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Although more than 20 kinds of drugs are currently used in clinical practice, there are huge difficulties in the preparation of both active pharmaceutical ingredients and preparations. Prostaglandins directly substituted by aryl groups may overcome these difficulties; however, their preparation remains challenging, and only a few synthetic methods have been reported to date. Herein, we describe a novel FeBr3\/ligand-catalyzed aromatization-C\u2212O bond cleavage process that provides access to aryl-substituted prostaglandin skeletons.<\/jats:p>","DOI":"10.1021\/acs.joc.6c02150","type":"journal-article","created":{"date-parts":[[2026,10,14]],"date-time":"2026-10-14T18:02:10Z","timestamp":1792000930000},"source":"Crossref","is-referenced-by-count":0,"title":["FeBr3-Catalyzed Aromatization-C\u2013O Bond Cleavage Process for Construction of Aryl-Substituted Prostaglandin Skeleton"],"prefix":"10.1021","author":[{"given":"Nai-Xuan","family":"Liu","sequence":"first","affiliation":[{"name":"Fudan University , , ,","place":["Shanghai, China, 201203"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jian-Ting","family":"Sun","sequence":"additional","affiliation":[{"name":"Fudan University , , ,","place":["Shanghai, China, 201203"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rui-Jun","family":"Ma","sequence":"additional","affiliation":[{"name":"Fudan University , , ,","place":["Shanghai, China, 201203"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yu-Ying","family":"Zhang","sequence":"additional","affiliation":[{"name":"Fudan University , , ,","place":["Shanghai, China, 201203"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jing-Bo","family":"Zhou","sequence":"additional","affiliation":[{"name":"Fudan University , , ,","place":["Shanghai, China, 201203"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1488-7311","authenticated-orcid":true,"given":"Jian-Liang","family":"Ye","sequence":"additional","affiliation":[{"name":"Xiamen University , , , ,","place":["Xiamen, Fujian, China, 361005"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3470-6741","authenticated-orcid":true,"given":"Bang-Guo","family":"Wei","sequence":"additional","affiliation":[{"name":"Fudan University , , ,","place":["Shanghai, China, 201203"]},{"name":"Quzhou Fudan Institute , , ,","place":["Quzhou, Zhejiang Province, China, 324000"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"316","published-online":{"date-parts":[[2026,10,15]]},"reference":[{"key":"2026101414020410100_cit1a","doi-asserted-by":"publisher","first-page":"268","DOI":"10.3181\/00379727-28-5265","article-title":"Biochemical studies of human semen. 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