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Although many methods for synthesizing enamides have been developed, the obtained enamides usually suffer from poor selectivity and low yield. Herein, we report a divergent and selective isomerization reaction of N-allylamides under a visible light-driven photoredox cobalt-catalyzed system. This strategy enables the efficient synthesis of various enamides with excellent stereoselectivity. Notably, by simply switching the ligand in the reaction, both E- and Z-isomers can be obtained with high stereoselectivity (E\/Z up to &amp;gt;20:1; Z\/E up to 5.3:1) and good yields (58\u201392%) under mild conditions, along with a broad substrate scope and good functional group tolerance.<\/jats:p>","DOI":"10.1021\/acs.joc.6c01183","type":"journal-article","created":{"date-parts":[[2026,7,21]],"date-time":"2026-07-21T14:52:43Z","timestamp":1784645563000},"page":"10509-10517","source":"Crossref","is-referenced-by-count":0,"title":["Photoredox\/Cobalt\nCooperative\nCatalysis for Divergent\nSelective Isomerization of\n                    <i>N<\/i>\n                    -Allylamides"],"prefix":"10.1021","volume":"91","author":[{"given":"Xingxing","family":"Zhu","sequence":"first","affiliation":[{"name":"University of Science and Technology of China , , ,","place":["Hefei, China, 230001"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mingbao","family":"Zhang","sequence":"additional","affiliation":[{"name":"Hefei University of Technology and Anhui Province Key Laboratory of Value-Added Catalytic Conversion and Reaction Engineering , , ,","place":["Hefei, China, 230009"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuan-Gen","family":"Gu","sequence":"additional","affiliation":[{"name":"Hefei University of Technology and Anhui Province Key Laboratory of Value-Added Catalytic Conversion and Reaction Engineering , , ,","place":["Hefei, China, 230009"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0004-2945-7079","authenticated-orcid":true,"given":"Yang\u2019en","family":"You","sequence":"additional","affiliation":[{"name":"Hefei University of Technology and Anhui Province Key Laboratory of Value-Added Catalytic Conversion and Reaction Engineering , , ,","place":["Hefei, China, 230009"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"316","published-online":{"date-parts":[[2026,7,21]]},"reference":[{"key":"2026073108244807000_cit1a","doi-asserted-by":"publisher","first-page":"10164","DOI":"10.1021\/ja404578u","article-title":"Isolation and First Total Synthesis of PM050489 and\nPM060184, Two\nNew Marine Anticancer Compounds","volume":"135","author":"Marti\u0301n","year":"2013","journal-title":"J. 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