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A series of target products were afforded in moderate to excellent yields. Preliminary biological evaluation revealed that several synthesized compounds exhibit significant anti-inflammatory activity in LPS-stimulated RAW264.7 cells. In particular, compound 3h displayed potent inhibition of NO production along with suppression of pro-inflammatory cytokines.<\/jats:p>","DOI":"10.1021\/acs.joc.6c01129","type":"journal-article","created":{"date-parts":[[2026,8,20]],"date-time":"2026-08-20T03:01:20Z","timestamp":1787194880000},"page":"11978-11991","source":"Crossref","is-referenced-by-count":1,"title":["A Cascade Annulation\nfor the Synthesis of 11\n                    <i>H<\/i>\n                    -Indolo[3,2-\n                    <i>c<\/i>\n                    ]quinolines\nand In Vitro Anti-Inflammatory Assays"],"prefix":"10.1021","volume":"91","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3963-7346","authenticated-orcid":true,"given":"Caixia","family":"Xie","sequence":"first","affiliation":[{"name":"Shandong University of Technology , , 266 West Xincun Road , ,","place":["Zibo, P. R. 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China, 255049"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Junwei","family":"Du","sequence":"additional","affiliation":[{"name":"Shandong University of Technology , , 266 West Xincun Road , ,","place":["Zibo, P. R. China, 255049"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiangwei","family":"Meng","sequence":"additional","affiliation":[{"name":"Zibo Central Hospital Affiliated to Binzhou Medical University , , 54 Gongqingtuan Xi Road , ,","place":["Zibo, P. R. China, 255036"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"316","published-online":{"date-parts":[[2026,8,19]]},"reference":[{"key":"2026090408095006800_cit1a","doi-asserted-by":"publisher","first-page":"2851","DOI":"10.1021\/acs.jafc.1c07536","article-title":"Design, synthesis,\nand antimicrobial activity of quindoline derivatives inspired by the\ncryptolepine alkaloid","volume":"70","author":"Chu","year":"2022","journal-title":"J. Agric. 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