{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,15]],"date-time":"2026-10-15T00:52:25Z","timestamp":1792025545892,"version":"4.4.0"},"reference-count":76,"publisher":"American Chemical Society (ACS)","issue":"25","license":[{"start":{"date-parts":[[2023,6,16]],"date-time":"2023-06-16T00:00:00Z","timestamp":1686873600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2023,6,16]],"date-time":"2023-06-16T00:00:00Z","timestamp":1686873600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2023,6,16]],"date-time":"2023-06-16T00:00:00Z","timestamp":1686873600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-045"}],"funder":[{"DOI":"10.13039\/501100001869","name":"Academia Sinica","doi-asserted-by":"publisher","award":["AS- IA-107-L03"],"award-info":[{"award-number":["AS- IA-107-L03"]}],"id":[{"id":"10.13039\/501100001869","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004663","name":"Ministry of Science and Technology, Taiwan","doi-asserted-by":"publisher","award":["MOST-105-2113-M-001-018-MY5"],"award-info":[{"award-number":["MOST-105-2113-M-001-018-MY5"]}],"id":[{"id":"10.13039\/501100004663","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J. Phys. Chem. B"],"published-print":{"date-parts":[[2023,6,29]]},"DOI":"10.1021\/acs.jpcb.3c01637","type":"journal-article","created":{"date-parts":[[2023,6,16]],"date-time":"2023-06-16T21:16:15Z","timestamp":1686950175000},"page":"5588-5600","source":"Crossref","is-referenced-by-count":8,"title":["Protein Ca<sup>2+<\/sup>-Sites Prone to Sr<sup>2+<\/sup> Substitution: Implications for Strontium Therapy"],"prefix":"10.1021","volume":"127","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3407-4097","authenticated-orcid":true,"given":"Karine","family":"Mazmanian","sequence":"first","affiliation":[{"name":"Institute of Biomedical Sciences, Academia Sinica, Taipei 115, Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C\u00e9dric","family":"Grauffel","sequence":"additional","affiliation":[{"name":"Institute of Biomedical Sciences, Academia Sinica, Taipei 115, Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8186-2141","authenticated-orcid":true,"given":"Todor","family":"Dudev","sequence":"additional","affiliation":[{"name":"Faculty of Chemistry and Pharmacy, Sofia University, Sofia 1164, Bulgaria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9077-7769","authenticated-orcid":true,"given":"Carmay","family":"Lim","sequence":"additional","affiliation":[{"name":"Institute of Biomedical Sciences, Academia Sinica, Taipei 115, Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"316","published-online":{"date-parts":[[2023,6,16]]},"reference":[{"key":"ref1\/cit1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bonr.2020.100273"},{"key":"ref2\/cit2","doi-asserted-by":"publisher","DOI":"10.1016\/j.bone.2004.04.026"},{"key":"ref3\/cit3","doi-asserted-by":"publisher","DOI":"10.1080\/07391102.2004.10507001"},{"key":"ref4\/cit4","doi-asserted-by":"publisher","DOI":"10.1007\/s002590000315"},{"key":"ref5\/cit5","doi-asserted-by":"publisher","DOI":"10.1359\/jbmr.1999.14.5.661"},{"key":"ref6\/cit6","doi-asserted-by":"publisher","DOI":"10.1007\/s002230010055"},{"key":"ref7\/cit7","doi-asserted-by":"publisher","DOI":"10.1007\/s00198-015-3203-1"},{"key":"ref8\/cit8","doi-asserted-by":"publisher","DOI":"10.7554\/eLife.13662"},{"key":"ref9\/cit9","doi-asserted-by":"publisher","DOI":"10.1021\/jp054975n"},{"key":"ref10\/cit10","doi-asserted-by":"publisher","DOI":"10.1021\/jp0638033"},{"key":"ref11\/cit11","doi-asserted-by":"publisher","DOI":"10.1007\/s00198-002-1343-6"},{"key":"ref12\/cit12","doi-asserted-by":"publisher","DOI":"10.1111\/bph.14344"},{"key":"ref13\/cit13","doi-asserted-by":"crossref","first-page":"2133","DOI":"10.1007\/978-1-4614-1533-6_175","volume-title":"Encyclopedia of metalloproteins","author":"Uversky V. N.","year":"2013"},{"key":"ref14\/cit14","doi-asserted-by":"publisher","DOI":"10.3390\/biom11081158"},{"key":"ref15\/cit15","doi-asserted-by":"publisher","DOI":"10.1107\/S0907444902003451"},{"key":"ref16\/cit16","doi-asserted-by":"publisher","DOI":"10.1021\/jp304925a"},{"key":"ref17\/cit17","doi-asserted-by":"publisher","DOI":"10.1021\/ja0429115"},{"key":"ref18\/cit18","doi-asserted-by":"publisher","DOI":"10.1002\/jcc.21048"},{"key":"ref19\/cit19","doi-asserted-by":"publisher","DOI":"10.1021\/acs.jpcb.6b01054"},{"key":"ref20\/cit20","doi-asserted-by":"publisher","DOI":"10.1039\/C9CP00142E"},{"key":"ref21\/cit21","doi-asserted-by":"publisher","DOI":"10.1021\/ja0209722"},{"key":"ref22\/cit22","unstructured":"Dennington, R.; Keith, T.; Millam, J. Gaussview, version 5; Semichem Inc.: Shawnee Mission, KS, 2009."},{"key":"ref23\/cit23","doi-asserted-by":"publisher","DOI":"10.1107\/S0108768102003890"},{"key":"ref24\/cit24","doi-asserted-by":"publisher","DOI":"10.1063\/1.3382344"},{"key":"ref25\/cit25","doi-asserted-by":"publisher","DOI":"10.1039\/C7CP04913G"},{"key":"ref26\/cit26","doi-asserted-by":"publisher","DOI":"10.1021\/acs.jpcc.7b09062"},{"key":"ref27\/cit27","doi-asserted-by":"publisher","DOI":"10.1016\/j.trechm.2020.02.005"},{"key":"ref28\/cit28","doi-asserted-by":"publisher","DOI":"10.1063\/1.448799"},{"key":"ref29\/cit29","doi-asserted-by":"publisher","DOI":"10.1080\/00268979100102941"},{"key":"ref30\/cit30","doi-asserted-by":"publisher","DOI":"10.1016\/S0065-3276(08)60416-5"},{"key":"ref31\/cit31","doi-asserted-by":"publisher","DOI":"10.1351\/pac200375010071"},{"key":"ref32\/cit32","doi-asserted-by":"publisher","DOI":"10.1351\/pac200577081445"},{"key":"ref33\/cit33","doi-asserted-by":"publisher","DOI":"10.1021\/acs.jpca.6b12147"},{"key":"ref34\/cit34","doi-asserted-by":"crossref","DOI":"10.1007\/978-1-4615-6764-6","volume-title":"Critical Stability Constants","volume":"2","author":"Smith R. M.","year":"1989"},{"key":"ref35\/cit35","doi-asserted-by":"publisher","DOI":"10.3390\/biom11111576"},{"key":"ref36\/cit36","doi-asserted-by":"publisher","DOI":"10.1002\/pro.3289"},{"key":"ref37\/cit37","doi-asserted-by":"publisher","DOI":"10.1107\/S0567739476001551"},{"key":"ref38\/cit38","doi-asserted-by":"publisher","DOI":"10.1021\/jp0716583"},{"key":"ref39\/cit39","doi-asserted-by":"publisher","DOI":"10.1021\/acs.jctc.0c00043"},{"key":"ref40\/cit40","doi-asserted-by":"publisher","DOI":"10.1107\/S1399004714027734"},{"key":"ref41\/cit41","doi-asserted-by":"publisher","DOI":"10.1016\/j.pharmthera.2012.07.009"},{"key":"ref42\/cit42","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M505186200"},{"key":"ref43\/cit43","doi-asserted-by":"publisher","DOI":"10.1111\/j.1582-4934.2008.00673.x"},{"key":"ref44\/cit44","doi-asserted-by":"publisher","DOI":"10.1359\/jbmr.040114"},{"key":"ref45\/cit45","doi-asserted-by":"publisher","DOI":"10.1159\/000327950"},{"key":"ref46\/cit46","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gkh430"},{"key":"ref47\/cit47","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa022436"},{"key":"ref48\/cit48","volume-title":"Clinical Methods: The History, Physical, and Laboratory Examinations","author":"Goldstein D. A.","year":"1990"},{"key":"ref49\/cit49","first-page":"703","volume":"125","author":"Skoryna S. C.","year":"1981","journal-title":"Can. Med. Assoc. J."},{"key":"ref50\/cit50","doi-asserted-by":"publisher","DOI":"10.1089\/ten.tea.2011.0059"},{"key":"ref51\/cit51","doi-asserted-by":"publisher","DOI":"10.1110\/ps.062123806"},{"key":"ref52\/cit52","doi-asserted-by":"publisher","DOI":"10.1016\/j.bone.2011.06.005"},{"key":"ref53\/cit53","doi-asserted-by":"publisher","DOI":"10.1002\/jbmr.326"},{"key":"ref54\/cit54","doi-asserted-by":"publisher","DOI":"10.1038\/nrendo.2013.4"},{"key":"ref55\/cit55","doi-asserted-by":"publisher","DOI":"10.3892\/etm.2018.6356"},{"key":"ref56\/cit56","doi-asserted-by":"publisher","DOI":"10.1126\/scitranslmed.aaw6143"},{"key":"ref57\/cit57","doi-asserted-by":"publisher","DOI":"10.1002\/chem.201805361"},{"key":"ref58\/cit58","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbamcr.2009.08.006"},{"key":"ref59\/cit59","doi-asserted-by":"publisher","DOI":"10.1021\/cr9804543"},{"key":"ref60\/cit60","doi-asserted-by":"publisher","DOI":"10.1126\/scitranslmed.aaw6143"},{"key":"ref61\/cit61","doi-asserted-by":"publisher","DOI":"10.1016\/j.chembiol.2014.01.008"},{"key":"ref62\/cit62","doi-asserted-by":"publisher","DOI":"10.1038\/cddis.2011.71"},{"key":"ref63\/cit63","doi-asserted-by":"publisher","DOI":"10.1007\/s11914-019-00520-2"},{"key":"ref64\/cit64","doi-asserted-by":"publisher","DOI":"10.1126\/science.1064535"},{"key":"ref65\/cit65","doi-asserted-by":"publisher","DOI":"10.1016\/j.bone.2007.08.034"},{"key":"ref66\/cit66","first-page":"1006","volume":"1","author":"El-Azreqand M. A.","year":"2014","journal-title":"Austin J. Clin. Immunol."},{"key":"ref67\/cit67","doi-asserted-by":"publisher","DOI":"10.1111\/jcmm.15052"},{"key":"ref68\/cit68","doi-asserted-by":"publisher","DOI":"10.4161\/cam.18702"},{"key":"ref69\/cit69","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M112.354365"},{"key":"ref70\/cit70","doi-asserted-by":"publisher","DOI":"10.1007\/978-94-017-9153-3_1"},{"key":"ref71\/cit71","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1097-4652(199809)176:3<634::AID-JCP20>3.0.CO;2-Y"},{"key":"ref72\/cit72","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M111.265454"},{"key":"ref73\/cit73","doi-asserted-by":"publisher","DOI":"10.3389\/fphys.2016.00190"},{"key":"ref74\/cit74","doi-asserted-by":"publisher","DOI":"10.1021\/acs.biochem.7b00188"},{"key":"ref75\/cit75","doi-asserted-by":"publisher","DOI":"10.1210\/endo.138.8.5296"},{"key":"ref76\/cit76","doi-asserted-by":"publisher","DOI":"10.1016\/j.ceca.2004.01.023"}],"container-title":["The Journal of Physical Chemistry B"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/pubs.acs.org\/doi\/pdf\/10.1021\/acs.jpcb.3c01637","content-type":"application\/pdf","content-version":"vor","intended-application":"unspecified"},{"URL":"https:\/\/pubs.acs.org\/doi\/pdf\/10.1021\/acs.jpcb.3c01637","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,6,29]],"date-time":"2023-06-29T08:13:22Z","timestamp":1688026402000},"score":1,"resource":{"primary":{"URL":"https:\/\/pubs.acs.org\/doi\/10.1021\/acs.jpcb.3c01637"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,6,16]]},"references-count":76,"journal-issue":{"issue":"25","published-print":{"date-parts":[[2023,6,29]]}},"alternative-id":["10.1021\/acs.jpcb.3c01637"],"URL":"https:\/\/doi.org\/10.1021\/acs.jpcb.3c01637","relation":{},"ISSN":["1520-6106","1520-5207"],"issn-type":[{"value":"1520-6106","type":"print"},{"value":"1520-5207","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,6,16]]}}}