{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,22]],"date-time":"2026-10-22T18:24:27Z","timestamp":1792693467411,"version":"4.5.0"},"reference-count":24,"publisher":"American Chemical Society (ACS)","issue":"35","license":[{"start":{"date-parts":[[2026,8,24]],"date-time":"2026-08-24T00:00:00Z","timestamp":1787529600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2026,8,24]],"date-time":"2026-08-24T00:00:00Z","timestamp":1787529600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2026,8,24]],"date-time":"2026-08-24T00:00:00Z","timestamp":1787529600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-045"}],"funder":[{"DOI":"10.13039\/501100003725","name":"National Research Foundation of Korea","doi-asserted-by":"publisher","award":["RS-2023-00235550"],"award-info":[{"award-number":["RS-2023-00235550"]}],"id":[{"id":"10.13039\/501100003725","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026,9,4]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>DNA-encoded library (DEL) synthesis necessitates robust on-DNA chemical transformations that remain dependable throughout multistep library construction, especially for elongated DNA constructs. This study assessed the efficiency of commonly used on-DNA nitro reduction reactions under conditions relevant to practical DEL synthesis to evaluate the impact of DNA tag elongation. Although iron(II)-, diboron-, palladium(II)-, and dithionite-mediated reductions showed high efficiency for short DNA constructs, their performances varied significantly with DNA tag elongation. The generality of these reduction conditions was further explored across a diverse set of nitro-containing substrates, and their chemoselectivities toward additional functional groups were assessed to reflect realistic DEL design considerations. These findings underscore the importance of evaluating on-DNA chemistry beyond minimal tag systems and offer practical guidance for selecting suitable nitro reduction conditions for reliable DEL construction.<\/jats:p>","DOI":"10.1021\/acs.joc.6c00675","type":"journal-article","created":{"date-parts":[[2026,8,31]],"date-time":"2026-08-31T16:21:08Z","timestamp":1788193268000},"page":"11916-11922","source":"Crossref","is-referenced-by-count":2,"title":["Systematic Evaluation\nof On-DNA Nitro Reduction Reactions\nin Short and Elongated DNA Tags for DNA-Encoded Library Construction"],"prefix":"10.1021","volume":"91","author":[{"given":"Yeongjoo","family":"Suh","sequence":"first","affiliation":[{"name":"Korea Research Institute of Chemical Technology , , ,","place":["Daejeon, Republic of Korea, 34114"]},{"name":"University of Science & Technology , , ,","place":["Daejeon, Republic of Korea, 34113"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kyung-Jin","family":"Cho","sequence":"additional","affiliation":[{"name":"Korea Research Institute of Chemical Technology , , ,","place":["Daejeon, Republic of Korea, 34114"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6568-0658","authenticated-orcid":true,"given":"Hyun Jin","family":"Kim","sequence":"additional","affiliation":[{"name":"Korea Research Institute of Chemical Technology , , ,","place":["Daejeon, Republic of Korea, 34114"]},{"name":"University of Science & Technology , , ,","place":["Daejeon, Republic of Korea, 34113"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5153-5118","authenticated-orcid":true,"given":"Hongjun","family":"Jeon","sequence":"additional","affiliation":[{"name":"Korea Research Institute of Chemical Technology , , ,","place":["Daejeon, Republic of Korea, 34114"]},{"name":"University of Science & Technology , , ,","place":["Daejeon, Republic of Korea, 34113"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"316","published-online":{"date-parts":[[2026,8,24]]},"reference":[{"issue":"59","key":"2026090408100568200_cit1","doi-asserted-by":"publisher","first-page":"10952","DOI":"10.1039\/D5CC02904J","article-title":"Recent Advances\nin DNA-Encoded Libraries","volume":"61","author":"Gao","year":"2025","journal-title":"Chem. 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