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These thermochemical values have not heretofore been measured and provide experimental data to benchmark the theoretical results. Pf HG(X)PRT is an antimalarial target; our gas-phase results lend insight into the Pf HG(X)PRT mechanism, providing a potential means of predicting enzyme substrate activity.<\/jats:p>","DOI":"10.1021\/acs.joc.6c01124","type":"journal-article","created":{"date-parts":[[2026,9,9]],"date-time":"2026-09-09T19:02:16Z","timestamp":1788980536000},"page":"13339-13350","source":"Crossref","is-referenced-by-count":0,"title":["Gas Phase Studies\nof Purine Base Analogs: Intrinsic\nProperties and Hypoxanthine-Guanine-(Xanthine) Phosphoribosyltransferase\n(HG(X)PRT)"],"prefix":"10.1021","volume":"91","author":[{"given":"Xiao","family":"Ding","sequence":"first","affiliation":[{"name":"The State University of New Jersey , , , ,","place":["New Brunswick, New Jersey, United States, 08901"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lanxin","family":"Zhang","sequence":"additional","affiliation":[{"name":"The State University of New Jersey , , , ,","place":["New Brunswick, New Jersey, United States, 08901"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"G. S. 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