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However, such transformations have been largely limited to intermolecular processes and have not been explored on \u03b2-substituted enones. Herein, we report a sequential one-pot dual catalytic approach that merges Cu-catalyzed enantioselective conjugate addition of trialkylaluminum reagents with intramolecular Pd- or Ir-catalyzed allylic alkylation. The methodology enables the synthesis of fused and bridged bicyclic frameworks bearing all-carbon quaternary stereocenters in good yields and high enantioselectivities. In addition, catalyst-controlled stereodivergent synthesis was achieved through the combination of enantiomeric Cu and Ir catalysts, providing selective access to all four stereoisomers of a representative bicyclic product. This work provides a versatile strategy for the synthesis of enantioenriched bicyclic architectures, and its synthetic utility was further demonstrated through a gram-scale synthesis and application to the formal syntheses of (+)-\u03b2-gorgonene and (+)-8,9-epi-\u03b2-gorgonene.<\/jats:p>","DOI":"10.1021\/acs.joc.6c02121","type":"journal-article","created":{"date-parts":[[2026,10,16]],"date-time":"2026-10-16T14:02:08Z","timestamp":1792159328000},"page":"14637-14647","source":"Crossref","is-referenced-by-count":0,"title":["Sequential Dual Catalysis Merging Enantioselective Cu-Catalyzed Conjugate Addition with Intramolecular Pd\/Ir-Catalyzed Allylic Alkylation"],"prefix":"10.1021","volume":"91","author":[{"given":"Sebastian","family":"Str\u00e4hler","sequence":"first","affiliation":[{"name":"Universit\u00e9 Catholique de Louvain , , Place Louis Pasteur 1 bte L4.01.02 , ,","place":["Louvain-la-Neuve, Belgium, 1348"]},{"name":"Vrije Universiteit Amsterdam , , De Boelelaan 1108 , ,","place":["Amsterdam, the Netherlands, 1081 HZ"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anthony","family":"Kromodimedjo","sequence":"additional","affiliation":[{"name":"Vrije Universiteit Amsterdam , , De Boelelaan 1108 , ,","place":["Amsterdam, the Netherlands, 1081 HZ"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rens","family":"Clijnk","sequence":"additional","affiliation":[{"name":"Vrije Universiteit Amsterdam , , De Boelelaan 1108 , ,","place":["Amsterdam, the Netherlands, 1081 HZ"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"\u00dcmeyr","family":"Tasova","sequence":"additional","affiliation":[{"name":"Vrije Universiteit Amsterdam , , De Boelelaan 1108 , ,","place":["Amsterdam, the Netherlands, 1081 HZ"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Remco","family":"Broersen","sequence":"additional","affiliation":[{"name":"Vrije Universiteit Amsterdam , , De Boelelaan 1108 , ,","place":["Amsterdam, the Netherlands, 1081 HZ"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"H. Dani\u00ebl","family":"Preschel","sequence":"additional","affiliation":[{"name":"Vrije Universiteit Amsterdam , , De Boelelaan 1108 , ,","place":["Amsterdam, the Netherlands, 1081 HZ"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4852-6469","authenticated-orcid":true,"given":"Olivier","family":"Riant","sequence":"additional","affiliation":[{"name":"Universit\u00e9 Catholique de Louvain , , Place Louis Pasteur 1 bte L4.01.02 , ,","place":["Louvain-la-Neuve, Belgium, 1348"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1105-3947","authenticated-orcid":true,"given":"Eelco","family":"Ruijter","sequence":"additional","affiliation":[{"name":"Vrije Universiteit Amsterdam , , De Boelelaan 1108 , ,","place":["Amsterdam, the Netherlands, 1081 HZ"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"316","published-online":{"date-parts":[[2026,10,16]]},"reference":[{"key":"2026103005070054100_cit1a","doi-asserted-by":"publisher","first-page":"302","DOI":"10.1039\/b309033g","article-title":"Cooperative Multi-Catalyst Systems for One-Pot Organic Transformations","volume":"33","author":"Lee","year":"2004","journal-title":"Chem. 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