{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,30]],"date-time":"2026-10-30T09:50:47Z","timestamp":1793353847839,"version":"4.5.0"},"reference-count":22,"publisher":"American Chemical Society (ACS)","issue":"43","license":[{"start":{"date-parts":[[2026,10,14]],"date-time":"2026-10-14T00:00:00Z","timestamp":1791936000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2026,10,14]],"date-time":"2026-10-14T00:00:00Z","timestamp":1791936000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2026,10,14]],"date-time":"2026-10-14T00:00:00Z","timestamp":1791936000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-045"}],"funder":[{"DOI":"10.13039\/501100004543","name":"China Scholarship Council","doi-asserted-by":"publisher","award":["JXJZHM20220519"],"award-info":[{"award-number":["JXJZHM20220519"]}],"id":[{"id":"10.13039\/501100004543","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026,10,30]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Herein, we report the synthesis of a new class of noncanonical \u03b1-amino acids bearing metal-chelating functionalities through Negishi cross-coupling between iodinated serine- or homoserine-derived substrates and pyridyl or polypyridyl partners. The method provides straightforward access to gram-scale quantities of amino acids bearing a range of nitrogen-based chelating ligands, including pyridine, bipyridine, phenanthroline, and terpyridine motifs, without detectable racemization throughout the reaction sequence.<\/jats:p>","DOI":"10.1021\/acs.joc.6c01777","type":"journal-article","created":{"date-parts":[[2026,10,14]],"date-time":"2026-10-14T18:02:12Z","timestamp":1792000932000},"page":"14704-14709","source":"Crossref","is-referenced-by-count":0,"title":["Synthesis of Enantiopure Metal-Chelating Noncanonical Amino Acids via Negishi Cross-Coupling"],"prefix":"10.1021","volume":"91","author":[{"given":"Jibao","family":"Zhu","sequence":"first","affiliation":[{"name":"Institut de Chimie Mol\u00e9culaire et des Mat\u00e9riaux d\u2019Orsay, UMR 8182 CNRS, Universit\u00e9 Paris-Saclay , B\u00e2timent Henri Moissan , ,","place":["Orsay, France, F-91405"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5399-9469","authenticated-orcid":true,"given":"Cyrille","family":"Kouklovsky","sequence":"additional","affiliation":[{"name":"Institut de Chimie Mol\u00e9culaire et des Mat\u00e9riaux d\u2019Orsay, UMR 8182 CNRS, Universit\u00e9 Paris-Saclay , B\u00e2timent Henri Moissan , ,","place":["Orsay, France, F-91405"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3734-0052","authenticated-orcid":true,"given":"Val\u00e9rie","family":"Alezra","sequence":"additional","affiliation":[{"name":"Institut de Chimie Mol\u00e9culaire et des Mat\u00e9riaux d\u2019Orsay, UMR 8182 CNRS, Universit\u00e9 Paris-Saclay , B\u00e2timent Henri Moissan , ,","place":["Orsay, France, F-91405"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"316","published-online":{"date-parts":[[2026,10,14]]},"reference":[{"issue":"1","key":"2026103005071368800_cit1","doi-asserted-by":"publisher","first-page":"31","DOI":"10.1038\/s41570-021-00339-5","article-title":"De Novo Metalloprotein Design","volume":"6","author":"Chalkley","year":"2022","journal-title":"Nat. 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