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At room temperature, 2-substituted pyridinederivatives are obtained in 59\u201375% yields via [3 + 3] cyclization mediated bythe mixed acids FeCl3 and H2C2O4 in equimolar amounts. In addition, thereaction takes place by using FeCl3 and TBHP via a [3 + 2 + 1] cyclization tosynthesize 3-acyl-substituted pyrido[2,3-d]pyrimidine-2,4-diones. Thisprotocol showcases the unique dual reactivity of enaminones, which act notonly as reaction partners but also as one-carbon (C1) building blocks via C\u2013C bond cleavage and C\u2550C bond cleavage. Thismethod features easily accessible starting materials, mild divergent reaction conditions, and high synthetic efficiency. Based oncontrol experiments and previous reports, we have also proposed a plausible mechanism for this reaction.<\/jats:p>","DOI":"10.1021\/acs.joc.6c01981","type":"journal-article","created":{"date-parts":[[2026,10,20]],"date-time":"2026-10-20T00:01:13Z","timestamp":1792454473000},"page":"14563-14568","source":"Crossref","is-referenced-by-count":0,"title":["Acid-Mediated [3 + 3] or [3 + 2 + 1] Cyclization between Enaminones and 6-Aminouracils to Access 2-Substituted Pyridine Derivatives or 3-Acyl-Substituted Pyrido[2,3-\n                    <i>d<\/i>\n                    ]pyrimidine-2,4-diones"],"prefix":"10.1021","volume":"91","author":[{"given":"Wenhui","family":"Xie","sequence":"first","affiliation":[{"name":"Yichun University , , , ,","place":["Yichun, Jiangxi, China, 336000"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hui","family":"Liang","sequence":"additional","affiliation":[{"name":"Yichun University , , , ,","place":["Yichun, Jiangxi, China, 336000"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhiyong","family":"Zhu","sequence":"additional","affiliation":[{"name":"Yichun University , , , ,","place":["Yichun, Jiangxi, China, 336000"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9051-0167","authenticated-orcid":true,"given":"Changyuan","family":"Zhang","sequence":"additional","affiliation":[{"name":"Yichun University , , , ,","place":["Yichun, Jiangxi, China, 336000"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2820-6137","authenticated-orcid":true,"given":"Leiqing","family":"Fu","sequence":"additional","affiliation":[{"name":"Yichun University , , , ,","place":["Yichun, Jiangxi, China, 336000"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9367-8384","authenticated-orcid":true,"given":"Jie-Ping","family":"Wan","sequence":"additional","affiliation":[{"name":"Nanjing Forestry University , , ,","place":["Nanjing, China, 210037"]},{"name":"Jiangxi Normal University , , , ,","place":["Nanchang, Jiangxi, China, 330022"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"316","published-online":{"date-parts":[[2026,10,19]]},"reference":[{"key":"2026103005080539200_cit1a","doi-asserted-by":"publisher","first-page":"701","DOI":"10.1016\/0223-5234(96)85879-X","article-title":"Molecular Simulation of 5,6-Substituted 1-[(2-Hydroxyethoxy)-methyl]uracils with Anti-HIV-1 Activity","volume":"31","author":"Mager","year":"1996","journal-title":"Eur. 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