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This photoinduced protocol was conducted under an aerobic-aqueous medium using Eosin Y as a photosensitizer. A diverse range of ynone derivatives were prepared from propargyl alcohol in moderate to excellent yield. Furthermore, the successful gram-scale experiment of this method also indicates its flexibility and applicability for industrial applications. Steric mapping of the series 2a\u20132q, exemplified by 2j, revealed an optimized buried volume and three-dimensional bulk distribution that closely mimics the reference PKC inhibitor while surpassing the less efficient steric profiles of the MSY and VCAM1 analogues. In addition, an exit vector analysis was carried out to get a clearer insight into the substituent orientation and spatial vector divergence.<\/jats:p>","DOI":"10.1021\/acs.joc.6c00757","type":"journal-article","created":{"date-parts":[[2026,8,7]],"date-time":"2026-08-07T04:01:49Z","timestamp":1786075309000},"page":"11670-11677","source":"Crossref","is-referenced-by-count":0,"title":["A Greener Approach toward\nYnones via Visible-Light-Induced\nOxidation of Propargyl Alcohols under Aqueous-Aerobic Conditions"],"prefix":"10.1021","volume":"91","author":[{"given":"Biman","family":"Bera","sequence":"first","affiliation":[{"name":"Indian Institute of Engineering Science and Technology (IIEST) , , Shibpur, PO- Botanic Garden , , ,","place":["Howrah, West Bengal, India, 711 103"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Arabinda","family":"Halder","sequence":"additional","affiliation":[{"name":"Indian Institute of Engineering Science and Technology (IIEST) , , Shibpur, PO- Botanic Garden , , ,","place":["Howrah, West Bengal, India, 711 103"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pradeep","family":"Kumar","sequence":"additional","affiliation":[{"name":"CSIR\u2212Central Institute of Medicinal and Aromatic Plants , , , ,","place":["Lucknow, Uttar Pradesh, India, 226015"]},{"name":"Academy of Scientific and Innovative Research (AcSIR) , , ,","place":["Ghaziabad, Uttar Pradesh, India, 201002"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9594-2209","authenticated-orcid":true,"given":"Prema G.","family":"Vasudev","sequence":"additional","affiliation":[{"name":"CSIR\u2212Central Institute of Medicinal and Aromatic Plants , , , ,","place":["Lucknow, Uttar Pradesh, India, 226015"]},{"name":"Academy of Scientific and Innovative Research (AcSIR) , , ,","place":["Ghaziabad, Uttar Pradesh, India, 201002"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Musa A.","family":"Said","sequence":"additional","affiliation":[{"name":"Islamic University of Madinah , , ,","place":["Madinah, Saudi Arabia, 42351"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4382-6841","authenticated-orcid":true,"given":"Mrinal K.","family":"Bera","sequence":"additional","affiliation":[{"name":"Indian Institute of Engineering Science and Technology (IIEST) , , Shibpur, PO- Botanic Garden , , ,","place":["Howrah, West Bengal, India, 711 103"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"316","published-online":{"date-parts":[[2026,8,6]]},"reference":[{"issue":"22","key":"2026090200072883100_cit1a","doi-asserted-by":"publisher","first-page":"5273","DOI":"10.1039\/D5OB00524H","article-title":"Total synthesis of\nnatural products via conjugated ynone intermediates:\na new millennium update","volume":"23","author":"Bhagat","year":"2025","journal-title":"Org. 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