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This transition-metal-free protocol employs readily available dioxazolones as isocyanate precursors and proceeds through a cascade sequence involving decarboxylation, Lossen rearrangement, nucleophilic addition, and aza-Michael addition. Through this cascade process, complex polycyclic indole-based scaffolds are efficiently constructed in a single operation. The established methodology features operational simplicity, broad substrate scope, scalability to gram-scale synthesis, and potential for late-stage functionalization.<\/jats:p>","DOI":"10.1021\/acs.joc.6c01979","type":"journal-article","created":{"date-parts":[[2026,10,9]],"date-time":"2026-10-09T15:02:03Z","timestamp":1791558123000},"page":"14556-14562","source":"Crossref","is-referenced-by-count":0,"title":["Synthesis of Pyrroloquinazolinones via Base-Promoted Domino Reaction of 7-Vinylindoles with\n                    <i>In Situ<\/i>\n                    Formed Isocyanates from Dioxazolones"],"prefix":"10.1021","volume":"91","author":[{"given":"Xiaoquan","family":"Qiu","sequence":"first","affiliation":[{"name":"Affiliated Central People\u2019s Hospital, China Three Gorges University , , , ,","place":["Yichang, Hubei, China, 443003"]},{"name":"China Three Gorges University , , , ,","place":["Yichang, Hubei, China, 443002"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yu","family":"Xin","sequence":"additional","affiliation":[{"name":"China Three Gorges University , , , ,","place":["Yichang, Hubei, China, 443002"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jinglei","family":"Wang","sequence":"additional","affiliation":[{"name":"China Three Gorges University , , , ,","place":["Yichang, Hubei, China, 443002"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Haojie","family":"Gao","sequence":"additional","affiliation":[{"name":"China Three Gorges University , , , ,","place":["Yichang, Hubei, China, 443002"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yushuang","family":"Chen","sequence":"additional","affiliation":[{"name":"Chongqing University of Science and Technology , , ,","place":["Chongqing, China, 401331"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4450-8602","authenticated-orcid":true,"given":"Hui","family":"Yao","sequence":"additional","affiliation":[{"name":"China Three Gorges University , , , ,","place":["Yichang, Hubei, China, 443002"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9836-1442","authenticated-orcid":true,"given":"Linxuan","family":"Li","sequence":"additional","affiliation":[{"name":"China Three Gorges University , , , ,","place":["Yichang, Hubei, China, 443002"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6858-5629","authenticated-orcid":true,"given":"Zhong-Yan","family":"Cao","sequence":"additional","affiliation":[{"name":"Henan University , , , ,","place":["Kaifeng, Henan, China, 475004"]},{"name":"Nanjing Forestry University , , , ,","place":["Nanjing, Jiangsu, Jiangsu, China, 210037"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0002-1870-9125","authenticated-orcid":true,"given":"Jinkun","family":"Zhang","sequence":"additional","affiliation":[{"name":"Affiliated Central People\u2019s Hospital, China Three Gorges University , , , ,","place":["Yichang, Hubei, China, 443003"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4483-160X","authenticated-orcid":true,"given":"Nianyu","family":"Huang","sequence":"additional","affiliation":[{"name":"China Three Gorges University , , , ,","place":["Yichang, Hubei, China, 443002"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1690-7611","authenticated-orcid":true,"given":"Nengzhong","family":"Wang","sequence":"additional","affiliation":[{"name":"China Three Gorges University , , , ,","place":["Yichang, Hubei, China, 443002"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"316","published-online":{"date-parts":[[2026,10,9]]},"reference":[{"key":"2026103005072889300_cit1a","doi-asserted-by":"publisher","first-page":"727","DOI":"10.1016\/j.bmcl.2005.10.012","article-title":"A Novel Class of Sodium\/calcium Exchanger Inhibitors: Design, Synthesis, and Structure-Activity Relationships of 4-Phenyl-3-(Piperidin-4-Y1)-3,4-Dihydro-2(1H)-Quinazolinone Derivatives","volume":"16","author":"Hasegawa","year":"2006","journal-title":"Bioorg. 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