{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,23]],"date-time":"2026-10-23T20:41:56Z","timestamp":1792788116043,"version":"4.5.0"},"reference-count":50,"publisher":"American Chemical Society (ACS)","license":[{"start":{"date-parts":[[2026,10,20]],"date-time":"2026-10-20T00:00:00Z","timestamp":1792454400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2026,10,20]],"date-time":"2026-10-20T00:00:00Z","timestamp":1792454400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2026,10,20]],"date-time":"2026-10-20T00:00:00Z","timestamp":1792454400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-045"}],"funder":[{"name":"Syngenta Biosciences Pvt. Ltd."}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Mechanochemistry has emerged as a transformative innovation in chemical synthesis, enabling solvent-free, energy\u2011efficient transformations that align with the principles of green chemistry. Herein, we report a sequential two\u2011step, one\u2011pot ball\u2011milling protocol for the synthesis of 1,3,5\u2011trisubstituted 1,2,4\u2011triazoles, expanding the scope of nitrogen heterocycle chemistry into the mechanochemical domain. N-aroyl and acyl amidines were prepared quantitatively from benzamides, heteroaryl carboxamides, and alkyl carboxamides using 1,1\u2011dimethoxy\u2011N,N\u2011dimethylmethan or ethanamine (DMF\u2011DMA or DMA-DMA), or Bredereck\u2019s reagent (tert\u2011butoxy bis(dimethylamino)methane) under solvent-free milling conditions, followed by condensation with hydrazines in the presence of acetic acid to afford triazoles in good to excellent yields (51\u201391%). The methodology demonstrated broad substrate tolerance, including aryl, heteroaryl, and alkyl derivatives, and was successfully applied to the sustainable synthesis of penipanoid A, a bioactive marine natural product, under mild, solvent\u2011free conditions.<\/jats:p>","DOI":"10.1021\/acs.joc.6c02087","type":"journal-article","created":{"date-parts":[[2026,10,19]],"date-time":"2026-10-19T19:02:28Z","timestamp":1792436548000},"source":"Crossref","is-referenced-by-count":0,"title":["Mechanochemistry\u2011Enabled One\u2011Pot Formation of 1,2,4\u2011Triazoles toward the Sustainable Penipanoid A Synthesis"],"prefix":"10.1021","author":[{"ORCID":"https:\/\/orcid.org\/0009-0004-0402-5923","authenticated-orcid":true,"given":"Sachin Balu","family":"Chavan","sequence":"first","affiliation":[{"name":"Syngenta Biosciences Private Limited , Santa Monica Works, Corlim , ,","place":["Goa, India, 403110"]},{"name":"Goa University , , , ,","place":["Taleigao Plateau, Goa, India, 403206"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dipali","family":"Rao","sequence":"additional","affiliation":[{"name":"Syngenta Biosciences Private Limited , Santa Monica Works, Corlim , ,","place":["Goa, India, 403110"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sushila Dilraj","family":"Joshi","sequence":"additional","affiliation":[{"name":"Syngenta Biosciences Private Limited , Santa Monica Works, Corlim , ,","place":["Goa, India, 403110"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0004-0174-7576","authenticated-orcid":true,"given":"Mangala","family":"Phadte","sequence":"additional","affiliation":[{"name":"Syngenta Biosciences Private Limited , Santa Monica Works, Corlim , ,","place":["Goa, India, 403110"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"316","published-online":{"date-parts":[[2026,10,20]]},"reference":[{"issue":"2","key":"2026102316065179500_cit1","doi-asserted-by":"publisher","first-page":"12","DOI":"10.1515\/ci-2019-0203","article-title":"Ten Chemical Innovations That Will Change Our World: IUPAC Identifies Emerging Technologies in Chemistry with Potential to Make Our Planet More Sustainable","volume":"41","author":"Gomoll\u00f3n-Bel","year":"2019","journal-title":"Chem. 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