{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:22Z","timestamp":1790812822820,"version":"4.1.0"},"reference-count":29,"publisher":"American Chemical Society (ACS)","issue":"35","license":[{"start":{"date-parts":[[2026,8,24]],"date-time":"2026-08-24T00:00:00Z","timestamp":1787529600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100016545","name":"Roche Diagnostics","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100016545","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000062","name":"National Institute of Diabetes and Digestive and Kidney Diseases","doi-asserted-by":"publisher","award":["TL1 DK136047"],"award-info":[{"award-number":["TL1 DK136047"]}],"id":[{"id":"10.13039\/100000062","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100008227","name":"Achievement Rewards for College Scientists Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100008227","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000057","name":"National Institute of General Medical Sciences","doi-asserted-by":"publisher","award":["GM119426"],"award-info":[{"award-number":["GM119426"]}],"id":[{"id":"10.13039\/100000057","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026,9,4]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>We report the first total synthesis of the cembranoid diterpenes knightol, knightal, and knightol acetate isolated from the Caribbean Sea Whip, Eunicea knighti. Highlights of the synthesis include leveraging farnesol as a feedstock starting material, a late-stage Shi epoxidation, and a penultimate Horner-Wadsworth-Emmons macrocyclization. Biological studies reveal modest biofilm inhibitory activity against Staphylococcus aureus for the most active member, (\u2212)-knightol.<\/jats:p>","DOI":"10.1021\/acs.joc.6c01571","type":"journal-article","created":{"date-parts":[[2026,8,30]],"date-time":"2026-08-30T17:54:06Z","timestamp":1788112446000},"page":"12120-12125","source":"Crossref","is-referenced-by-count":1,"title":["Total Synthesis\nand Biofilm Inhibitory Studies of\nKnightine Cembranoid Diterpenes"],"prefix":"10.1021","volume":"91","author":[{"given":"Learnmore","family":"Jeremia","sequence":"first","affiliation":[{"name":"Emory University , , , ,","place":["Atlanta, Georgia, United States, 30322"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elise L.","family":"Bezold","sequence":"additional","affiliation":[{"name":"Emory University , , , ,","place":["Atlanta, Georgia, United States, 30322"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5198-7744","authenticated-orcid":true,"given":"William M.","family":"Wuest","sequence":"additional","affiliation":[{"name":"Emory University , , , ,","place":["Atlanta, Georgia, United States, 30322"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"316","published-online":{"date-parts":[[2026,8,24]]},"reference":[{"issue":"10369","key":"2026090408095346500_cit1","doi-asserted-by":"publisher","first-page":"2221","DOI":"10.1016\/S0140-6736(22)02185-7","article-title":"Global Mortality Associated with 33 Bacterial Pathogens in 2019:\nA Systematic Analysis for the Global Burden of Disease Study 2019","volume":"400","author":"Ikuta","year":"2022","journal-title":"Lancet"},{"issue":"10325","key":"2026090408095346500_cit2","doi-asserted-by":"publisher","first-page":"629","DOI":"10.1016\/S0140-6736(21)02724-0","article-title":"Global Burden of Bacterial Antimicrobial Resistance\nin 2019: A Systematic Analysis","volume":"399","author":"Murray","year":"2022","journal-title":"Lancet"},{"issue":"DEC","key":"2026090408095346500_cit3","doi-asserted-by":"publisher","DOI":"10.3389\/fcimb.2014.00178","article-title":"Staphylococcus Aureus Biofilms: Recent Developments in Biofilm Dispersal","volume":"4","author":"Lister","year":"2014","journal-title":"Front. 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