{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T20:51:36Z","timestamp":1786999896213,"version":"build-2736575974"},"reference-count":74,"publisher":"American Chemical Society (ACS)","issue":"8","license":[{"start":{"date-parts":[[2025,2,14]],"date-time":"2025-02-14T00:00:00Z","timestamp":1739491200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2025,2,14]],"date-time":"2025-02-14T00:00:00Z","timestamp":1739491200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2025,2,14]],"date-time":"2025-02-14T00:00:00Z","timestamp":1739491200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-045"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J. Phys. Chem. B"],"published-print":{"date-parts":[[2025,2,27]]},"DOI":"10.1021\/acs.jpcb.4c07977","type":"journal-article","created":{"date-parts":[[2025,2,14]],"date-time":"2025-02-14T09:15:47Z","timestamp":1739524547000},"page":"2201-2214","source":"Crossref","is-referenced-by-count":3,"title":["Mechanistic Insights into the Inhibitory and Destabilizing Effects of K353 Acetylation on Tau Peptides and Protofibrils"],"prefix":"10.1021","volume":"129","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2006-1022","authenticated-orcid":true,"given":"Jiaxing","family":"Tang","sequence":"first","affiliation":[{"name":"School of Physical Education, Xiangnan University, 889 Chenzhou Avenue, Chenzhou 423000, Hunan, People\u2019s Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Feng","family":"Wang","sequence":"additional","affiliation":[{"name":"School of Physical Education, Xiangnan University, 889 Chenzhou Avenue, Chenzhou 423000, Hunan, People\u2019s Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7606-1094","authenticated-orcid":true,"given":"Zhengdong","family":"Xu","sequence":"additional","affiliation":[{"name":"Department of Physical Education, Shanghai University of Engineering Science, 333 Long Teng Road, Shanghai 201620, People\u2019s Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5699-5869","authenticated-orcid":true,"given":"Yu","family":"Zou","sequence":"additional","affiliation":[{"name":"Department of Sport and Exercise Science, College of Education, Zhejiang University, 866 Yuhangtang Road, Hangzhou 310007, Zhejiang, People\u2019s Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8885-1066","authenticated-orcid":true,"given":"Qingwen","family":"Zhang","sequence":"additional","affiliation":[{"name":"School of Physical Education, Shanghai University of Sport, 399 Changhai Road, Shanghai 200438, People\u2019s Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"316","published-online":{"date-parts":[[2025,2,14]]},"reference":[{"key":"ref1\/cit1","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/aww021"},{"key":"ref2\/cit2","doi-asserted-by":"publisher","DOI":"10.1038\/s41586-021-03911-7"},{"key":"ref3\/cit3","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-023-39328-1"},{"key":"ref4\/cit4","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(20)32205-4"},{"key":"ref5\/cit5","unstructured":"Gauthier, S. W. C.; Servaes, S.; Morais, J. A.; Rosa-Neto, P. World Alzheimer Report 2022: Life After Diagnosis: Navigating Treatment, Care and Support, 2022."},{"key":"ref6\/cit6","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2020.10.029"},{"key":"ref7\/cit7","doi-asserted-by":"publisher","DOI":"10.1111\/bpa.12757"},{"key":"ref8\/cit8","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2017.8334"},{"key":"ref9\/cit9","doi-asserted-by":"publisher","DOI":"10.1002\/ana.25611"},{"key":"ref10\/cit10","doi-asserted-by":"publisher","DOI":"10.1001\/jama.1928.02700150029009"},{"key":"ref11\/cit11","doi-asserted-by":"publisher","DOI":"10.1186\/2051-5960-2-24"},{"key":"ref12\/cit12","doi-asserted-by":"publisher","DOI":"10.1001\/jamaneurol.2023.2907"},{"key":"ref13\/cit13","doi-asserted-by":"publisher","DOI":"10.1007\/s00401-021-02301-7"},{"key":"ref14\/cit14","doi-asserted-by":"publisher","DOI":"10.3233\/JAD-160912"},{"key":"ref15\/cit15","doi-asserted-by":"publisher","DOI":"10.1126\/science.1213151"},{"key":"ref16\/cit16","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.3192-13.2014"},{"key":"ref17\/cit17","doi-asserted-by":"publisher","DOI":"10.1038\/nature23002"},{"key":"ref18\/cit18","doi-asserted-by":"publisher","DOI":"10.1038\/s41586-019-1026-5"},{"key":"ref19\/cit19","doi-asserted-by":"publisher","DOI":"10.1038\/s41586-018-0454-y"},{"key":"ref20\/cit20","doi-asserted-by":"publisher","DOI":"10.1038\/s41586-020-2043-0"},{"key":"ref21\/cit21","doi-asserted-by":"publisher","DOI":"10.3389\/fneur.2020.595532"},{"key":"ref22\/cit22","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuron.2010.08.044"},{"key":"ref23\/cit23","doi-asserted-by":"publisher","DOI":"10.3390\/ijms24098286"},{"key":"ref24\/cit24","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-021-96627-7"},{"key":"ref25\/cit25","doi-asserted-by":"publisher","DOI":"10.1093\/hmg\/ddt402"},{"key":"ref26\/cit26","doi-asserted-by":"publisher","DOI":"10.1016\/j.jbc.2021.101442"},{"key":"ref27\/cit27","doi-asserted-by":"publisher","DOI":"10.1021\/acschemneuro.1c00084"},{"key":"ref28\/cit28","doi-asserted-by":"publisher","DOI":"10.1021\/acschemneuro.2c00611"},{"key":"ref29\/cit29","doi-asserted-by":"publisher","DOI":"10.1021\/acs.jpcb.9b11720"},{"key":"ref30\/cit30","doi-asserted-by":"publisher","DOI":"10.1016\/j.mcn.2022.103707"},{"key":"ref31\/cit31","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbagen.2018.07.030"},{"key":"ref32\/cit32","doi-asserted-by":"publisher","DOI":"10.1021\/acs.jpcb.2c07568"},{"key":"ref33\/cit33","doi-asserted-by":"publisher","DOI":"10.3389\/fmolb.2021.801577"},{"key":"ref34\/cit34","doi-asserted-by":"publisher","DOI":"10.1021\/acs.jcim.3c01929"},{"key":"ref35\/cit35","doi-asserted-by":"publisher","DOI":"10.1002\/jcc.20945"},{"key":"ref36\/cit36","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1096-987X(199709)18:123.0.CO;2-H"},{"key":"ref37\/cit37","doi-asserted-by":"publisher","DOI":"10.1002\/jcc.540130805"},{"key":"ref38\/cit38","doi-asserted-by":"publisher","DOI":"10.1063\/1.464397"},{"key":"ref39\/cit39","doi-asserted-by":"publisher","DOI":"10.1016\/S0006-3495(03)75094-2"},{"key":"ref40\/cit40","doi-asserted-by":"publisher","DOI":"10.1021\/bi0486381"},{"key":"ref41\/cit41","doi-asserted-by":"publisher","DOI":"10.1063\/1.2408420"},{"key":"ref42\/cit42","doi-asserted-by":"publisher","DOI":"10.1063\/1.328693"},{"key":"ref43\/cit43","doi-asserted-by":"publisher","DOI":"10.1002\/bip.360221211"},{"key":"ref44\/cit44","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijbiomac.2023.128467"},{"key":"ref45\/cit45","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbagen.2013.09.012"},{"key":"ref46\/cit46","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1521-3773(19990115)38:1\/23.0.CO;2-M"},{"key":"ref47\/cit47","doi-asserted-by":"publisher","DOI":"10.1021\/acs.jpcb.0c11132"},{"key":"ref48\/cit48","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijbiomac.2022.08.088"},{"key":"ref49\/cit49","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-2836(83)80079-5"},{"key":"ref50\/cit50","doi-asserted-by":"publisher","DOI":"10.1006\/jmbi.1995.0653"},{"key":"ref51\/cit51","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M111.237974"},{"key":"ref52\/cit52","doi-asserted-by":"publisher","DOI":"10.1016\/j.saa.2020.119296"},{"key":"ref53\/cit53","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijbiomac.2023.128900"},{"key":"ref54\/cit54","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbrc.2006.02.185"},{"key":"ref55\/cit55","doi-asserted-by":"publisher","DOI":"10.1021\/acs.jcim.1c00217"},{"key":"ref56\/cit56","doi-asserted-by":"publisher","DOI":"10.1021\/acs.jcim.3c01929"},{"key":"ref57\/cit57","doi-asserted-by":"publisher","DOI":"10.1021\/acschemneuro.0c00598"},{"key":"ref58\/cit58","doi-asserted-by":"publisher","DOI":"10.1039\/D3CP05427F"},{"key":"ref59\/cit59","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbapap.2016.06.007"},{"key":"ref60\/cit60","doi-asserted-by":"publisher","DOI":"10.1186\/1750-1326-6-39"},{"key":"ref61\/cit61","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.5245-10.2011"},{"key":"ref62\/cit62","doi-asserted-by":"publisher","DOI":"10.1126\/science.1079469"},{"key":"ref63\/cit63","doi-asserted-by":"publisher","DOI":"10.1096\/fj.11-199851"},{"key":"ref64\/cit64","doi-asserted-by":"publisher","DOI":"10.1021\/acschemneuro.9b00578"},{"key":"ref65\/cit65","doi-asserted-by":"publisher","DOI":"10.1039\/D3CP01039B"},{"key":"ref66\/cit66","doi-asserted-by":"publisher","DOI":"10.1039\/D2CP02353A"},{"key":"ref67\/cit67","doi-asserted-by":"publisher","DOI":"10.1021\/acschemneuro.3c00103"},{"key":"ref68\/cit68","doi-asserted-by":"publisher","DOI":"10.1021\/acschemneuro.2c00688"},{"key":"ref69\/cit69","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijbiomac.2023.127002"},{"key":"ref70\/cit70","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijbiomac.2016.06.052"},{"key":"ref71\/cit71","doi-asserted-by":"publisher","DOI":"10.3389\/fnagi.2017.00083"},{"key":"ref72\/cit72","doi-asserted-by":"publisher","DOI":"10.3390\/life11010028"},{"key":"ref73\/cit73","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M410984200"},{"key":"ref74\/cit74","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M408714200"}],"container-title":["The Journal of Physical Chemistry B"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/pubs.acs.org\/doi\/pdf\/10.1021\/acs.jpcb.4c07977","content-type":"application\/pdf","content-version":"vor","intended-application":"unspecified"},{"URL":"https:\/\/pubs.acs.org\/doi\/pdf\/10.1021\/acs.jpcb.4c07977","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,2,27]],"date-time":"2025-02-27T04:39:47Z","timestamp":1740631187000},"score":1,"resource":{"primary":{"URL":"https:\/\/pubs.acs.org\/doi\/10.1021\/acs.jpcb.4c07977"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,2,14]]},"references-count":74,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2025,2,27]]}},"alternative-id":["10.1021\/acs.jpcb.4c07977"],"URL":"https:\/\/doi.org\/10.1021\/acs.jpcb.4c07977","relation":{},"ISSN":["1520-6106","1520-5207"],"issn-type":[{"value":"1520-6106","type":"print"},{"value":"1520-5207","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,2,14]]}}}