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This transformation proceeds without any metal catalysts and enables one-step pyran ring construction under mild conditions with high atom and step economy. Notably, by simply modulating the substrate structure or reaction conditions, two distinct skeletons\u2500trifluoromethyl-substituted 2H-pyrans or fluorine-substituted 4H-pyrans\u2500can be selectively obtained. This divergent synthesis strategy allows rapid access to a diverse library of pyran derivatives from identical starting materials, greatly enhancing synthetic efficiency and flexibility. Furthermore, the reaction features broad substrate scope, operational simplicity, and environmental friendliness. Thus, it provides a highly valuable strategy for the synthesis of bioactive molecules. The simplicity and green nature of this method render it promising for broad application in medicinal chemistry and related fields.<\/jats:p>","DOI":"10.1021\/acs.joc.6c00886","type":"journal-article","created":{"date-parts":[[2026,7,21]],"date-time":"2026-07-21T03:25:19Z","timestamp":1784604319000},"page":"10425-10436","source":"Crossref","is-referenced-by-count":0,"title":["Emerging Strategies\nfor Controlled Defluorinative\nCyclization: One-Pot Synthesis of Fluoro-Substituted 4\n                    <i>H<\/i>\n                    -Pyrans or Trifluoromethyl-Substituted 2\n                    <i>H<\/i>\n                    -Pyrans"],"prefix":"10.1021","volume":"91","author":[{"given":"Zekun","family":"Li","sequence":"first","affiliation":[{"name":"Guangdong Pharmaceutical University , , ,","place":["Zhongshan, China, 528458"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zilin","family":"Fan","sequence":"additional","affiliation":[{"name":"Guangdong Pharmaceutical University , , ,","place":["Zhongshan, China, 528458"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bin","family":"Wang","sequence":"additional","affiliation":[{"name":"Guizhou University , , ,","place":["Guiyang, China, 550025"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wenchong","family":"Wu","sequence":"additional","affiliation":[{"name":"Guangdong Pharmaceutical University , , ,","place":["Zhongshan, China, 528458"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Haokai","family":"Liao","sequence":"additional","affiliation":[{"name":"Guangdong Pharmaceutical University , , ,","place":["Zhongshan, China, 528458"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8825-0175","authenticated-orcid":true,"given":"Hua","family":"Cao","sequence":"additional","affiliation":[{"name":"Guangdong Pharmaceutical University , , ,","place":["Zhongshan, China, 528458"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"316","published-online":{"date-parts":[[2026,7,20]]},"reference":[{"key":"2026073108243947100_cit1a","doi-asserted-by":"publisher","first-page":"753","DOI":"10.1016\/j.ejmech.2018.09.041","article-title":"Design,\nSynthesis and Biological Evaluation of 2-Substituted 3-Hydroxy-6-methyl-4H-pyran-4-one Derivatives as Pseudomonas aeruginosa Biofilm\nInhibitors","volume":"158","author":"Li","year":"2018","journal-title":"Eur. 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