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Their structures were elucidated using NMR, HRESIMS, ECD calculations, and X-ray diffraction analysis. Compounds 1\u201311 featured 5\/5\/7\/5-fused ring frameworks bearing a 1,3,5-heptatriyne side chain by C\u2013C linkages, which were biosynthetically generated by [4 + 2] Diels\u2013Alder cycloadditions. The investigation of antihepatoma activity suggested that compound 4 exhibited significant inhibition on HepG2, Huh7, and SK-Hep-1 cell lines, with IC50 values of 22.8 \u00b1 1.8, 31.7 \u00b1 1.4, and 26.3 \u00b1 3.0 \u03bcM, respectively.<\/jats:p>","DOI":"10.1021\/acs.joc.6c01294","type":"journal-article","created":{"date-parts":[[2026,8,4]],"date-time":"2026-08-04T14:32:58Z","timestamp":1785853978000},"page":"11086-11094","source":"Crossref","is-referenced-by-count":1,"title":["Artemisiyneolides\nA\u2013K, Guaiane Sesquiterpenoid-Heptatriyne\nHybrids through C\u2013C Linkages from\n                    <i>Artemisia sieversiana<\/i>\n                    with Antihepatoma Activity"],"prefix":"10.1021","volume":"91","author":[{"given":"Yan-Mei","family":"Weng","sequence":"first","affiliation":[{"name":"Kunming Institute of Botany, Chinese Academy of Sciences , , ,","place":["Kunming, People\u2019s Republic of China, 650201"]},{"name":"University of Chinese Academy of Sciences , ,","place":["Beijing, People\u2019s Republic of China, 100049"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tian-Ze","family":"Li","sequence":"additional","affiliation":[{"name":"Kunming Institute of Botany, Chinese Academy of Sciences , , ,","place":["Kunming, People\u2019s Republic of China, 650201"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yun-Bao","family":"Ma","sequence":"additional","affiliation":[{"name":"Kunming Institute of Botany, Chinese Academy of Sciences , , ,","place":["Kunming, People\u2019s Republic of China, 650201"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hao-Wei","family":"Zhang","sequence":"additional","affiliation":[{"name":"Kunming Institute of Botany, Chinese Academy of Sciences , , ,","place":["Kunming, People\u2019s Republic of China, 650201"]},{"name":"University of Chinese Academy of Sciences , ,","place":["Beijing, People\u2019s Republic of China, 100049"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5781-7511","authenticated-orcid":true,"given":"Ji-Jun","family":"Chen","sequence":"additional","affiliation":[{"name":"Kunming Institute of Botany, Chinese Academy of Sciences , , ,","place":["Kunming, People\u2019s Republic of China, 650201"]},{"name":"University of Chinese Academy of Sciences , ,","place":["Beijing, People\u2019s Republic of China, 100049"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"316","published-online":{"date-parts":[[2026,8,1]]},"reference":[{"key":"2026081410104291100_cit1","doi-asserted-by":"publisher","first-page":"229","DOI":"10.3322\/caac.21834","article-title":"Global cancer statistics 2022: GLOBOCAN\nestimates of incidence and mortality worldwide for 36 cancers in 185\ncountries","volume":"74","author":"Bray","year":"2024","journal-title":"Ca-Cancer J. 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