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However, general synthetic strategies for their construction remain underexplored. We herein describe a route to 4-arylpiperidines from simple pyridines and aryl iodides. NiH-catalyzed regioselective hydroarylation of 1,2-dihydropyridines served as the key step to access various 4-aryl tetrahydropyridines, which were readily converted to diverse 4-arylpiperidines via hydrogenation or functionalization of the enamine double bond. This protocol features direct use of iodoarenes as arylating reagents, mild conditions, and excellent functional group tolerance.<\/jats:p>","DOI":"10.1021\/acs.joc.6c01490","type":"journal-article","created":{"date-parts":[[2026,8,10]],"date-time":"2026-08-10T07:02:44Z","timestamp":1786345364000},"page":"11597-11602","source":"Crossref","is-referenced-by-count":0,"title":["NiH Catalysis-Enabled\nSynthesis of 4-Arylpiperidines\nfrom Pyridines and Aryl Iodides"],"prefix":"10.1021","volume":"91","author":[{"given":"Xinshuai","family":"Liu","sequence":"first","affiliation":[{"name":"Hebei Normal University , , ,","place":["Shijiazhuang, China, 050024"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Baoye","family":"Zhang","sequence":"additional","affiliation":[{"name":"Hebei Normal University , , ,","place":["Shijiazhuang, China, 050024"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mingxia","family":"Gao","sequence":"additional","affiliation":[{"name":"Hebei Normal University , , ,","place":["Shijiazhuang, China, 050024"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0009-6822-5779","authenticated-orcid":true,"given":"Fang-Fang","family":"Feng","sequence":"additional","affiliation":[{"name":"Hebei Normal University , , ,","place":["Shijiazhuang, China, 050024"]},{"name":"Chemistry Postdoctoral Research Station at Hebei Normal University , ,","place":["Shijiazhuang, China, 050024"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0000-0021-2634","authenticated-orcid":true,"given":"Yongbing","family":"Liu","sequence":"additional","affiliation":[{"name":"Hebei Normal University , , ,","place":["Shijiazhuang, China, 050024"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"316","published-online":{"date-parts":[[2026,8,10]]},"reference":[{"key":"2026082211142150900_cit1a","doi-asserted-by":"publisher","first-page":"10257","DOI":"10.1021\/jm501100b","article-title":"Analysis\nof Structural Diversity, Substitution Patterns, and Frequency of Nitrogen\nHeterocycles among U.S. FDA Approved Pharmaceuticals","volume":"57","author":"Vitaku","year":"2014","journal-title":"J. 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