{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T14:05:03Z","timestamp":1790863503257,"version":"4.1.0"},"reference-count":60,"publisher":"American Chemical Society (ACS)","issue":"39","license":[{"start":{"date-parts":[[2026,9,21]],"date-time":"2026-09-21T00:00:00Z","timestamp":1789948800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026,10,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Chemical communication between artificial cells (ACs) is crucial for the collective behavior in synthetic prototissues. Recently synthesized ACs show pH-responsive and pH-modifying behavior by an enzymatic chemical reaction. However, the chemical interplay between pH-responsive ACs is theoretically not well studied. Here, we report a simple two-variable model for such ACs that couples substrate conversion, enzyme activity, membrane permeability, and pH-buffering. We calibrate the model to recent experiments of glucose oxidase- and urease-loaded ACs, and reproduce a protection mechanism against external acid or base perturbations. Building on the derived models we predict the dynamics of AC-mixtures of the two antagonistic ACs. Depending on composition and initial pH, the mixtures exhibit a stable low-pH state, a stable high-pH state, or bistability, providing a minimal route to hysteretic pH control in AC-communities. On longer time scales, fuel depletion leads to transient states with programmable pH and lifetime. Our results demonstrate the potential of chemical communication in AC-systems and provide testable design rules for future experiments.<\/jats:p>","DOI":"10.1021\/acs.jpcb.6c03926","type":"journal-article","created":{"date-parts":[[2026,9,21]],"date-time":"2026-09-21T20:03:05Z","timestamp":1790020985000},"page":"10269-10278","source":"Crossref","is-referenced-by-count":0,"title":["Chemical Feedback\nand Collective pH-Dynamics in Enzyme-Powered\nArtificial Cells"],"prefix":"10.1021","volume":"130","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0051-2845","authenticated-orcid":true,"given":"Nils","family":"Go\u0308th","sequence":"first","affiliation":[{"name":"Albert-Ludwigs-Universita\u0308t Freiburg , , ,","place":["Freiburg, Germany, D-79104"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6751-1487","authenticated-orcid":true,"given":"Joachim","family":"Dzubiella","sequence":"additional","affiliation":[{"name":"Albert-Ludwigs-Universita\u0308t Freiburg , , ,","place":["Freiburg, Germany, D-79104"]},{"name":"Albert-Ludwigs-Universita\u0308t Freiburg , , ,","place":["Freiburg, Germany, D-79110"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"316","published-online":{"date-parts":[[2026,9,21]]},"reference":[{"key":"2026100109061276900_cit1","doi-asserted-by":"publisher","first-page":"319","DOI":"10.1146\/annurev.cellbio.21.012704.131001","article-title":"Quorum sensing: Cell-to-cell communication in bacteria","volume":"21","author":"Waters","year":"2005","journal-title":"Annu. 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