{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,17]],"date-time":"2026-02-17T03:07:13Z","timestamp":1771297633941,"version":"3.50.1"},"reference-count":33,"publisher":"American Chemical Society (ACS)","issue":"1","license":[{"start":{"date-parts":[[2025,12,19]],"date-time":"2025-12-19T00:00:00Z","timestamp":1766102400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2025,12,19]],"date-time":"2025-12-19T00:00:00Z","timestamp":1766102400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2025,12,19]],"date-time":"2025-12-19T00:00:00Z","timestamp":1766102400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-045"}],"funder":[{"DOI":"10.13039\/100009619","name":"Japan Agency for Medical Research and Development","doi-asserted-by":"publisher","award":["25ama121032"],"award-info":[{"award-number":["25ama121032"]}],"id":[{"id":"10.13039\/100009619","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001691","name":"Japan Society for the Promotion of Science","doi-asserted-by":"publisher","award":["15H02495"],"award-info":[{"award-number":["15H02495"]}],"id":[{"id":"10.13039\/501100001691","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001691","name":"Japan Society for the Promotion of Science","doi-asserted-by":"publisher","award":["17K08360"],"award-info":[{"award-number":["17K08360"]}],"id":[{"id":"10.13039\/501100001691","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001691","name":"Japan Society for the Promotion of Science","doi-asserted-by":"publisher","award":["19H01014"],"award-info":[{"award-number":["19H01014"]}],"id":[{"id":"10.13039\/501100001691","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001691","name":"Japan Society for the Promotion of Science","doi-asserted-by":"publisher","award":["20K06941"],"award-info":[{"award-number":["20K06941"]}],"id":[{"id":"10.13039\/501100001691","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002241","name":"Japan Science and Technology Agency","doi-asserted-by":"publisher","award":["JPMJSP2113"],"award-info":[{"award-number":["JPMJSP2113"]}],"id":[{"id":"10.13039\/501100002241","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J. Org. Chem."],"published-print":{"date-parts":[[2026,1,9]]},"DOI":"10.1021\/acs.joc.5c02534","type":"journal-article","created":{"date-parts":[[2025,12,20]],"date-time":"2025-12-20T02:34:26Z","timestamp":1766198066000},"page":"466-476","source":"Crossref","is-referenced-by-count":1,"title":["Design and Synthesis of Cyclopropane Congeners of Resolvin E2 with Azidopropoxy Chain toward a Chemical Tool for Probing the Anti-inflammatory Activity"],"prefix":"10.1021","volume":"91","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1636-4469","authenticated-orcid":true,"given":"Hayato","family":"Fukuda","sequence":"first","affiliation":[{"name":"Graduate School of Biomedical Sciences","place":["Nagasaki, Japan"]},{"name":"Nagasaki University","place":["Nagasaki, Japan"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kotaro","family":"Matsubara","sequence":"additional","affiliation":[{"name":"Faculty of Pharmaceutical Sciences","place":["Sapporo, Japan"]},{"name":"Hokkaido University","place":["Sapporo, Japan"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ayaka","family":"Hamaguchi","sequence":"additional","affiliation":[{"name":"Department of Pharmacology for Life Sciences, Graduate School of Pharmaceutical Sciences & Graduate School of Biomedical Sciences","place":["Tokushima, Japan"]},{"name":"Tokushima University","place":["Tokushima, Japan"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hina","family":"Nishikoori","sequence":"additional","affiliation":[{"name":"Graduate School of Biomedical Sciences","place":["Nagasaki, Japan"]},{"name":"Nagasaki University","place":["Nagasaki, Japan"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mayu","family":"Shinohara","sequence":"additional","affiliation":[{"name":"Department of Pharmacology for Life Sciences, Graduate School of Pharmaceutical Sciences & Graduate School of Biomedical Sciences","place":["Tokushima, Japan"]},{"name":"Tokushima University","place":["Tokushima, Japan"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jun","family":"Takouda","sequence":"additional","affiliation":[{"name":"Graduate School of Biomedical Sciences","place":["Nagasaki, Japan"]},{"name":"Nagasaki University","place":["Nagasaki, Japan"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kohsuke","family":"Takeda","sequence":"additional","affiliation":[{"name":"Graduate School of Biomedical Sciences","place":["Nagasaki, Japan"]},{"name":"Nagasaki University","place":["Nagasaki, Japan"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Keijo","family":"Fukushima","sequence":"additional","affiliation":[{"name":"Department of Pharmacology for Life Sciences, Graduate School of Pharmaceutical Sciences & Graduate School of Biomedical Sciences","place":["Tokushima, Japan"]},{"name":"Tokushima University","place":["Tokushima, Japan"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Keita","family":"Komine","sequence":"additional","affiliation":[{"name":"Graduate School of Biomedical Sciences","place":["Nagasaki, Japan"]},{"name":"Nagasaki University","place":["Nagasaki, Japan"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6848-1715","authenticated-orcid":true,"given":"Koichi","family":"Fujiwara","sequence":"additional","affiliation":[{"name":"Faculty of Pharmaceutical Sciences","place":["Sapporo, Japan"]},{"name":"Hokkaido University","place":["Sapporo, Japan"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7209-5713","authenticated-orcid":true,"given":"Mizuki","family":"Watanabe","sequence":"additional","affiliation":[{"name":"Faculty of Pharmaceutical Sciences","place":["Sapporo, Japan"]},{"name":"Hokkaido University","place":["Sapporo, Japan"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3346-3354","authenticated-orcid":true,"given":"Jun","family":"Ishihara","sequence":"additional","affiliation":[{"name":"Graduate School of Biomedical Sciences","place":["Nagasaki, Japan"]},{"name":"Nagasaki University","place":["Nagasaki, Japan"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hiromichi","family":"Fujino","sequence":"additional","affiliation":[{"name":"Department of Pharmacology for Life Sciences, Graduate School of Pharmaceutical Sciences & Graduate School of Biomedical Sciences","place":["Tokushima, Japan"]},{"name":"Tokushima University","place":["Tokushima, Japan"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7850-8064","authenticated-orcid":true,"given":"Satoshi","family":"Shuto","sequence":"additional","affiliation":[{"name":"Faculty of Pharmaceutical Sciences","place":["Sapporo, Japan"]},{"name":"Hokkaido University","place":["Sapporo, Japan"]}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"316","published-online":{"date-parts":[[2025,12,19]]},"reference":[{"key":"ref1\/cit1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI31537"},{"key":"ref2\/cit2","doi-asserted-by":"publisher","DOI":"10.1038\/nri.2017.49"},{"key":"ref3\/cit3","doi-asserted-by":"publisher","DOI":"10.1155\/2012\/693083"},{"key":"ref4\/cit4","doi-asserted-by":"publisher","DOI":"10.1172\/JCI26498"},{"key":"ref5\/cit5","doi-asserted-by":"publisher","DOI":"10.1038\/s41580-023-00680-1"},{"key":"ref6\/cit6","doi-asserted-by":"publisher","DOI":"10.1016\/j.plefa.2005.05.002"},{"key":"ref7\/cit7","doi-asserted-by":"publisher","DOI":"10.2174\/1568026611109060629"},{"key":"ref8\/cit8","doi-asserted-by":"publisher","DOI":"10.1021\/cr100396c"},{"key":"ref9\/cit9","doi-asserted-by":"publisher","DOI":"10.1084\/jem.192.8.1197"},{"key":"ref10\/cit10","doi-asserted-by":"publisher","DOI":"10.1016\/j.chembiol.2006.09.011"},{"key":"ref11\/cit11","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2020.631319"},{"key":"ref12\/cit12","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M112.340612"},{"key":"ref13\/cit13","doi-asserted-by":"publisher","DOI":"10.1016\/j.smim.2022.101597"},{"key":"ref14\/cit14","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20042031"},{"key":"ref15\/cit15","doi-asserted-by":"publisher","DOI":"10.1021\/acsmedchemlett.0c00639"},{"key":"ref16\/cit16","doi-asserted-by":"publisher","DOI":"10.1021\/acs.orglett.6b02612"},{"key":"ref17\/cit17","doi-asserted-by":"publisher","DOI":"10.1021\/acsmedchemlett.9b00596"},{"key":"ref18\/cit18","doi-asserted-by":"publisher","DOI":"10.1021\/acs.joc.2c01110"},{"key":"ref19\/cit19","doi-asserted-by":"publisher","DOI":"10.1021\/acs.joc.0c01701"},{"key":"ref20\/cit20","doi-asserted-by":"publisher","DOI":"10.1002\/1873-3468.13215"},{"key":"ref21\/cit21","doi-asserted-by":"publisher","DOI":"10.1096\/fj.201900283R"},{"key":"ref22\/cit22","doi-asserted-by":"publisher","DOI":"10.1096\/fj.202100053r"},{"key":"ref23\/cit23","doi-asserted-by":"publisher","DOI":"10.1016\/j.prostaglandins.2023.106759"},{"key":"ref24\/cit24","doi-asserted-by":"publisher","DOI":"10.1007\/s13311-022-01337-1"},{"key":"ref25\/cit25","doi-asserted-by":"publisher","DOI":"10.1039\/C9OB01276A"},{"key":"ref26\/cit26","doi-asserted-by":"publisher","DOI":"10.1002\/cbic.202400923"},{"key":"ref27\/cit27","doi-asserted-by":"publisher","DOI":"10.1002\/1521-3773(20020715)41:14<2596::AID-ANIE2596>3.0.CO;2-4"},{"key":"ref28\/cit28","doi-asserted-by":"publisher","DOI":"10.1002\/ejoc.200500483"},{"key":"ref29\/cit29","doi-asserted-by":"publisher","DOI":"10.1002\/1521-3765(20010803)7:15<3363::aid-chem3363>3.0.co;2-y"},{"key":"ref30\/cit30","doi-asserted-by":"publisher","DOI":"10.1016\/0040-4020(96)00316-X"},{"key":"ref31\/cit31","doi-asserted-by":"publisher","DOI":"10.1021\/ol702982x"},{"key":"ref32\/cit32","doi-asserted-by":"publisher","DOI":"10.1002\/hlca.19870700415"},{"key":"ref33\/cit33","doi-asserted-by":"publisher","DOI":"10.1002\/anie.201310060"}],"container-title":["The Journal of Organic Chemistry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/pubs.acs.org\/doi\/pdf\/10.1021\/acs.joc.5c02534","content-type":"application\/pdf","content-version":"vor","intended-application":"unspecified"},{"URL":"https:\/\/pubs.acs.org\/doi\/pdf\/10.1021\/acs.joc.5c02534","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,1,16]],"date-time":"2026-01-16T13:20:50Z","timestamp":1768569650000},"score":1,"resource":{"primary":{"URL":"https:\/\/pubs.acs.org\/doi\/10.1021\/acs.joc.5c02534"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,12,19]]},"references-count":33,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2026,1,9]]}},"alternative-id":["10.1021\/acs.joc.5c02534"],"URL":"https:\/\/doi.org\/10.1021\/acs.joc.5c02534","relation":{},"ISSN":["0022-3263","1520-6904"],"issn-type":[{"value":"0022-3263","type":"print"},{"value":"1520-6904","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,12,19]]}}}