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The mechanistic study revealed that selective radical addition, cyclization and radical-polar-crossover (RPC) process were involved in this transformation. We next deliverd a preliminary application investigation, and found that 3wj exhibited significant inhibitory effect on B16F10 cells, most showed a significant photophysical property, and some were applied as fluorescent dyes into live-cell imaging.<\/jats:p>","DOI":"10.1021\/acs.joc.6c01943","type":"journal-article","created":{"date-parts":[[2026,10,21]],"date-time":"2026-10-21T23:01:32Z","timestamp":1792623692000},"source":"Crossref","is-referenced-by-count":0,"title":["Photoinduced Selective Cyclization Cascades of Unactivated\n                    <i>N<\/i>\n                    -alkene-Linked Indoles with the Insertion of Sulfur Dioxide and Its Preliminary Application Investigation"],"prefix":"10.1021","author":[{"given":"Jiaqi","family":"Huang","sequence":"first","affiliation":[{"name":"Gannan Medical University , , ,","place":["Ganzhou, China, 341000"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiwei","family":"Li","sequence":"additional","affiliation":[{"name":"China Pharmaceutical University , , ,","place":["Nanjing, China, 211198"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuwei","family":"Zeng","sequence":"additional","affiliation":[{"name":"Gannan Medical University , , ,","place":["Ganzhou, China, 341000"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qichen","family":"Li","sequence":"additional","affiliation":[{"name":"Gannan Medical University , , ,","place":["Ganzhou, China, 341000"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yueyue","family":"Jia","sequence":"additional","affiliation":[{"name":"Gannan Medical University , , ,","place":["Ganzhou, China, 341000"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Feng","family":"Liang","sequence":"additional","affiliation":[{"name":"Gannan Medical University , , ,","place":["Ganzhou, China, 341000"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhenzhen","family":"Hu","sequence":"additional","affiliation":[{"name":"Gannan Medical University , , ,","place":["Ganzhou, China, 341000"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"You","family":"Mao","sequence":"additional","affiliation":[{"name":"Zhejiang PHT Pharmaceutical Co., Ltd , ,","place":["Shaoxing, China, 312369"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1018-4694","authenticated-orcid":true,"given":"Jiangwei","family":"Tian","sequence":"additional","affiliation":[{"name":"China Pharmaceutical University , , ,","place":["Nanjing, China, 211198"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8338-9725","authenticated-orcid":true,"given":"Min","family":"Yang","sequence":"additional","affiliation":[{"name":"Gannan Medical University , , ,","place":["Ganzhou, China, 341000"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"316","published-online":{"date-parts":[[2026,10,22]]},"reference":[{"key":"2026102119012816600_cit1","doi-asserted-by":"publisher","first-page":"487","DOI":"10.1002\/wcms.1261","article-title":"The Baldwin rules: revised and extended","volume":"6","author":"Gilmore","year":"2016","journal-title":"WIREs Comput. 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