{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,2]],"date-time":"2026-10-02T12:57:31Z","timestamp":1790945851022,"version":"4.1.0"},"reference-count":50,"publisher":"American Chemical Society (ACS)","issue":"39","license":[{"start":{"date-parts":[[2026,9,17]],"date-time":"2026-09-17T00:00:00Z","timestamp":1789603200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001824","name":"Grantov? Agentura Cesk? 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Under the optimized reaction conditions, a broad range of spiropyrrolidines were obtained in good combined yields (up to 83%), with high diastereoselectivities (up to 1:12 dr) and enantioselectivities reaching 99% ee. The developed methodology tolerates various substitutions on both of the reaction partners. Furthermore, selected synthetic transformations demonstrated the utility of the obtained spiropyrrolidines for further derivatization while retaining the enantiomeric purity. This work highlights the potential of synergistic CPA\/transition-metal catalysis for the efficient construction of structurally complex chiral spiropyrrolidine scaffolds.<\/jats:p>","DOI":"10.1021\/acs.joc.6c01686","type":"journal-article","created":{"date-parts":[[2026,9,18]],"date-time":"2026-09-18T03:01:31Z","timestamp":1789700491000},"page":"13215-13227","source":"Crossref","is-referenced-by-count":0,"title":["Enantioselective\nSynthesis of Spiropyrrolidines by\nSynergistic Catalysis"],"prefix":"10.1021","volume":"91","author":[{"given":"Michael","family":"Franc","sequence":"first","affiliation":[{"name":"Faculty of Science, Charles University , , Hlavova 2030 , ,","place":["Praha 2, Czech Republic, 128 43"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9612-9831","authenticated-orcid":true,"given":"Ivana","family":"Ci\u0301sar\u030cova\u0301","sequence":"additional","affiliation":[{"name":"Faculty of Science, Charles University , , Hlavova 2030 , ,","place":["Praha 2, Czech Republic, 128 43"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5198-8950","authenticated-orcid":true,"given":"Jan","family":"Vesely\u0301","sequence":"additional","affiliation":[{"name":"Faculty of Science, Charles University , , Hlavova 2030 , ,","place":["Praha 2, Czech Republic, 128 43"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"316","published-online":{"date-parts":[[2026,9,17]]},"reference":[{"issue":"5","key":"2026100208064984800_cit1","doi-asserted-by":"publisher","first-page":"34","DOI":"10.1007\/s41061-021-00347-5","article-title":"Pyrrolidine\nin Drug Discovery: A Versatile Scaffold for Novel Biologically Active\nCompounds","volume":"379","author":"Li Petri","year":"2021","journal-title":"Top. 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