{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,17]],"date-time":"2026-01-17T00:51:26Z","timestamp":1768611086447,"version":"3.49.0"},"reference-count":45,"publisher":"American Chemical Society (ACS)","issue":"1","license":[{"start":{"date-parts":[[2025,12,26]],"date-time":"2025-12-26T00:00:00Z","timestamp":1766707200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001659","name":"Deutsche Forschungsgemeinschaft","doi-asserted-by":"publisher","award":["TRR 325444632635"],"award-info":[{"award-number":["TRR 325444632635"]}],"id":[{"id":"10.13039\/501100001659","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004350","name":"Studienstiftung des Deutschen Volkes","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004350","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100018992","name":"Fonds der Chemischen Industrie","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100018992","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100010663","name":"H2020 European Research Council","doi-asserted-by":"publisher","award":["803426"],"award-info":[{"award-number":["803426"]}],"id":[{"id":"10.13039\/100010663","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J. Org. Chem."],"published-print":{"date-parts":[[2026,1,9]]},"DOI":"10.1021\/acs.joc.5c02530","type":"journal-article","created":{"date-parts":[[2025,12,26]],"date-time":"2025-12-26T11:48:36Z","timestamp":1766749716000},"page":"793-797","source":"Crossref","is-referenced-by-count":0,"title":["Enantioconvergent Synthesis of Diarylmethane Drugs via Privileged Benzhydrol Intermediates"],"prefix":"10.1021","volume":"91","author":[{"ORCID":"https:\/\/orcid.org\/0009-0005-6245-4432","authenticated-orcid":true,"given":"Eduard","family":"Frank","sequence":"first","affiliation":[{"name":"Institute for Organic Chemistry","place":["Regensburg, Germany"]},{"name":"University of Regensburg","place":["Regensburg, Germany"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jana L.","family":"Fl\u00fcgel","sequence":"additional","affiliation":[{"name":"Institute for Organic Chemistry","place":["Regensburg, Germany"]},{"name":"University of Regensburg","place":["Regensburg, Germany"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ludwig","family":"d\u2019Heureuse","sequence":"additional","affiliation":[{"name":"Institute for Organic Chemistry","place":["Regensburg, Germany"]},{"name":"University of Regensburg","place":["Regensburg, Germany"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sophie","family":"Woick","sequence":"additional","affiliation":[{"name":"Institute for Organic Chemistry","place":["Regensburg, Germany"]},{"name":"University of Regensburg","place":["Regensburg, Germany"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4899-5919","authenticated-orcid":true,"given":"Alexander","family":"Breder","sequence":"additional","affiliation":[{"name":"Institute for Organic Chemistry","place":["Regensburg, Germany"]},{"name":"University of Regensburg","place":["Regensburg, Germany"]}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"316","published-online":{"date-parts":[[2025,12,26]]},"reference":[{"key":"ref1\/cit1","volume-title":"Drug Design: Medicinal Chemistry: A Series of Monographs","volume":"6","author":"Ari\u00ebns E. J.","year":"1975"},{"key":"ref2\/cit2","doi-asserted-by":"publisher","DOI":"10.1002\/asia.202000730"},{"key":"ref3\/cit3","doi-asserted-by":"publisher","DOI":"10.1177\/1049909109338937"},{"key":"ref4\/cit4","doi-asserted-by":"publisher","DOI":"10.1038\/clpt.1989.3"},{"key":"ref5\/cit5","doi-asserted-by":"publisher","DOI":"10.1016\/S0026-895X(24)26451-8"},{"key":"ref6\/cit6","doi-asserted-by":"publisher","DOI":"10.1016\/0143-4179(85)90041-1"},{"key":"ref7\/cit7","doi-asserted-by":"publisher","DOI":"10.1007\/s12024-012-9383-5"},{"key":"ref8\/cit8","doi-asserted-by":"publisher","DOI":"10.1097\/00000446-194710000-00004"},{"key":"ref9\/cit9","doi-asserted-by":"publisher","DOI":"10.1002\/ams2.351"},{"key":"ref10\/cit10","doi-asserted-by":"publisher","DOI":"10.1016\/S0165-6147(99)01437-6"},{"key":"ref11\/cit11","doi-asserted-by":"publisher","DOI":"10.1021\/np50059a043"},{"key":"ref12\/cit12","doi-asserted-by":"publisher","DOI":"10.1177\/030006059101900201"},{"key":"ref13\/cit13","doi-asserted-by":"publisher","DOI":"10.1016\/S0006-2952(03)00558-6"},{"key":"ref14\/cit14","doi-asserted-by":"publisher","DOI":"10.1034\/j.1398-9995.2001.00726.x"},{"key":"ref15\/cit15","doi-asserted-by":"publisher","DOI":"10.1046\/j.1472-8206.2001.00035.x"},{"key":"ref16\/cit16","doi-asserted-by":"publisher","DOI":"10.2165\/00023210-200317050-00004"},{"key":"ref17\/cit17","doi-asserted-by":"publisher","DOI":"10.1007\/s00213-002-1364-z"},{"key":"ref18\/cit18","doi-asserted-by":"publisher","DOI":"10.1016\/S0006-3223(01)01145-3"},{"key":"ref19\/cit19","doi-asserted-by":"publisher","DOI":"10.1016\/S0028-3908(03)00138-2"},{"key":"ref20\/cit20","doi-asserted-by":"publisher","DOI":"10.1002\/anie.202412193"},{"key":"ref21\/cit21","doi-asserted-by":"publisher","DOI":"10.1039\/b600091f"},{"key":"ref22\/cit22","doi-asserted-by":"publisher","DOI":"10.1007\/s11426-020-9910-2"},{"key":"ref23\/cit23","doi-asserted-by":"publisher","DOI":"10.1055\/s-2006-950315"},{"key":"ref24\/cit24","doi-asserted-by":"publisher","DOI":"10.1039\/D1OB00289A"},{"key":"ref25\/cit25","doi-asserted-by":"publisher","DOI":"10.1002\/anie.201813510"},{"key":"ref26\/cit26","doi-asserted-by":"publisher","DOI":"10.1021\/jacs.5b07827"},{"key":"ref27\/cit27","doi-asserted-by":"publisher","DOI":"10.1021\/jacs.2c07037"},{"key":"ref28\/cit28","doi-asserted-by":"publisher","DOI":"10.1021\/acs.joc.8b01276"},{"key":"ref29\/cit29","doi-asserted-by":"publisher","DOI":"10.1002\/anie.202416313"},{"key":"ref30\/cit30","doi-asserted-by":"publisher","DOI":"10.1021\/acs.orglett.0c00293"},{"key":"ref31\/cit31","doi-asserted-by":"publisher","DOI":"10.1002\/chem.201200379"},{"key":"ref32\/cit32","doi-asserted-by":"publisher","DOI":"10.1021\/jacs.5c06149"},{"key":"ref33\/cit33","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-023-37882-2"},{"key":"ref34\/cit34","doi-asserted-by":"publisher","DOI":"10.1016\/0040-4039(96)00964-1"},{"key":"ref35\/cit35","doi-asserted-by":"publisher","DOI":"10.1021\/jacs.9b07514"},{"key":"ref36\/cit36","doi-asserted-by":"publisher","DOI":"10.1021\/jacs.9b04551"},{"key":"ref37\/cit37","doi-asserted-by":"publisher","DOI":"10.1021\/jacs.4c09405"},{"key":"ref38\/cit38","doi-asserted-by":"publisher","DOI":"10.1021\/jo501122k"},{"key":"ref39\/cit39","doi-asserted-by":"publisher","DOI":"10.1002\/chem.200802488"},{"key":"ref40\/cit40","doi-asserted-by":"publisher","DOI":"10.1021\/jm00090a021"},{"key":"ref41\/cit41","doi-asserted-by":"publisher","unstructured":"Aliprandi, P.; Cima, L.; Carrara, M.; Therapeutic Use of Levocloperastine as an Antitussive Agent,\n                      Clin. Drug Invest.\n                      2002, 22, 209\u2013220, 10.2165\/00044011-200222040-00001.","DOI":"10.2165\/00044011-200222040-00001"},{"key":"ref42\/cit42","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejmech.2025.117371"},{"key":"ref43\/cit43","doi-asserted-by":"publisher","DOI":"10.1016\/j.jmir.2024.101469"},{"key":"ref44\/cit44","doi-asserted-by":"publisher","DOI":"10.3390\/ph14020169"},{"key":"ref45\/cit45","doi-asserted-by":"publisher","DOI":"10.1126\/scitranslmed.3010286"}],"container-title":["The Journal of Organic Chemistry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/pubs.acs.org\/doi\/pdf\/10.1021\/acs.joc.5c02530","content-type":"application\/pdf","content-version":"vor","intended-application":"unspecified"},{"URL":"https:\/\/pubs.acs.org\/doi\/pdf\/10.1021\/acs.joc.5c02530","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,1,16]],"date-time":"2026-01-16T13:19:04Z","timestamp":1768569544000},"score":1,"resource":{"primary":{"URL":"https:\/\/pubs.acs.org\/doi\/10.1021\/acs.joc.5c02530"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,12,26]]},"references-count":45,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2026,1,9]]}},"alternative-id":["10.1021\/acs.joc.5c02530"],"URL":"https:\/\/doi.org\/10.1021\/acs.joc.5c02530","relation":{},"ISSN":["0022-3263","1520-6904"],"issn-type":[{"value":"0022-3263","type":"print"},{"value":"1520-6904","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,12,26]]}}}