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Mechanistic studies revealed that PhI(OAc)2 played important roles in the formation of CF3-containing bispirocyclic 2-pyrrolidinones in the oxidation and dearomatization steps. The present method features high regioselectivity and diastereoselectivity, three rings and three carbon stereocenters formation, and novel bispirocyclic 2-pyrrolidinone scaffolds.<\/jats:p>","DOI":"10.1021\/acs.joc.6c01266","type":"journal-article","created":{"date-parts":[[2026,9,3]],"date-time":"2026-09-03T09:14:43Z","timestamp":1788426883000},"page":"12205-12215","source":"Crossref","is-referenced-by-count":0,"title":["Synthesis of CF3-Containing Bispirocyclic\n2-Pyrrolidinones through Cycloaddition and Oxidative Dearomatization\nfrom Nitrones and 1-Alkynyl-2-naphthols"],"prefix":"10.1021","volume":"91","author":[{"given":"Shan","family":"Chen","sequence":"first","affiliation":[{"name":"Guangxi Normal University , , 15 Yu Cai Road , ,","place":["Guilin, China, 541004"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yong-Le","family":"Chen","sequence":"additional","affiliation":[{"name":"Guangxi Normal University , , 15 Yu Cai Road , ,","place":["Guilin, China, 541004"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yan","family":"Li","sequence":"additional","affiliation":[{"name":"Guangxi Normal University , , 15 Yu Cai Road , ,","place":["Guilin, China, 541004"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiao-Rui","family":"Xu","sequence":"additional","affiliation":[{"name":"Guangxi Normal University , , 15 Yu Cai Road , ,","place":["Guilin, China, 541004"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7981-2495","authenticated-orcid":true,"given":"Fang-Xin","family":"Wang","sequence":"additional","affiliation":[{"name":"Guangxi Normal University , , 15 Yu Cai Road , ,","place":["Guilin, China, 541004"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guoao","family":"Wang","sequence":"additional","affiliation":[{"name":"Nanjing Forestry University , , ,","place":["Nanjing, China, 210037"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qing-Qing","family":"Liu","sequence":"additional","affiliation":[{"name":"Bengbu Medical University , , 2600 Donghai Avenue , ,","place":["Bengbu, China, 233030"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lei","family":"Xie","sequence":"additional","affiliation":[{"name":"Yulin Orthopedic Hospital of Integrated Traditional Chinese and Western Medicine , 70 Wenti North Road , ,","place":["Yulin, China, 537000"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4005-2249","authenticated-orcid":true,"given":"Dong-Liang","family":"Mo","sequence":"additional","affiliation":[{"name":"Guangxi Normal University , , 15 Yu Cai Road , ,","place":["Guilin, China, 541004"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"316","published-online":{"date-parts":[[2026,9,1]]},"reference":[{"key":"2026091109113605400_cit1a","doi-asserted-by":"publisher","first-page":"117368","DOI":"10.1016\/j.ejmech.2025.117368","article-title":"Spirocyclic\ncompounds as innovative\ntools in drug discovery for medicinal chemists","volume":"287","author":"Varela","year":"2025","journal-title":"Eur. 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