Province","doi-asserted-by":"publisher","award":["2021ZDJS097"],"award-info":[{"award-number":["2021ZDJS097"]}],"id":[{"id":"10.13039\/501100010226","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100007310","name":"Wuyi University","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100007310","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["21901013"],"award-info":[{"award-number":["21901013"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["22171014"],"award-info":[{"award-number":["22171014"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003453","name":"Natural Science Foundation of Guangdong Province","doi-asserted-by":"publisher","award":["2021A1515010344"],"award-info":[{"award-number":["2021A1515010344"]}],"id":[{"id":"10.13039\/501100003453","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Jiangmen Basic and Applied Basic Research Project","award":["202301003003140"],"award-info":[{"award-number":["202301003003140"]}]},{"name":"Shenzhen Maohua Industrial Group"},{"name":"Technology and Innovation Bureau of Longgang District","award":["RCTDPT-2019-008"],"award-info":[{"award-number":["RCTDPT-2019-008"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J. Org. Chem."],"published-print":{"date-parts":[[2025,12,12]]},"DOI":"10.1021\/acs.joc.5c02064","type":"journal-article","created":{"date-parts":[[2025,12,1]],"date-time":"2025-12-01T21:07:34Z","timestamp":1764623254000},"page":"17332-17356","source":"Crossref","is-referenced-by-count":1,"title":["Evolution of a Strategy for the Total Synthesis of Psymberin"],"prefix":"10.1021","volume":"90","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3804-9507","authenticated-orcid":true,"given":"Jia-Lei","family":"Yan","sequence":"first","affiliation":[{"name":"State Key Laboratory of Chemical Oncogenomics, Peking University Shenzhen Graduate School, Xili, Nanshan District, Shenzhen 518055, China"},{"name":"School of Pharmacy and Food Engineering","place":["Jiangmen, China"]},{"name":"Wuyi University","place":["Jiangmen, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jie","family":"Yu","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Chemical Oncogenomics, Peking University Shenzhen Graduate School, Xili, Nanshan District, Shenzhen 518055, China"},{"name":"School of Pharmacy and Food Engineering","place":["Jiangmen, China"]},{"name":"Wuyi University","place":["Jiangmen, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuhan","family":"Xiao","sequence":"additional","affiliation":[{"name":"School of Pharmacy and Food Engineering","place":["Jiangmen, China"]},{"name":"Wuyi University","place":["Jiangmen, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mingze","family":"Yang","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Chemical Oncogenomics, Peking University Shenzhen Graduate School, Xili, Nanshan District, Shenzhen 518055, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fusong","family":"Wu","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Chemical Oncogenomics, Peking University Shenzhen Graduate School, Xili, Nanshan District, Shenzhen 518055, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yian","family":"Guo","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Chemical Oncogenomics, Peking University Shenzhen Graduate School, Xili, Nanshan District, Shenzhen 518055, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2780-9761","authenticated-orcid":true,"given":"Tao","family":"Ye","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Chemical Oncogenomics, Peking University Shenzhen Graduate School, Xili, Nanshan District, Shenzhen 518055, China"},{"name":"QianYan (Shenzhen) Pharmatech. Ltd.","place":["Shenzhen, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"316","published-online":{"date-parts":[[2025,12,1]]},"reference":[{"key":"ref1\/cit1a","doi-asserted-by":"publisher","DOI":"10.1126\/science.8248801"},{"key":"ref1\/cit1b","doi-asserted-by":"publisher","DOI":"10.1002\/anie.200806121"},{"key":"ref2\/cit2a","doi-asserted-by":"publisher","DOI":"10.1021\/np500757w"},{"key":"ref2\/cit2b","doi-asserted-by":"publisher","DOI":"10.1039\/b417466f"},{"key":"ref2\/cit2c","doi-asserted-by":"publisher","DOI":"10.3390\/biom13111572"},{"key":"ref3\/cit3","doi-asserted-by":"publisher","DOI":"10.1002\/anie.201301259"},{"key":"ref4\/cit4","doi-asserted-by":"publisher","DOI":"10.1111\/j.1439-0418.1919.tb01424.x"},{"key":"ref5\/cit5a","first-page":"1434","volume":"43","author":"Quilico A.","year":"1961","journal-title":"Chim Ind."},{"key":"ref5\/cit5b","doi-asserted-by":"publisher","DOI":"10.1016\/S0040-4039(01)84020-X"},{"key":"ref5\/cit5c","first-page":"3","volume":"96","author":"Cardani C.","year":"1966","journal-title":"Gazz. Chim. Ital"},{"key":"ref5\/cit5d","doi-asserted-by":"publisher","DOI":"10.1016\/S0040-4039(00)75459-1"},{"key":"ref5\/cit5e","doi-asserted-by":"publisher","DOI":"10.1016\/S0040-4039(00)75458-X"},{"key":"ref6\/cit6a","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1007\/978-3-662-04042-3_2","volume-title":"The Role of Natural Products in Drug Discovery","author":"Narquizian R.","year":"2000"},{"key":"ref6\/cit6b","doi-asserted-by":"publisher","DOI":"10.1021\/np049612d"},{"key":"ref6\/cit6c","doi-asserted-by":"publisher","DOI":"10.1021\/ja3057002"},{"key":"ref6\/cit6d","doi-asserted-by":"publisher","DOI":"10.1021\/acschembio.7b01048"},{"key":"ref7\/cit7","doi-asserted-by":"publisher","DOI":"10.1021\/ol049503q"},{"key":"ref8\/cit8","doi-asserted-by":"publisher","DOI":"10.1021\/jm030207d"},{"key":"ref9\/cit9","doi-asserted-by":"publisher","DOI":"10.1021\/ja0537068"},{"key":"ref10\/cit10a","doi-asserted-by":"publisher","DOI":"10.1021\/ol071068n"},{"key":"ref10\/cit10b","doi-asserted-by":"publisher","DOI":"10.1021\/ol802466t"},{"key":"ref10\/cit10c","doi-asserted-by":"publisher","DOI":"10.1021\/ol901655e"},{"key":"ref10\/cit10d","doi-asserted-by":"publisher","DOI":"10.1055\/s-0029-1216926"},{"key":"ref10\/cit10e","doi-asserted-by":"publisher","DOI":"10.1021\/ol1000389"},{"key":"ref10\/cit10f","doi-asserted-by":"publisher","DOI":"10.1021\/ja207331m"},{"key":"ref10\/cit10g","doi-asserted-by":"publisher","DOI":"10.1021\/ol2024289"},{"key":"ref10\/cit10h","doi-asserted-by":"publisher","DOI":"10.1021\/ja3057612"},{"key":"ref10\/cit10i","doi-asserted-by":"publisher","DOI":"10.1021\/jo400260m"},{"key":"ref10\/cit10j","doi-asserted-by":"publisher","DOI":"10.1021\/acs.joc.5b02256"},{"key":"ref11\/cit11a","doi-asserted-by":"publisher","DOI":"10.1021\/ol063143k"},{"key":"ref11\/cit11b","doi-asserted-by":"crossref","first-page":"8300","DOI":"10.1002\/chem.201203149","volume":"19","author":"Bielitza M.","year":"2013","journal-title":"Chem.\u2013Eur. J."},{"key":"ref12\/cit12a","doi-asserted-by":"publisher","DOI":"10.1021\/ol0508375"},{"key":"ref12\/cit12b","doi-asserted-by":"publisher","DOI":"10.1021\/ol051396s"},{"key":"ref12\/cit12c","doi-asserted-by":"publisher","DOI":"10.1021\/ol0520267"},{"key":"ref12\/cit12d","doi-asserted-by":"publisher","DOI":"10.1016\/j.tetlet.2008.04.016"},{"key":"ref12\/cit12e","doi-asserted-by":"publisher","DOI":"10.1016\/j.tetlet.2008.07.170"},{"key":"ref12\/cit12f","doi-asserted-by":"publisher","DOI":"10.1021\/jo9009003"},{"key":"ref12\/cit12g","doi-asserted-by":"publisher","DOI":"10.3987\/COM-07-S(W)72"},{"key":"ref12\/cit12h","doi-asserted-by":"publisher","DOI":"10.1002\/ejoc.200900292"},{"key":"ref12\/cit12i","doi-asserted-by":"publisher","DOI":"10.1002\/ejoc.201101543"},{"key":"ref12\/cit12j","doi-asserted-by":"publisher","DOI":"10.1055\/s-0031-1290379"},{"key":"ref12\/cit12k","doi-asserted-by":"publisher","DOI":"10.1016\/j.tetlet.2013.05.153"},{"key":"ref12\/cit12l","doi-asserted-by":"publisher","DOI":"10.1021\/ol502264y"},{"key":"ref13\/cit13","doi-asserted-by":"publisher","DOI":"10.1021\/acs.orglett.9b01113"},{"key":"ref14\/cit14","doi-asserted-by":"publisher","DOI":"10.1021\/acs.orglett.5c00396"},{"key":"ref15\/cit15","doi-asserted-by":"publisher","DOI":"10.1021\/ol049008u"},{"key":"ref16\/cit16a","doi-asserted-by":"publisher","DOI":"10.1021\/jo100094d"},{"key":"ref16\/cit16b","doi-asserted-by":"publisher","DOI":"10.1021\/jo402262m"},{"key":"ref17\/cit17a","doi-asserted-by":"publisher","DOI":"10.1016\/j.tetlet.2005.07.075"},{"key":"ref17\/cit17b","doi-asserted-by":"publisher","DOI":"10.1016\/j.tetlet.2006.08.026"},{"key":"ref17\/cit17c","unstructured":"cSee SI for structural verification\nof compound\n                      19b\n                      ."},{"key":"ref18\/cit18a","doi-asserted-by":"publisher","DOI":"10.1021\/jo00417a036"},{"key":"ref18\/cit18b","doi-asserted-by":"publisher","DOI":"10.1016\/0040-4020(78)80197-5"},{"key":"ref19\/cit19","doi-asserted-by":"publisher","DOI":"10.1021\/jo020402k"},{"key":"ref20\/cit20","doi-asserted-by":"publisher","DOI":"10.1016\/S0040-4020(02)00657-9"},{"key":"ref21\/cit21","doi-asserted-by":"publisher","DOI":"10.1021\/ja038787r"},{"key":"ref22\/cit22","doi-asserted-by":"publisher","DOI":"10.1016\/j.tet.2007.11.092"},{"key":"ref23\/cit23","doi-asserted-by":"publisher","DOI":"10.1021\/ja972497r"},{"key":"ref24\/cit24a","doi-asserted-by":"publisher","DOI":"10.1016\/S0040-4039(00)85909-2"},{"key":"ref24\/cit24b","doi-asserted-by":"publisher","DOI":"10.1055\/s-0032-1317698"},{"key":"ref25\/cit25a","doi-asserted-by":"publisher","DOI":"10.1016\/S0040-4039(99)00956-9"},{"key":"ref25\/cit25b","doi-asserted-by":"publisher","DOI":"10.1016\/S0040-4020(00)00983-2"},{"key":"ref26\/cit26a","doi-asserted-by":"publisher","DOI":"10.1021\/ja00279a042"},{"key":"ref26\/cit26b","doi-asserted-by":"publisher","DOI":"10.1021\/ja994285v"},{"key":"ref27\/cit27a","doi-asserted-by":"publisher","DOI":"10.1021\/jo00142a002"},{"key":"ref27\/cit27b","doi-asserted-by":"publisher","DOI":"10.1016\/S0040-4039(00)79009-5"},{"key":"ref27\/cit27c","doi-asserted-by":"publisher","DOI":"10.1021\/jo00066a024"},{"key":"ref28\/cit28","doi-asserted-by":"publisher","DOI":"10.1016\/j.tetlet.2012.05.060"},{"key":"ref29\/cit29a","doi-asserted-by":"publisher","DOI":"10.1021\/ja036192q"},{"key":"ref29\/cit29b","doi-asserted-by":"publisher","DOI":"10.1021\/ja0484348"},{"key":"ref29\/cit29c","doi-asserted-by":"publisher","DOI":"10.1021\/ja064270e"},{"key":"ref30\/cit30a","doi-asserted-by":"publisher","DOI":"10.1021\/ja0620336"},{"key":"ref30\/cit30b","doi-asserted-by":"publisher","DOI":"10.1039\/b822944a"},{"key":"ref30\/cit30c","doi-asserted-by":"publisher","DOI":"10.1021\/jacs.6b00764"},{"key":"ref31\/cit31","doi-asserted-by":"publisher","DOI":"10.1021\/jo050075r"},{"key":"ref32\/cit32","doi-asserted-by":"publisher","DOI":"10.1021\/jo00365a034"},{"key":"ref33\/cit33a","doi-asserted-by":"publisher","DOI":"10.1021\/jo800727s"},{"key":"ref33\/cit33b","doi-asserted-by":"publisher","DOI":"10.1021\/ol200331u"},{"key":"ref34\/cit34a","doi-asserted-by":"publisher","DOI":"10.1021\/jo0009999"},{"key":"ref34\/cit34b","doi-asserted-by":"publisher","DOI":"10.1055\/s-0034-1380400"},{"key":"ref35\/cit35a","doi-asserted-by":"publisher","DOI":"10.1002\/anie.200353615"},{"key":"ref35\/cit35b","doi-asserted-by":"publisher","DOI":"10.1021\/ja042491j"},{"key":"ref36\/cit36a","doi-asserted-by":"publisher","DOI":"10.1021\/ar800036s"},{"key":"ref36\/cit36b","doi-asserted-by":"publisher","DOI":"10.1021\/ja068577p"},{"key":"ref37\/cit37","doi-asserted-by":"publisher","DOI":"10.1016\/j.tetlet.2009.04.069"},{"key":"ref38\/cit38","doi-asserted-by":"publisher","DOI":"10.1021\/jacs.8b07884"},{"key":"ref39\/cit39a","doi-asserted-by":"publisher","DOI":"10.1248\/cpb.42.1700"},{"key":"ref39\/cit39b","doi-asserted-by":"publisher","DOI":"10.1016\/0040-4039(95)02059-4"},{"key":"ref40\/cit40a","doi-asserted-by":"publisher","DOI":"10.1016\/S0040-4039(01)81697-X"},{"key":"ref40\/cit40b","doi-asserted-by":"publisher","DOI":"10.1002\/anie.200462207"}],"container-title":["The Journal of Organic Chemistry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/pubs.acs.org\/doi\/pdf\/10.1021\/acs.joc.5c02064","content-type":"application\/pdf","content-version":"vor","intended-application":"unspecified"},{"URL":"https:\/\/pubs.acs.org\/doi\/pdf\/10.1021\/acs.joc.5c02064","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,12,12]],"date-time":"2025-12-12T09:13:09Z","timestamp":1765530789000},"score":1,"resource":{"primary":{"URL":"https:\/\/pubs.acs.org\/doi\/10.1021\/acs.joc.5c02064"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,12,1]]},"references-count":90,"journal-issue":{"issue":"49","published-print":{"date-parts":[[2025,12,12]]}},"alternative-id":["10.1021\/acs.joc.5c02064"],"URL":"https:\/\/doi.org\/10.1021\/acs.joc.5c02064","relation":{},"ISSN":["0022-3263","1520-6904"],"issn-type":[{"value":"0022-3263","type":"print"},{"value":"1520-6904","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,12,1]]}}}