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Herein, we report an oxidation-triggered carbon-atom insertion into acyl chlorides using bench-stable N-isocyaniminophosphorane (PINC). Unlike our previous thermal\/Rh-catalyzed protocol, this method proceeds at room temperature to afford cyclic \u03b1-chloro ketones. Mechanistic studies support oxidation-induced diazo formation from a phosphazine intermediate, followed by carbene generation.<\/jats:p>","DOI":"10.1021\/acs.joc.6c01151","type":"journal-article","created":{"date-parts":[[2026,8,5]],"date-time":"2026-08-05T13:02:50Z","timestamp":1785934970000},"page":"11214-11218","source":"Crossref","is-referenced-by-count":0,"title":["Oxidation-Triggered\nSingle-Carbon Atom Doping into\nAcyl Chlorides Using\n                    <i>N<\/i>\n                    -Isocyanide"],"prefix":"10.1021","volume":"91","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2046-4596","authenticated-orcid":true,"given":"Hayato","family":"Fujimoto","sequence":"first","affiliation":[{"name":"The University of Osaka , , , ,","place":["Suita, Osaka, Japan, 565-0871"]},{"name":"The University of Osaka , , , ,","place":["Suita, Osaka, Japan, 565-0871"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Reona","family":"Ikeda","sequence":"additional","affiliation":[{"name":"The University of Osaka , , , ,","place":["Suita, Osaka, Japan, 565-0871"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8415-2225","authenticated-orcid":true,"given":"Mamoru","family":"Tobisu","sequence":"additional","affiliation":[{"name":"The University of Osaka , , , ,","place":["Suita, Osaka, Japan, 565-0871"]},{"name":"The University of Osaka , , , ,","place":["Suita, Osaka, Japan, 565-0871"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"316","published-online":{"date-parts":[[2026,8,4]]},"reference":[{"key":"2026081410091333900_cit1a","doi-asserted-by":"publisher","first-page":"2769","DOI":"10.1002\/ejoc.201900098","article-title":"Recent Developments\nin Radical-Mediated Transformations\nof Organohalides","volume":"2019","author":"Lekkala","year":"2019","journal-title":"Eur. 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