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This modular protocol enables efficient construction of structurally diverse 1,4-benzoxazepine derivatives with moderate to excellent yields, featuring broad substrate generality and remarkable functional group compatibility. The potential synthetic utility of this protocol is demonstrated by late-stage modification of natural product-derived alcohols (1-undecanol, Majantol, and citronellol) in 85\u201397% yield and scale-up reaction.<\/jats:p>","DOI":"10.1021\/acs.joc.6c01890","type":"journal-article","created":{"date-parts":[[2026,9,21]],"date-time":"2026-09-21T14:04:09Z","timestamp":1789999449000},"page":"13314-13321","source":"Crossref","is-referenced-by-count":0,"title":["Synthesis of 1,4-Benzoxazepines\nvia [4 + 3] Annulation\nof\n                    <i>ortho<\/i>\n                    -Vinylphenols and Azaoxyallyl Cations"],"prefix":"10.1021","volume":"91","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4097-0031","authenticated-orcid":true,"given":"Zhan-Yong","family":"Wang","sequence":"first","affiliation":[{"name":"Xinxiang University , , ,","place":["Xinxiang, China, 453003"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Can","family":"Zhang","sequence":"additional","affiliation":[{"name":"Xinxiang University , , ,","place":["Xinxiang, China, 453003"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiao-Tian","family":"Wang","sequence":"additional","affiliation":[{"name":"Xinxiang University , , ,","place":["Xinxiang, China, 453003"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiao-Jin","family":"Sun","sequence":"additional","affiliation":[{"name":"Xinxiang University , , ,","place":["Xinxiang, China, 453003"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yi-Lin","family":"Wang","sequence":"additional","affiliation":[{"name":"Xinxiang University , , ,","place":["Xinxiang, China, 453003"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xue-Kai","family":"Li","sequence":"additional","affiliation":[{"name":"Henan Zhongjie Pharmaceutical Co., Ltd. , ,","place":["Xinxiang, China, 453003"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rong-Hao","family":"Zhang","sequence":"additional","affiliation":[{"name":"Henan Zhongjie Pharmaceutical Co., Ltd. , ,","place":["Xinxiang, China, 453003"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ran","family":"Xia","sequence":"additional","affiliation":[{"name":"Xinxiang University , , ,","place":["Xinxiang, China, 453003"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5401-2953","authenticated-orcid":true,"given":"Hongxin","family":"Liu","sequence":"additional","affiliation":[{"name":"Wenzhou University , , ,","place":["Wenzhou, China, 325035"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"316","published-online":{"date-parts":[[2026,9,21]]},"reference":[{"key":"2026100208065926400_cit1a","doi-asserted-by":"publisher","first-page":"6816","DOI":"10.1016\/j.bmcl.2013.10.013","article-title":"Amino acids derived benzoxazepines:\nDesign, synthesis and antitumor activity","volume":"23","author":"Dwivedi","year":"2013","journal-title":"Bioorg.\nMed. 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