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Through in situ halogen exchange for activation of polyfluoroalkyl bromides, a photocatalytic cascade cyclization using 4-bromo-3,3,4,4-tetrafluorobutene-1 (BTFB) as the polyfluoroalkyl radical source is described for the first time. It introduces polyfluoroalkyl and terminal alkenes into N-heterocycles in a single operation without metal catalysts or redox reagents, featuring broad substrate scope and late-stage functionalization applicability.<\/jats:p>","DOI":"10.1021\/acs.joc.6c01213","type":"journal-article","created":{"date-parts":[[2026,8,19]],"date-time":"2026-08-19T06:02:12Z","timestamp":1787119332000},"page":"11742-11753","source":"Crossref","is-referenced-by-count":0,"title":["BTFB Participates\nin Photocatalytic Cascade Cyclization\nto Construct Polyfluoroalkyl-Substituted Nitrogen-Containing Heterocyclic\nCompounds"],"prefix":"10.1021","volume":"91","author":[{"given":"Hao","family":"Zheng","sequence":"first","affiliation":[{"name":"Zhejiang University of Technology , , ,","place":["Hangzhou, China, 310014"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jia-Mei","family":"Ni","sequence":"additional","affiliation":[{"name":"Zhejiang University of Technology , , ,","place":["Hangzhou, China, 310014"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chu-Chu","family":"Xie","sequence":"additional","affiliation":[{"name":"Zhejiang University of Technology , , ,","place":["Hangzhou, China, 310014"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9615-8536","authenticated-orcid":true,"given":"Zhi-Wei","family":"Chen","sequence":"additional","affiliation":[{"name":"Zhejiang University of Technology , , ,","place":["Hangzhou, China, 310014"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"316","published-online":{"date-parts":[[2026,8,19]]},"reference":[{"issue":"4","key":"2026090200065600100_cit1","doi-asserted-by":"publisher","first-page":"2432","DOI":"10.1021\/cr4002879","article-title":"Fluorine in Pharmaceutical Industry: Fluorine-Containing Drugs Introduced\nto the Market in the Last Decade (2001\u20132011)","volume":"114","author":"Wang","year":"2014","journal-title":"Chem. 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