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We report here a new and unexpected T3P-mediated one-pot transformation of amines and \u03b2-ketoesters into 4-pyridones via an enaminoester cascade cyclization process. This method affords structurally diverse and readily multi-tailorable 4-pyridones with up to 99% yields in 1 h at 70 \u00b0C, providing rapid access to a pharmaceutically significant heterocyclic motif. Furthermore, this method shows a low E-factor (5.18), a low process mass intensity (PMI, 6.18), and an excellent GreenScore (86). To the best of our knowledge, this study presents the first highly efficient and straightforward multicomponent synthesis of 4-pyridones using readily available substrates.<\/jats:p>","DOI":"10.1021\/acs.joc.6c01549","type":"journal-article","created":{"date-parts":[[2026,10,15]],"date-time":"2026-10-15T22:01:21Z","timestamp":1792101681000},"page":"14167-14182","source":"Crossref","is-referenced-by-count":0,"title":["Unexpected T3P-Mediated Enaminoester Cascade Cyclization to Access 4-Pyridones"],"prefix":"10.1021","volume":"91","author":[{"given":"Manubolu","family":"Guravaiah","sequence":"first","affiliation":[{"name":"Andhra University , , ,","place":["Visakhapatnam, India, 530003"]},{"name":"Services Aragen Life Sciences Pvt. 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