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Using a Cu(I)\/Segphos complex, this protocol provides diverse chiral fluorinated 2-heterocyclic pyrrolidines in high yields (up to 99%) with excellent stereoselectivity (up to 98% ee, &amp;gt;20:1 dr). This method is compatible with various heteroaryl groups and complex natural products. Notably, these scaffolds exhibit potent antifungal activity against Magnaporthe oryzae, with the lead compound 4a outperforming the commercial fungicide isoprothiolane by 50% in EC50 values.<\/jats:p>","DOI":"10.1021\/acs.joc.6c01562","type":"journal-article","created":{"date-parts":[[2026,9,4]],"date-time":"2026-09-04T23:01:56Z","timestamp":1788562916000},"page":"12674-12680","source":"Crossref","is-referenced-by-count":0,"title":["Synthesis of Bioactive\nFluorinated 2-Heterocyclic\nPyrrolidines via Copper(I)-Catalyzed Asymmetric 1,3-Dipolar Cycloaddition\nof Azomethine Ylides"],"prefix":"10.1021","volume":"91","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7572-1000","authenticated-orcid":true,"given":"Yu","family":"Chen","sequence":"first","affiliation":[{"name":"Huazhong Agricultural University , , ,","place":["Wuhan, China, 430070"]},{"name":"The University of Nottingham Ningbo China , , .","place":["Ningbo, P. R. 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