{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,22]],"date-time":"2026-08-22T15:27:09Z","timestamp":1787412429140,"version":"build-2736575974"},"reference-count":35,"publisher":"American Chemical Society (ACS)","issue":"33","license":[{"start":{"date-parts":[[2026,8,10]],"date-time":"2026-08-10T00:00:00Z","timestamp":1786320000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2026,8,10]],"date-time":"2026-08-10T00:00:00Z","timestamp":1786320000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2026,8,10]],"date-time":"2026-08-10T00:00:00Z","timestamp":1786320000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-045"}],"funder":[{"DOI":"10.13039\/100012554","name":"Hubei Provincial Department of Education","doi-asserted-by":"publisher","award":["Q20231705"],"award-info":[{"award-number":["Q20231705"]}],"id":[{"id":"10.13039\/100012554","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["52403107"],"award-info":[{"award-number":["52403107"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026,8,21]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>A novel strategy for the green and efficient electrochemical synthesis of \u03b2-arylamino ketones has been developed through the reaction of readily available tertiary anilines with silyl enol ethers. This metal- and oxidant-free method operates under mild conditions and delivers \u03b2-arylamino ketones in high yields. The substrate scope with respect to various tertiary anilines and silyl enol ethers has been systematically investigated. Moreover, a continuous flow electrochemical reactor enabled the scalable synthesis of \u03b2-arylamino ketones, demonstrating the potential for industrial application. Mechanistic studies involving radical scavenging experiments and cyclic voltammetry suggest a reaction pathway involving anodically generated tertiary \u03b1-aminoalkyl radicals and subsequent C\u2013C bond formation.<\/jats:p>","DOI":"10.1021\/acs.joc.6c01064","type":"journal-article","created":{"date-parts":[[2026,8,11]],"date-time":"2026-08-11T03:02:33Z","timestamp":1786417353000},"page":"11356-11361","source":"Crossref","is-referenced-by-count":0,"title":["Electrochemical\nSynthesis of \u03b2-Arylamino\nKetones from Tertiary Anilines and Silyl Enol Ethers"],"prefix":"10.1021","volume":"91","author":[{"given":"Yingli","family":"Xu","sequence":"first","affiliation":[{"name":"Wuhan Textile University , , ,","place":["Wuhan, P. R. China, 430200"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhiqi","family":"Yang","sequence":"additional","affiliation":[{"name":"Wuhan Textile University , , ,","place":["Wuhan, P. R. China, 430200"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chenxi","family":"Cai","sequence":"additional","affiliation":[{"name":"Wuhan Textile University , , ,","place":["Wuhan, P. R. China, 430200"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wangqing","family":"Xiao","sequence":"additional","affiliation":[{"name":"Wuhan Textile University , , ,","place":["Wuhan, P. R. China, 430200"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chongduo","family":"Xiong","sequence":"additional","affiliation":[{"name":"Wuhan Textile University , , ,","place":["Wuhan, P. R. China, 430200"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3529-2659","authenticated-orcid":true,"given":"Ting","family":"Bai","sequence":"additional","affiliation":[{"name":"Wuhan Textile University , , ,","place":["Wuhan, P. R. China, 430200"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6045-5873","authenticated-orcid":true,"given":"Pengcheng","family":"Zhou","sequence":"additional","affiliation":[{"name":"Wuhan Textile University , , ,","place":["Wuhan, P. R. China, 430200"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"316","published-online":{"date-parts":[[2026,8,10]]},"reference":[{"key":"2026082211143296500_cit1a","doi-asserted-by":"publisher","first-page":"313","DOI":"10.1002\/cmdc.201200428","article-title":"Fueling open-source\ndrug discovery: 177 small-molecule leads against tuberculosis","volume":"8","author":"Ballell","year":"2013","journal-title":"ChemMedChem"},{"key":"2026082211143296500_cit1b","doi-asserted-by":"publisher","DOI":"10.1002\/cbdv.202000996","article-title":"Deoxyribonuclease I\nInhibitory Properties, Molecular Docking and Molecular Dynamics Simulations\nof 1-(Pyrrolidin-2-yl) propan-2-one Derivatives","volume":"18","author":"Ilic\u0301","year":"2021","journal-title":"Chem. Biodivers."},{"key":"2026082211143296500_cit1c","doi-asserted-by":"publisher","first-page":"3779","DOI":"10.1007\/s00044-012-0362-x","article-title":"Novel 2-(E)-substituted benzylidene-6-(N-substituted\naminomethyl) cyclohexanones and cyclohexanols as analgesic and anti-inflammatory\nagents","volume":"22","author":"Liu","year":"2013","journal-title":"Med. Chem. Res."},{"key":"2026082211143296500_cit2a","doi-asserted-by":"publisher","first-page":"2886","DOI":"10.1021\/ja029633z","article-title":"Chiral ligand-controlled asymmetric\nconjugate addition\nof lithium amides to enoates","volume":"125","author":"Doi","year":"2003","journal-title":"J. Am. Chem. Soc."},{"key":"2026082211143296500_cit2b","doi-asserted-by":"publisher","first-page":"1319","DOI":"10.1021\/ol0256163","article-title":"Transition metal salts-catalyzed\naza-Michael reactions of enones with carbamates","volume":"4","author":"Kobayashi","year":"2002","journal-title":"Org. Lett."},{"key":"2026082211143296500_cit2c","doi-asserted-by":"publisher","first-page":"975","DOI":"10.1055\/s-1998-1845","article-title":"Indium trichloride-catalyzed conjugate\naddition of amines to \u03b1, \u03b2-ethylenic compounds in water","volume":"1998","author":"Loh","year":"1998","journal-title":"Synlett"},{"key":"2026082211143296500_cit2d","doi-asserted-by":"publisher","first-page":"6274","DOI":"10.1021\/jo970435d","article-title":"Highly diastereoselective\nconjugate addition of lithium dialkylamides to \u03b1, \u03b2-unsaturated\nesters having a chiral center at the \u03b3-position","volume":"62","author":"Asao","year":"1997","journal-title":"J. Org. Chem."},{"key":"2026082211143296500_cit3a","doi-asserted-by":"publisher","first-page":"1215","DOI":"10.1021\/cr100280d","article-title":"Catalytic dehydrogenative cross-coupling:\nforming carbon\u2013carbon bonds by oxidizing two carbon\u2013hydrogen\nbonds","volume":"111","author":"Yeung","year":"2011","journal-title":"Chem. Rev."},{"key":"2026082211143296500_cit3b","doi-asserted-by":"publisher","first-page":"436","DOI":"10.1002\/asia.200900487","article-title":"Beyond\ntraditional cross couplings: the scope of the cross dehydrogenative\ncoupling reaction","volume":"5","author":"Scheuermann","year":"2010","journal-title":"Chem.\u2500Asian J."},{"key":"2026082211143296500_cit3c","doi-asserted-by":"publisher","first-page":"335","DOI":"10.1021\/ar800164n","article-title":"Cross-dehydrogenative\ncoupling (CDC): exploring C\u2013C bond formations beyond functional\ngroup transformations","volume":"42","author":"Li","year":"2009","journal-title":"Acc. Chem. Res."},{"key":"2026082211143296500_cit4","doi-asserted-by":"publisher","first-page":"3730","DOI":"10.1021\/ol901347t","article-title":"CuBr-catalyzed reaction of N, N-dimethylanilines\nand silyl enol ethers: an alternative route to \u03b2-arylamino ketones","volume":"11","author":"Huang","year":"2009","journal-title":"Org. Lett."},{"key":"2026082211143296500_cit5","doi-asserted-by":"publisher","first-page":"343","DOI":"10.1055\/s-0036-1588097","article-title":"Cobalt (II)-Catalyzed\nOxidative Coupling of Aromatic Tertiary Amines with Enol Silyl Ethers\nLeading to \u03b2-Aminoketone Derivatives","volume":"28","author":"Sakai","year":"2017","journal-title":"Synlett"},{"key":"2026082211143296500_cit6","doi-asserted-by":"publisher","first-page":"269","DOI":"10.1002\/adsc.201200999","article-title":"Antimony\/N-hydroxyphthalimide\nas\na catalyst system for cross-dehydrogenative coupling reactions under\naerobic conditions","volume":"355","author":"Tanoue","year":"2013","journal-title":"Adv. Synth. Catal."},{"key":"2026082211143296500_cit7","doi-asserted-by":"publisher","first-page":"2337","DOI":"10.1039\/c2cc17130a","article-title":"Visible light-induced oxidative coupling\nreaction: easy access to\nMannich-type products","volume":"48","author":"Zhao","year":"2012","journal-title":"Chem. Commun."},{"key":"2026082211143296500_cit8a","doi-asserted-by":"publisher","first-page":"13230","DOI":"10.1021\/acs.chemrev.7b00397","article-title":"Synthetic organic\nelectrochemical methods since 2000: on the verge of a renaissance","volume":"117","author":"Yan","year":"2017","journal-title":"Chem. Rev."},{"key":"2026082211143296500_cit8b","doi-asserted-by":"publisher","first-page":"1120","DOI":"10.31635\/ccschem.021.202101451","article-title":"Recent applications of homogeneous catalysis in electrochemical\norganic synthesis","volume":"4","author":"Cheng","year":"2022","journal-title":"CCS Chem."},{"key":"2026082211143296500_cit8c","doi-asserted-by":"publisher","first-page":"456","DOI":"10.1016\/j.matt.2023.12.014","article-title":"Designing efficient catalysts for electrocatalytic organic synthesis:\nFrom electronic structure to adsorption behavior","volume":"7","author":"Yang","year":"2024","journal-title":"Matter"},{"key":"2026082211143296500_cit8d","doi-asserted-by":"publisher","first-page":"3223","DOI":"10.1007\/s11426-024-2036-0","article-title":"Electrochemical conversion of organic\ncompounds and inorganic small molecules","volume":"67","author":"Zeng","year":"2024","journal-title":"Sci.\nChina Chem."},{"key":"2026082211143296500_cit8e","doi-asserted-by":"publisher","first-page":"2306","DOI":"10.1002\/tcr.202100048","article-title":"Electrochemically driven radical\nreactions: from direct electrolysis to molecular catalysis","volume":"21","author":"Chen","year":"2021","journal-title":"Chem. Rec."},{"key":"2026082211143296500_cit8f","doi-asserted-by":"publisher","first-page":"12264","DOI":"10.1021\/acs.chemrev.4c00464","article-title":"Electrophotocatalysis\nfor organic synthesis","volume":"124","author":"Lamb","year":"2024","journal-title":"Chem. Rev."},{"key":"2026082211143296500_cit9a","doi-asserted-by":"publisher","first-page":"13461","DOI":"10.1021\/jacs.5c00259","article-title":"Electrochemical\nBenzylic\nC\u2013H Carboxylation","volume":"147","author":"Zeng","year":"2025","journal-title":"J. Am. Chem. Soc."},{"key":"2026082211143296500_cit9b","doi-asserted-by":"publisher","first-page":"3564","DOI":"10.1038\/s41467-025-58948-3","article-title":"Electrocatalytic N\u2013C\u2013N\ncoupling over a hierarchically ordered open single-atom superstructure\ntoward organonitrogen synthesis","volume":"16","author":"He","year":"2025","journal-title":"Nat. Commun."},{"key":"2026082211143296500_cit9c","doi-asserted-by":"publisher","first-page":"44","DOI":"10.1038\/s41557-024-01695-7","article-title":"Stereoselective\namino alcohol synthesis via chemoselective electrocatalytic radical\ncross-couplings","volume":"17","author":"Sun","year":"2025","journal-title":"Nat. Chem."},{"key":"2026082211143296500_cit9d","doi-asserted-by":"publisher","DOI":"10.1126\/sciadv.aaz0590","article-title":"Electrochemical oxidation-induced etherification via C(sp3)\u2013H\/O\u2013H\ncross-coupling","volume":"6","author":"Wang","year":"2020","journal-title":"Sci. Adv."},{"key":"2026082211143296500_cit9e","doi-asserted-by":"publisher","first-page":"23297","DOI":"10.1021\/jacs.5c08109","article-title":"Electrochemical\nDirect Hydroxylation of Benzylic C\u2013H Bonds Assisted by HFIP","volume":"147","author":"Zhang","year":"2025","journal-title":"J. Am. Chem. Soc."},{"key":"2026082211143296500_cit10a","doi-asserted-by":"publisher","first-page":"1252","DOI":"10.1021\/acs.orglett.2c04335","article-title":"K2S2O8-Induced [4 + 2] Annulation\nof Tertiary Anilines and Alkenes toward Tetrahydroquinolines","volume":"25","author":"Hu","year":"2023","journal-title":"Org. Lett."},{"key":"2026082211143296500_cit10b","doi-asserted-by":"publisher","first-page":"7178","DOI":"10.1021\/acs.orglett.2c02900","article-title":"Direct Reductive Arylation\nof Imines with Electron-Deficient (Hetero) Arenes via Electrosynthesis\nto Access Benzylic Amines","volume":"24","author":"Zeng","year":"2022","journal-title":"Org. Lett."},{"key":"2026082211143296500_cit11a","doi-asserted-by":"publisher","first-page":"4488","DOI":"10.1021\/acs.joc.4c02283","article-title":"Electrochemical Synthesis of \u03b2-Keto\nSulfones from Enol Acetates and Sulfonyl Hydrazides","volume":"90","author":"Yang","year":"2025","journal-title":"J. Org. Chem."},{"key":"2026082211143296500_cit11b","doi-asserted-by":"publisher","first-page":"113614","DOI":"10.1016\/j.mcat.2023.113614","article-title":"Electrochemically driven aerobic\noxygenation of alkylarenes to carbonyl compounds","volume":"550","author":"Xu","year":"2023","journal-title":"Mol. Catal."},{"key":"2026082211143296500_cit11c","doi-asserted-by":"publisher","first-page":"1681","DOI":"10.1039\/D2CC06552E","article-title":"Electrochemically driven [4 + 2] benzannulation: synthesis of polycyclic\n(hetero) aromatic compounds","volume":"59","author":"Liu","year":"2023","journal-title":"Chem. Commun."},{"key":"2026082211143296500_cit11d","doi-asserted-by":"publisher","first-page":"2215","DOI":"10.1039\/D1QO01765A","article-title":"Electrochemical\nsynthesis for \u03b1-arylation of ketones using enol acetates and\naryl diazonium salts","volume":"9","author":"Zhou","year":"2022","journal-title":"Org. Chem. Front."},{"key":"2026082211143296500_cit12a","doi-asserted-by":"publisher","first-page":"6650","DOI":"10.1002\/anie.201901610","article-title":"Continuous-Flow\nElectrosynthesis of Benzofused S-Heterocycles by Dehydrogenative C\u2013S\nCross-Coupling","volume":"58","author":"Huang","year":"2019","journal-title":"Angew. Chem., Int. Ed."},{"key":"2026082211143296500_cit12b","doi-asserted-by":"publisher","first-page":"3945","DOI":"10.1038\/s41467-022-31634-4","article-title":"Electrochemical aromatic C\u2013H hydroxylation in continuous flow","volume":"13","author":"Long","year":"2022","journal-title":"Nat. Commun."},{"key":"2026082211143296500_cit13a","doi-asserted-by":"publisher","first-page":"4870","DOI":"10.1039\/C8GC02463D","article-title":"Electrochemical oxidative [4 + 2]\nannulation of tertiary anilines and alkenes for the synthesis of tetrahydroquinolines","volume":"20","author":"Huang","year":"2018","journal-title":"Green Chem."},{"key":"2026082211143296500_cit13b","doi-asserted-by":"publisher","first-page":"3964","DOI":"10.1039\/D2GC00530A","article-title":"Electrochemical synthesis of \u03b1-amino\namides via C(sp3)\u2013H bond activation","volume":"24","author":"Guan","year":"2022","journal-title":"Green Chem."}],"container-title":["The Journal of Organic Chemistry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/pubs.acs.org\/doi\/pdf\/10.1021\/acs.joc.6c01064","content-type":"application\/pdf","content-version":"vor","intended-application":"unspecified"},{"URL":"https:\/\/pubs.acs.org\/joceah\/article-pdf\/91\/33\/11356\/66482311\/acs.joc.6c01064.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/pubs.acs.org\/joceah\/article-pdf\/91\/33\/11356\/66482311\/acs.joc.6c01064.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,22]],"date-time":"2026-08-22T15:15:46Z","timestamp":1787411746000},"score":1,"resource":{"primary":{"URL":"https:\/\/pubs.acs.org\/joceah\/article\/91\/33\/11356\/5251775\/Electrochemical-Synthesis-of-Arylamino-Ketones"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,8,10]]},"references-count":35,"journal-issue":{"issue":"33","published-online":{"date-parts":[[2026,8,10]]},"published-print":{"date-parts":[[2026,8,21]]}},"URL":"https:\/\/doi.org\/10.1021\/acs.joc.6c01064","relation":{},"ISSN":["0022-3263","1520-6904"],"issn-type":[{"value":"0022-3263","type":"print"},{"value":"1520-6904","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,8,10]]}}}