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Both synthetic protocols provide straightforward, practical, and environmentally benign routes to this important class of biologically and synthetically valuable heterocycles. The noteworthy advantages of this dual synthetic approach include mild reaction conditions, the avoidance of using metal catalysts and\/or oxidants, organic solvents, and heating, significantly shorter reaction times (in minutes), good to excellent yields with high regioselectivity, a broad substrate scope, excellent functional group tolerance, reusability of the solid surface (in the mechanochemical method), and facile gram-scale applications. Additionally, the synthetic utility of the methodology was demonstrated through the transformation of some selected 1,2,4-thiadiazole derivatives to a variety of structurally diverse and biologically relevant molecular scaffolds.<\/jats:p>","DOI":"10.1021\/acs.joc.6c01511","type":"journal-article","created":{"date-parts":[[2026,9,2]],"date-time":"2026-09-02T07:18:25Z","timestamp":1788333505000},"page":"12327-12343","source":"Crossref","is-referenced-by-count":0,"title":["Sono- and Mechanochemical\nTandem Synthesis of Diversely\nFunctionalized 1,2,4-Thiadiazoles: A Robust and Straightforward Dual\nSynthetic Approach"],"prefix":"10.1021","volume":"91","author":[{"given":"Soma","family":"Ghosh","sequence":"first","affiliation":[{"name":"Department of Chemistry, Visva-Bharati (a Central University) , , , ,","place":["Santiniketan, West Bengal, India, 731 235"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Debojyoti","family":"Mukherjee","sequence":"additional","affiliation":[{"name":"Department of Chemistry, Visva-Bharati (a Central University) , , , ,","place":["Santiniketan, West Bengal, India, 731 235"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pintu","family":"Karmakar","sequence":"additional","affiliation":[{"name":"Department of Chemistry, Visva-Bharati (a Central University) , , , ,","place":["Santiniketan, West Bengal, India, 731 235"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9925-6281","authenticated-orcid":true,"given":"Goutam","family":"Brahmachari","sequence":"additional","affiliation":[{"name":"Department of Chemistry, Visva-Bharati (a Central University) , , , ,","place":["Santiniketan, West Bengal, India, 731 235"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"316","published-online":{"date-parts":[[2026,8,28]]},"reference":[{"key":"2026091109115688600_cit1a","doi-asserted-by":"publisher","first-page":"960","DOI":"10.30799\/jacs.S208.26120308","article-title":"Heterocyclic\nSystems in Modern Material Design: A Comprehensive Review","volume":"12","author":"Mathure","year":"2026","journal-title":"Indian J. 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