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Our method is operationally simple and affords the deprotected amines as the corresponding disulfonate salts in up to quantitative yields. The reaction is mild and enables efficient deprotection in the presence of other sensitive functional groups. These salts are easily isolable via filtration from the reaction mixture and can be used as is in commonly employed reactions (i.e., reductive amination, amide coupling, Buchwald\u2013Hartwig coupling). Additionally, we disclose the ammonium disulfonate salt as a bench-stable, non-hygroscopic source of ammonia.<\/jats:p>","DOI":"10.1021\/acs.joc.6c00963","type":"journal-article","created":{"date-parts":[[2026,8,12]],"date-time":"2026-08-12T13:03:05Z","timestamp":1786539785000},"page":"11698-11703","source":"Crossref","is-referenced-by-count":1,"title":["A Mild Boc Deprotection Using Armstrong\u2019s Acid"],"prefix":"10.1021","volume":"91","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4852-3439","authenticated-orcid":true,"given":"Bijan","family":"Mirabi","sequence":"first","affiliation":[{"name":"AbbVie Inc. , , , ,","place":["North Chicago, Illinois, United States, 60044"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Byung Joo","family":"Lee","sequence":"additional","affiliation":[{"name":"AbbVie Inc. , , , ,","place":["North Chicago, Illinois, United States, 60044"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Annie R.","family":"Hooper","sequence":"additional","affiliation":[{"name":"AbbVie Inc. , , , ,","place":["North Chicago, Illinois, United States, 60044"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"316","published-online":{"date-parts":[[2026,8,12]]},"reference":[{"key":"2026090200062800100_cit1","doi-asserted-by":"crossref","DOI":"10.1002\/0470053488","volume-title":"Greene\u2019s Protective\nGroups in Organic Synthesis","author":"Wuts","year":"2006","edition":"4th"},{"key":"2026090200062800100_cit2","doi-asserted-by":"publisher","first-page":"193","DOI":"10.1038\/nchem.216","article-title":"Protecting-Group Free Synthesis as\nan Opportunity for\nInvention","volume":"1","author":"Young","year":"2009","journal-title":"Nat. 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