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Numerous studies have been conducted on A\u03b2\u2019s characteristics, revealing its antibacterial and antiviral properties. Indeed, A\u03b2 can bind to molecules attached to the surface of cell membranes, such as GM1 ganglioside, which are also known as points of entry for viruses. This binding could then explain its antiviral properties, as it may prevent the binding of proteins found on the surface of viruses. All-atom molecular dynamics simulations on protein-membrane systems were conducted to investigate this process. The selected proteins were A\u03b242, A\u03b240, VP1 from simian virus 40, VP8* from rotavirus, and HSV-1gD (herpes simplex virus 1). These last three viral proteins are already known to interact with either GM1 or A\u03b2. The membrane was a bilayer containing five different lipids (phospholipids, cholesterol, and GM1). Protein-membrane interactions were studied through the formation of hydrogen bonds and salt bridges over time, and the quantification of the interaction energies. Favorable interactions were observed between all studied proteins and GM1 lipids, especially for VP8*, where a strong network of interactions with the arginine residues was identified. Moreover, we demonstrate that a larger protein does not necessarily result in higher interaction energies, suggesting that smaller peptides may compete with these larger proteins.<\/jats:p>","DOI":"10.1021\/acs.jpcb.6c01436","type":"journal-article","created":{"date-parts":[[2026,6,29]],"date-time":"2026-06-29T10:46:26Z","timestamp":1782729986000},"page":"6739-6750","source":"Crossref","is-referenced-by-count":0,"title":["Computational Insights\ninto the Antiviral Properties\nof the Antimicrobial Peptide \u03b2-Amyloid"],"prefix":"10.1021","volume":"130","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4342-5928","authenticated-orcid":true,"given":"He\u0301loi\u0308se","family":"Leboucher","sequence":"first","affiliation":[{"name":"Krembil Research Institute , , , ,","place":["Toronto, Ontario, Canada, M5T 0S8"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2042-6220","authenticated-orcid":true,"given":"Donald F.","family":"Weaver","sequence":"additional","affiliation":[{"name":"Krembil Research Institute , , , ,","place":["Toronto, Ontario, Canada, M5T 0S8"]},{"name":"University of Toronto , , , ,","place":["Toronto, Ontario, Canada, M5S 1A1"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"316","published-online":{"date-parts":[[2026,6,29]]},"reference":[{"key":"2026090714124784100_cit1","doi-asserted-by":"publisher","first-page":"2115","DOI":"10.1111\/febs.13725","article-title":"A New Cryptic Cationic Antimicrobial Peptide from Human Apolipoprotein\nE with Antibacterial Activity and Immunomodulatory Effects on Human\nCells","volume":"283","author":"Pane","year":"2016","journal-title":"FEBS J."},{"key":"2026090714124784100_cit2","doi-asserted-by":"publisher","first-page":"R906","DOI":"10.1016\/j.cub.2006.09.056","article-title":"Alzheimer\u2019s\nDiscovery","volume":"16","author":"Dahm","year":"2006","journal-title":"Curr. 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Virol."},{"key":"2026090714124784100_cit34","doi-asserted-by":"publisher","first-page":"476","DOI":"10.1038\/343476a0","article-title":"Localization\nof VP4 Neutralization Sites in Rotavirus by Three-Dimensional Cryo-Electron\nMicroscopy","volume":"343","author":"Prasad","year":"1990","journal-title":"Nature"},{"key":"2026090714124784100_cit35","doi-asserted-by":"publisher","first-page":"553","DOI":"10.1016\/0042-6822(91)90888-I","article-title":"The VP8 Fragment of VP4 Is the Rhesus\nRotavirus Hemagglutinin","volume":"181","author":"Fiore","year":"1991","journal-title":"Virology"},{"key":"2026090714124784100_cit36","doi-asserted-by":"publisher","first-page":"4558","DOI":"10.1128\/JVI.03431-13","article-title":"Relative Roles of GM1 Ganglioside,\nN-Acylneuraminic Acids, and A2\u03b21 Integrin in\nMediating Rotavirus Infection","volume":"88","author":"Fleming","year":"2014","journal-title":"J. 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