{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,4]],"date-time":"2026-09-04T13:12:50Z","timestamp":1788527570274,"version":"build-2803163510"},"reference-count":23,"publisher":"American Chemical Society (ACS)","issue":"35","license":[{"start":{"date-parts":[[2026,8,26]],"date-time":"2026-08-26T00:00:00Z","timestamp":1787702400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2026,8,26]],"date-time":"2026-08-26T00:00:00Z","timestamp":1787702400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2026,8,26]],"date-time":"2026-08-26T00:00:00Z","timestamp":1787702400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-045"}],"funder":[{"DOI":"10.13039\/501100019065","name":"Tianjin Municipal Science and Technology Program","doi-asserted-by":"publisher","award":["25ZYCGSN01200"],"award-info":[{"award-number":["25ZYCGSN01200"]}],"id":[{"id":"10.13039\/501100019065","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/na","name":"PoenDeute Pharma (Tianjin) Co., Ltd.","doi-asserted-by":"publisher","award":["2023430HJ0277"],"award-info":[{"award-number":["2023430HJ0277"]}],"id":[{"id":"10.13039\/na","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026,9,4]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Herein, we report a convenient and efficient method for the reductive multideuteration of 2-vinylquinolines and 2-methylquinolines utilizing a Mg\/CH3OD system. By employing readily available CH3OD as a deuterium source, this method achieves 3\u20135 deuterium atoms incorporation into the target structures. Moreover, the Mg\/CH3OH system smoothly reduced quinoline substrates to the corresponding tetrahydroquinoline products. This protocol offers a practical and mild approach for high-level deuterium incorporation using inexpensive reagents while avoiding complex catalysts and harsh conditions. This work opens up a new avenue for the use of Mg\/CH3OD in deuterium labeling.<\/jats:p>","DOI":"10.1021\/acs.joc.6c01045","type":"journal-article","created":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T07:27:47Z","timestamp":1788247667000},"page":"11952-11957","source":"Crossref","is-referenced-by-count":0,"title":["Mg\/CH3OD-Mediated\nMultideuteration of 2-Vinylquinolines\nand 2-Methylquinolines"],"prefix":"10.1021","volume":"91","author":[{"ORCID":"https:\/\/orcid.org\/0009-0000-8889-4536","authenticated-orcid":true,"given":"Peng-Hui","family":"Ma","sequence":"first","affiliation":[{"name":"Nankai University , , ,","place":["Tianjin, P. R. China, 300353"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peng","family":"Zhou","sequence":"additional","affiliation":[{"name":"Nankai University , , ,","place":["Tianjin, P. R. China, 300353"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhong-Xu","family":"Pei","sequence":"additional","affiliation":[{"name":"Nankai University , , ,","place":["Tianjin, P. R. China, 300353"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ke-Han","family":"Chen","sequence":"additional","affiliation":[{"name":"Nankai University , , ,","place":["Tianjin, P. R. China, 300353"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3674-8980","authenticated-orcid":true,"given":"Bin","family":"Wang","sequence":"additional","affiliation":[{"name":"Nankai University , , ,","place":["Tianjin, P. R. 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Front"},{"key":"2026090408101773800_cit3b","doi-asserted-by":"publisher","first-page":"372","DOI":"10.1002\/jlcr.4056","article-title":"Luminescence\nenhancement by deuterium","volume":"66","author":"Filer","year":"2023","journal-title":"J. Labelled Compd.\nRadiopharm"},{"key":"2026090408101773800_cit4a","doi-asserted-by":"publisher","first-page":"6634","DOI":"10.1021\/acs.chemrev.1c00795","article-title":"Recent Developments for the Deuterium\nand Tritium Labeling of Organic Molecules","volume":"122","author":"Kopf","year":"2022","journal-title":"Chem.\nRev"},{"key":"2026090408101773800_cit4b","doi-asserted-by":"publisher","DOI":"10.1002\/adsc.70185","article-title":"The Recent Progress in Introducing\nDeuterium with D2O","volume":"368","author":"Li","year":"2026","journal-title":"Adv. Synth. 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