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Operating under visible light, this strategy exhibits good substrate generality, particularly for activated aliphatic carboxylic acids and facilitates the late-stage functionalization of complex pharmaceutical scaffolds. The operationally simple photocatalyst can be recycled over seven consecutive cycles while maintaining high catalytic efficacy. Crucially, a continuous-flow, gram-scale synthesis validates its practical scalability. Mechanistic studies confirm a closed-loop photoredox pathway, establishing a versatile platform for C(sp3)\u2013F bond construction.<\/jats:p>","DOI":"10.1021\/acs.joc.6c01769","type":"journal-article","created":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T19:02:20Z","timestamp":1791918140000},"page":"14355-14361","source":"Crossref","is-referenced-by-count":0,"title":["Practical C(sp3)\u2013F Bond Construction via Metal-Free Heterogeneous Photodecarboxylative Fluorination in Continuous Flow"],"prefix":"10.1021","volume":"91","author":[{"ORCID":"https:\/\/orcid.org\/0009-0004-6892-9016","authenticated-orcid":true,"given":"Caiwen","family":"Wan","sequence":"first","affiliation":[{"name":"Chongqing University of Education , , ,","place":["Chongqing, People\u2019s Republic of China, 400067"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ruolan","family":"Leng","sequence":"additional","affiliation":[{"name":"Chongqing University of Education , , ,","place":["Chongqing, People\u2019s Republic of China, 400067"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yingjie","family":"Zhu","sequence":"additional","affiliation":[{"name":"Chongqing University of Education , , ,","place":["Chongqing, People\u2019s Republic of China, 400067"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Changtong","family":"Shao","sequence":"additional","affiliation":[{"name":"Chongqing University of Education , , ,","place":["Chongqing, People\u2019s Republic of China, 400067"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Junwen","family":"Shu","sequence":"additional","affiliation":[{"name":"Chongqing University of Education , , ,","place":["Chongqing, People\u2019s Republic of China, 400067"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhangyi","family":"Ran","sequence":"additional","affiliation":[{"name":"Chongqing University of Education , , ,","place":["Chongqing, People\u2019s Republic of China, 400067"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yexuan","family":"Luo","sequence":"additional","affiliation":[{"name":"Chongqing University of Education , , ,","place":["Chongqing, People\u2019s Republic of China, 400067"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jie","family":"Gao","sequence":"additional","affiliation":[{"name":"Chongqing University of Education , , ,","place":["Chongqing, People\u2019s Republic of China, 400067"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2369-6664","authenticated-orcid":true,"given":"Dingfeng","family":"Yang","sequence":"additional","affiliation":[{"name":"Chongqing University of Technology , , 69 Hongguang Rd, Lijiatuo, Banan District , ,","place":["Chongqing, People\u2019s Republic of China, 400054"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3299-505X","authenticated-orcid":true,"given":"Yuanyuan","family":"Li","sequence":"additional","affiliation":[{"name":"Chongqing University of Education , , ,","place":["Chongqing, People\u2019s Republic of China, 400067"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"316","published-online":{"date-parts":[[2026,10,13]]},"reference":[{"key":"2026103005071770100_cit1","doi-asserted-by":"publisher","first-page":"320","DOI":"10.1039\/B610213C","article-title":"Fluorine in medicinal chemistry","volume":"37","author":"Purser","year":"2008","journal-title":"Chem. 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