{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,9]],"date-time":"2026-10-09T03:01:35Z","timestamp":1791514895078,"version":"4.3.4"},"reference-count":52,"publisher":"American Chemical Society (ACS)","issue":"31","license":[{"start":{"date-parts":[[2026,7,28]],"date-time":"2026-07-28T00:00:00Z","timestamp":1785196800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2026,7,28]],"date-time":"2026-07-28T00:00:00Z","timestamp":1785196800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2026,7,28]],"date-time":"2026-07-28T00:00:00Z","timestamp":1785196800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-045"}],"funder":[{"DOI":"10.13039\/501100001843","name":"Science and Engineering Research Board","doi-asserted-by":"publisher","award":["SUR\/2022\/002945"],"award-info":[{"award-number":["SUR\/2022\/002945"]}],"id":[{"id":"10.13039\/501100001843","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026,8,7]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>We report a silver(I)-catalyzed three-component A3-coupling strategy for the synthesis of 2-chloro-(phenylvinyl)imidazo[1,2-a]pyridines from 2-aminopyridines, terminal alkynes, and \u03b2-chlorovinyl aldehydes. The transformation proceeds under mild conditions with high regioselectivity, broad substrate scope, and excellent functional-group tolerance. Notably, retention of the vinylic C\u2013Cl bond in the products provides access to structurally important chlorovinyl-substituted imidazo[1,2-a]pyridines. The retained chlorovinyl motif may offer potential value for further diversification and for the development of medicinal chemistry-oriented scaffolds and pharmacophores. The protocol is operationally simple and scalable, as demonstrated by gram-scale synthesis. Its synthetic utility is further highlighted through the late-stage functionalization of complex molecules, including Naproxen and Gemfibrozil, as well as the synthesis of amino acid-derived 2-chloro-(phenylvinyl)imidazo[1,2-a]pyridines. These results underscore the versatility of the protocol and its potential applications in medicinal chemistry, molecular diversification, and drug discovery.<\/jats:p>","DOI":"10.1021\/acs.joc.6c00807","type":"journal-article","created":{"date-parts":[[2026,8,4]],"date-time":"2026-08-04T13:12:09Z","timestamp":1785849129000},"page":"10664-10671","source":"Crossref","is-referenced-by-count":1,"title":["Silver(I)-Catalyzed\nA3-Coupling\nfor the Regioselective Synthesis of 2-Chloro-(Phenylvinyl)imidazo[1,2-\n                    <i>a<\/i>\n                    ]pyridines and Late-Stage Drug Functionalization"],"prefix":"10.1021","volume":"91","author":[{"given":"Abhishek","family":"Saini","sequence":"first","affiliation":[{"name":"Baba Farid College , , ,","place":["Bathinda, India, 151002"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rishu","family":"Mehta","sequence":"additional","affiliation":[{"name":"Central University of Punjab , , ,","place":["Bathinda, India, 151001"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kamaldeep","family":"Kaur","sequence":"additional","affiliation":[{"name":"Central University of Punjab , , ,","place":["Bathinda, India, 151001"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Virender","family":"Singh","sequence":"additional","affiliation":[{"name":"Central University of Punjab , , ,","place":["Bathinda, India, 151001"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Manpreet","family":"Singh","sequence":"additional","affiliation":[{"name":"Baba Farid College , , ,","place":["Bathinda, India, 151002"]},{"name":"Baba Farid College of Engineering and Technology , ,","place":["Bathinda, India, 151002"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"316","published-online":{"date-parts":[[2026,7,28]]},"reference":[{"key":"2026080708074684400_cit1a","doi-asserted-by":"publisher","first-page":"347","DOI":"10.1016\/j.cbpa.2010.02.018","article-title":"Privileged\nscaffolds for library design and drug discovery","volume":"14","author":"Welsch","year":"2010","journal-title":"Curr. 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