{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,11]],"date-time":"2026-06-11T08:58:25Z","timestamp":1781168305263,"version":"3.54.1"},"reference-count":56,"publisher":"American Chemical Society (ACS)","issue":"23","license":[{"start":{"date-parts":[[2026,5,28]],"date-time":"2026-05-28T00:00:00Z","timestamp":1779926400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2026,5,28]],"date-time":"2026-05-28T00:00:00Z","timestamp":1779926400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2026,5,28]],"date-time":"2026-05-28T00:00:00Z","timestamp":1779926400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-045"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J. Phys. Chem. B"],"published-print":{"date-parts":[[2026,6,11]]},"DOI":"10.1021\/acs.jpcb.6c00859","type":"journal-article","created":{"date-parts":[[2026,5,28]],"date-time":"2026-05-28T17:58:51Z","timestamp":1779991131000},"page":"5851-5862","source":"Crossref","is-referenced-by-count":0,"title":["Early \u03b1-Synuclein Heterodimerization Kinetics Predict Parkinson\u2019s Disease Onset"],"prefix":"10.1021","volume":"130","author":[{"given":"Sachin","family":"Chaudhary","sequence":"first","affiliation":[{"name":"Department of Chemistry","place":["Pune, India"]},{"name":"Indian Institute of Science Education and Research","place":["Pune, India"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1587-681X","authenticated-orcid":true,"given":"Vaishnavi","family":"Tammara","sequence":"additional","affiliation":[{"name":"Physical and Materials Chemistry Division, CSIR-National Chemical Laboratory, Dr. Homi Bhabha Road, Pune, Maharashtra 411008, India"},{"name":"Academy of Scientific and Innovative Research (AcSIR)","place":["Ghaziabad, India"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bhargavi","family":"Choudhary","sequence":"additional","affiliation":[{"name":"Department of Biotechnology","place":["Pune, India"]},{"name":"Savitribai Phule Pune University","place":["Pune, India"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4994-0469","authenticated-orcid":true,"given":"Atanu","family":"Das","sequence":"additional","affiliation":[{"name":"Physical and Materials Chemistry Division, CSIR-National Chemical Laboratory, Dr. Homi Bhabha Road, Pune, Maharashtra 411008, India"},{"name":"Academy of Scientific and Innovative Research (AcSIR)","place":["Ghaziabad, India"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"316","published-online":{"date-parts":[[2026,5,28]]},"reference":[{"key":"ref1\/cit1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev-biochem-061516-045115"},{"key":"ref2\/cit2","doi-asserted-by":"publisher","DOI":"10.1038\/nrm3810"},{"key":"ref3\/cit3","doi-asserted-by":"publisher","DOI":"10.1038\/s41580-019-0101-y"},{"key":"ref4\/cit4","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.biochem.75.101304.123901"},{"key":"ref5\/cit5","doi-asserted-by":"publisher","DOI":"10.1021\/acs.chemrev.0c01122"},{"key":"ref6\/cit6","doi-asserted-by":"publisher","DOI":"10.1146\/annurev-physchem-040513-103738"},{"key":"ref7\/cit7","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2012.02.022"},{"key":"ref8\/cit8","doi-asserted-by":"publisher","DOI":"10.1016\/j.jmb.2012.01.006"},{"key":"ref9\/cit9","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pbio.0060170"},{"key":"ref10\/cit10","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0501957102"},{"key":"ref11\/cit11","doi-asserted-by":"publisher","DOI":"10.1021\/acs.jpcb.1c06725"},{"key":"ref12\/cit12","doi-asserted-by":"publisher","DOI":"10.1038\/35081564"},{"key":"ref13\/cit13","doi-asserted-by":"publisher","DOI":"10.1126\/science.276.5321.2045"},{"key":"ref14\/cit14","doi-asserted-by":"publisher","DOI":"10.1038\/ng0298-106"},{"key":"ref15\/cit15","doi-asserted-by":"publisher","DOI":"10.1021\/ar050073t"},{"key":"ref16\/cit16","doi-asserted-by":"publisher","DOI":"10.1021\/acs.biochem.8b00575"},{"key":"ref17\/cit17","doi-asserted-by":"publisher","DOI":"10.1021\/bi0259857"},{"key":"ref18\/cit18","doi-asserted-by":"publisher","DOI":"10.1021\/acs.chemrev.6b00163"},{"key":"ref19\/cit19","volume-title":"GROMACS 2022 1.Manual","author":"Bauer P.","year":"2022"},{"key":"ref20\/cit20","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M411805200"},{"key":"ref21\/cit21","volume-title":"The PyMOL Molecular Graphics System, Version 1.8","author":"Schr\u00f6dinger, LLC.","year":"2015"},{"key":"ref22\/cit22","doi-asserted-by":"publisher","DOI":"10.1021\/ct300646g"},{"key":"ref23\/cit23","doi-asserted-by":"publisher","DOI":"10.1021\/acs.jctc.1c01042"},{"key":"ref24\/cit24","doi-asserted-by":"publisher","DOI":"10.1002\/jcc.21224"},{"key":"ref25\/cit25","doi-asserted-by":"publisher","DOI":"10.1021\/acs.jcim.3c00513"},{"key":"ref26\/cit26","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pcbi.1000810"},{"key":"ref27\/cit27","doi-asserted-by":"publisher","DOI":"10.1063\/1.448118"},{"key":"ref28\/cit28","doi-asserted-by":"publisher","DOI":"10.1063\/1.2408420"},{"key":"ref29\/cit29","doi-asserted-by":"publisher","DOI":"10.1063\/1.328693"},{"key":"ref30\/cit30","doi-asserted-by":"publisher","DOI":"10.1021\/ct700200b"},{"key":"ref31\/cit31","doi-asserted-by":"publisher","DOI":"10.1038\/nsmb.3194"},{"key":"ref32\/cit32","doi-asserted-by":"publisher","DOI":"10.1016\/0021-9991(77)90121-8"},{"key":"ref33\/cit33","doi-asserted-by":"publisher","DOI":"10.1021\/ct100494z"},{"key":"ref34\/cit34","doi-asserted-by":"publisher","DOI":"10.1002\/jcc.540130812"},{"key":"ref35\/cit35","doi-asserted-by":"publisher","DOI":"10.1529\/biophysj.106.081406"},{"key":"ref36\/cit36","doi-asserted-by":"publisher","DOI":"10.1021\/acschemneuro.4c00557"},{"key":"ref37\/cit37","doi-asserted-by":"publisher","DOI":"10.1021\/ct400617g"},{"key":"ref38\/cit38","doi-asserted-by":"publisher","DOI":"10.1038\/nmeth.4067"},{"key":"ref39\/cit39","doi-asserted-by":"publisher","DOI":"10.1021\/jp508971m"},{"key":"ref40\/cit40","doi-asserted-by":"publisher","DOI":"10.1063\/1.464397"},{"key":"ref41\/cit41","doi-asserted-by":"publisher","DOI":"10.1021\/acs.macromol.1c02550"},{"key":"ref42\/cit42","doi-asserted-by":"publisher","DOI":"10.3389\/fmolb.2021.654333"},{"key":"ref43\/cit43","doi-asserted-by":"publisher","DOI":"10.1021\/jp9110794"},{"key":"ref44\/cit44","doi-asserted-by":"publisher","DOI":"10.1016\/S1353-8020(13)70010-5"},{"key":"ref45\/cit45","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1604645113"},{"key":"ref46\/cit46","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-025-58374-5"},{"key":"ref47\/cit47","doi-asserted-by":"publisher","DOI":"10.1021\/acsnano.8b03575"},{"key":"ref48\/cit48","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.97.2.571"},{"key":"ref49\/cit49","doi-asserted-by":"publisher","DOI":"10.1186\/s40035-019-0165-9"},{"key":"ref50\/cit50","doi-asserted-by":"publisher","DOI":"10.14802\/jmd.16061"},{"key":"ref51\/cit51","doi-asserted-by":"publisher","DOI":"10.1002\/mds.25499"},{"key":"ref52\/cit52","doi-asserted-by":"publisher","DOI":"10.1021\/acs.chemrev.8b00038"},{"key":"ref53\/cit53","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1100976108"},{"key":"ref54\/cit54","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M112.443812"},{"key":"ref55\/cit55","doi-asserted-by":"publisher","DOI":"10.1038\/nrd3050"},{"key":"ref56\/cit56","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1315346111"}],"container-title":["The Journal of Physical Chemistry B"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/pubs.acs.org\/doi\/pdf\/10.1021\/acs.jpcb.6c00859","content-type":"application\/pdf","content-version":"vor","intended-application":"unspecified"},{"URL":"https:\/\/pubs.acs.org\/doi\/pdf\/10.1021\/acs.jpcb.6c00859","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,6,11]],"date-time":"2026-06-11T08:10:55Z","timestamp":1781165455000},"score":1,"resource":{"primary":{"URL":"https:\/\/pubs.acs.org\/doi\/10.1021\/acs.jpcb.6c00859"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,5,28]]},"references-count":56,"journal-issue":{"issue":"23","published-print":{"date-parts":[[2026,6,11]]}},"alternative-id":["10.1021\/acs.jpcb.6c00859"],"URL":"https:\/\/doi.org\/10.1021\/acs.jpcb.6c00859","relation":{},"ISSN":["1520-6106","1520-5207"],"issn-type":[{"value":"1520-6106","type":"print"},{"value":"1520-5207","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,5,28]]}}}