{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,12]],"date-time":"2026-09-12T20:45:06Z","timestamp":1789245906003,"version":"build-2803163510"},"reference-count":23,"publisher":"American Chemical Society (ACS)","issue":"8","license":[{"start":{"date-parts":[[2019,1,2]],"date-time":"2019-01-02T00:00:00Z","timestamp":1546387200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2019,1,2]],"date-time":"2019-01-02T00:00:00Z","timestamp":1546387200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2019,1,2]],"date-time":"2019-01-02T00:00:00Z","timestamp":1546387200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-045"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J. Org. Chem."],"published-print":{"date-parts":[[2019,4,19]]},"DOI":"10.1021\/acs.joc.8b02876","type":"journal-article","created":{"date-parts":[[2019,1,2]],"date-time":"2019-01-02T23:57:31Z","timestamp":1546473451000},"page":"4830-4836","source":"Crossref","is-referenced-by-count":14,"title":["An Alternative Focus for Route Design for the Synthesis of Antibody\u2013Drug Conjugate Payloads"],"prefix":"10.1021","volume":"84","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2936-0515","authenticated-orcid":true,"given":"Arnaud C.","family":"Tiberghien","sequence":"first","affiliation":[{"name":"Spirogen, QMB Innovation Centre, 42 New Road, E1 2AX London, United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Philip W.","family":"Howard","sequence":"additional","affiliation":[{"name":"Spirogen, QMB Innovation Centre, 42 New Road, E1 2AX London, United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2869-5855","authenticated-orcid":true,"given":"William R. F.","family":"Goundry","sequence":"additional","affiliation":[{"name":"Early Chemical Development, Pharmaceutical Sciences, IMED Biotech Unit, AstraZeneca, Macclesfield, United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marc","family":"McCormick","sequence":"additional","affiliation":[{"name":"Early Chemical Development, Pharmaceutical Sciences, IMED Biotech Unit, AstraZeneca, Macclesfield, United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4758-3181","authenticated-orcid":true,"given":"Jeremy S.","family":"Parker","sequence":"additional","affiliation":[{"name":"Early Chemical Development, Pharmaceutical Sciences, IMED Biotech Unit, AstraZeneca, Macclesfield, United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"316","published-online":{"date-parts":[[2019,1,2]]},"reference":[{"key":"ref1\/cit1a","doi-asserted-by":"publisher","DOI":"10.1038\/nrd.2016.268"},{"key":"ref1\/cit1b","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejmech.2017.08.049"},{"key":"ref2\/cit2","doi-asserted-by":"publisher","DOI":"10.1038\/nbt.2289"},{"key":"ref3\/cit3","doi-asserted-by":"publisher","DOI":"10.1021\/jm500766w"},{"key":"ref4\/cit4","doi-asserted-by":"publisher","DOI":"10.1021\/mp500762u"},{"key":"ref5\/cit5","doi-asserted-by":"publisher","DOI":"10.1021\/ja00256a070"},{"key":"ref6\/cit6","doi-asserted-by":"publisher","DOI":"10.1208\/s12248-012-9386-x"},{"key":"ref7\/cit7","doi-asserted-by":"publisher","DOI":"10.1021\/ja00759a054"},{"key":"ref8\/cit8","doi-asserted-by":"publisher","DOI":"10.1002\/anie.201510610"},{"key":"ref9\/cit9","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-018-28533-4"},{"key":"ref10\/cit10","doi-asserted-by":"publisher","DOI":"10.1007\/s40268-018-0247-7"},{"key":"ref11\/cit11","first-page":"2543","volume":"130","author":"O\u2019Connor O. A.","year":"2017","journal-title":"Blood"},{"key":"ref12\/cit12","doi-asserted-by":"publisher","DOI":"10.1021\/acsmedchemlett.6b00062"},{"key":"ref13\/cit13","doi-asserted-by":"publisher","DOI":"10.1021\/acs.oprd.8b00205"},{"key":"ref14\/cit14","doi-asserted-by":"publisher","DOI":"10.1021\/acs.bioconjchem.7b00476"},{"key":"ref15\/cit15","unstructured":"Howard, P. W. Pyrrolobenzodiazepines And Conjugates Thereof. WO 2014\/057074 A1, 2014."},{"key":"ref16\/cit16","doi-asserted-by":"publisher","DOI":"10.1055\/s-1981-29377"},{"key":"ref17\/cit17","doi-asserted-by":"publisher","DOI":"10.1021\/ja00902a036"},{"key":"ref18\/cit18","doi-asserted-by":"publisher","DOI":"10.1055\/s-2008-1078445"},{"key":"ref19\/cit19","doi-asserted-by":"publisher","DOI":"10.1021\/jo00170a070"},{"key":"ref20\/cit20","doi-asserted-by":"publisher","DOI":"10.1021\/ja00997a067"},{"key":"ref21\/cit21","doi-asserted-by":"publisher","DOI":"10.1021\/jo971046m"},{"key":"ref22\/cit22","doi-asserted-by":"publisher","DOI":"10.1021\/ja206230h"}],"container-title":["The Journal of Organic Chemistry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/pubs.acs.org\/doi\/pdf\/10.1021\/acs.joc.8b02876","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,4,23]],"date-time":"2023-04-23T11:19:33Z","timestamp":1682248773000},"score":1,"resource":{"primary":{"URL":"https:\/\/pubs.acs.org\/doi\/10.1021\/acs.joc.8b02876"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,1,2]]},"references-count":23,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2019,4,19]]}},"alternative-id":["10.1021\/acs.joc.8b02876"],"URL":"https:\/\/doi.org\/10.1021\/acs.joc.8b02876","relation":{},"ISSN":["0022-3263","1520-6904"],"issn-type":[{"value":"0022-3263","type":"print"},{"value":"1520-6904","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,1,2]]}}}