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We report here a general three-component Sila-Strecker reaction that utilizes an air- and moisture-stable Cu(II) salt catalyst, a silylation reagent, and ubiquitous starting materials, including a variety of amines (aryl amines, sulfamides, and sulfinamides) and carbonyl compounds (aldehydes and ketones). Diverse synthetically useful and pharmaceutically relevant \u03b1-aminosilanes are synthesized in moderate to excellent yields. Preliminary mechanistic investigation indicated an imine intermediate, which formed with the promotion of Ti(OEt)4. Compared with previous attempts, the established method offers a step-economic, operationally simple, and broadly tolerant approach that proceeds to \u03b1-aminosilane synthesis under mild conditions. Moreover, this reaction has been applied to the late-stage functionalization of a variety of bioactive natural products.<\/jats:p>","DOI":"10.1021\/acs.joc.6c00375","type":"journal-article","created":{"date-parts":[[2026,7,17]],"date-time":"2026-07-17T12:36:44Z","timestamp":1784291804000},"page":"10343-10350","source":"Crossref","is-referenced-by-count":0,"title":["Cu(II)-Catalyzed\nThree-Component Sila-Strecker Reaction"],"prefix":"10.1021","volume":"91","author":[{"given":"Yu","family":"Niu","sequence":"first","affiliation":[{"name":"Guangzhou University of Chinese Medicine , , ,","place":["Guangzhou, China, 510006"]},{"name":"Chinese Medicine Guangdong Laboratory , ,","place":["Hengqin, China, 519031"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaocui","family":"Liu","sequence":"additional","affiliation":[{"name":"Chinese Medicine Guangdong Laboratory , ,","place":["Hengqin, China, 519031"]},{"name":"The Second Affiliated Hospital of Guangzhou University of Chinese Medicine (Guangdong Provincial Hospital of Chinese Medicine) , , ,","place":["Guangzhou, China, 510006"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Meiling","family":"Li","sequence":"additional","affiliation":[{"name":"Guangzhou University of Chinese Medicine , , ,","place":["Guangzhou, China, 510006"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6265-2325","authenticated-orcid":true,"given":"Kun","family":"Liu","sequence":"additional","affiliation":[{"name":"Guangzhou University of Chinese Medicine , , ,","place":["Guangzhou, China, 510006"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6112-5040","authenticated-orcid":true,"given":"Guochao","family":"Liao","sequence":"additional","affiliation":[{"name":"Guangzhou University of Chinese Medicine , , ,","place":["Guangzhou, China, 510006"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6986-9677","authenticated-orcid":true,"given":"Zhongqiu","family":"Liu","sequence":"additional","affiliation":[{"name":"Guangzhou University of Chinese Medicine , , ,","place":["Guangzhou, China, 510006"]},{"name":"Chinese Medicine Guangdong Laboratory , ,","place":["Hengqin, China, 519031"]},{"name":"The Second Affiliated Hospital of Guangzhou University of Chinese Medicine (Guangdong Provincial Hospital of Chinese Medicine) , , ,","place":["Guangzhou, China, 510006"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8839-685X","authenticated-orcid":true,"given":"Xiang","family":"Luo","sequence":"additional","affiliation":[{"name":"Guangzhou University of Chinese Medicine , , ,","place":["Guangzhou, China, 510006"]},{"name":"Chinese Medicine Guangdong Laboratory , ,","place":["Hengqin, China, 519031"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7736-8493","authenticated-orcid":true,"given":"Wenbo","family":"Ming","sequence":"additional","affiliation":[{"name":"Guangzhou University of Chinese Medicine , , ,","place":["Guangzhou, China, 510006"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"316","published-online":{"date-parts":[[2026,7,17]]},"reference":[{"key":"2026090713232672800_cit1","doi-asserted-by":"crossref","DOI":"10.1002\/9783527814787","volume-title":"Organosilicon Chemistry:\nNovel Approaches and Reactions","author":"Hiyama","year":"2019"},{"key":"2026090713232672800_cit2","doi-asserted-by":"publisher","first-page":"1002","DOI":"10.1039\/b816769a","article-title":"Synthesis and applications\nof silicon-containing \u03b1-amino acids","volume":"38","author":"Mortensen","year":"2009","journal-title":"Chem.\nSoc. 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