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Remarkably, despite their disparate nucleophilic profiles, both alcohols and amines individually engage in the skeletal-editing reaction through deliberate switching of the Br\u00f8nsted acid catalysts, demonstrating a broad scope of substrates with high functional group tolerance. The reaction proceeds under mild, operationally simple conditions, enabling the transformation of planar 2D aromatic furans into 3D \u03b3-lactam with complete regioselectivity.<\/jats:p>","DOI":"10.1021\/acs.joc.6c01526","type":"journal-article","created":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T18:28:38Z","timestamp":1788287318000},"page":"12354-12365","source":"Crossref","is-referenced-by-count":0,"title":["Skeletal Editing\nof Azofurans Enabling the Synthesis\nof Alkoxylated and Aminated \u03b3-Lactams"],"prefix":"10.1021","volume":"91","author":[{"given":"Yu-Xuan","family":"Li","sequence":"first","affiliation":[{"name":"Jiangsu Normal University , , ,","place":["Xuzhou, China, 221116"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yin","family":"Zhang","sequence":"additional","affiliation":[{"name":"Jiangsu Normal University , , ,","place":["Xuzhou, China, 221116"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jing-Wen","family":"Li","sequence":"additional","affiliation":[{"name":"Jiangsu Normal University , , ,","place":["Xuzhou, China, 221116"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xin","family":"Shen","sequence":"additional","affiliation":[{"name":"Jiangsu Normal University , , ,","place":["Xuzhou, China, 221116"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0004-9962-2316","authenticated-orcid":true,"given":"Ke","family":"Chen","sequence":"additional","affiliation":[{"name":"Jiangsu Normal University , , ,","place":["Xuzhou, China, 221116"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wen-Juan","family":"Hao","sequence":"additional","affiliation":[{"name":"Jiangsu Normal University , , ,","place":["Xuzhou, China, 221116"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3878-515X","authenticated-orcid":true,"given":"Bo","family":"Jiang","sequence":"additional","affiliation":[{"name":"Jiangsu Normal University , , ,","place":["Xuzhou, China, 221116"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"316","published-online":{"date-parts":[[2026,8,27]]},"reference":[{"key":"2026091109105833800_cit1","doi-asserted-by":"publisher","first-page":"1292","DOI":"10.1021\/jm00220a013","article-title":"Prostaglandin isosteres. 1. 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