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Moreover, their ring flips serve as sensitive probes of protein breathing motions. In this work, we accurately estimate the ring-flip rates of a phenylalanine residue in cytochrome C from MD simulations using enhanced sampling methods and advanced rate theories, such as the reactive flux formalism and Grote\u2013Hynes theory (GHT). We demonstrate that the combined steric hindrance from the residues adjacent to the ring, along with their delayed response in accommodating free rotation, manifests as memory-dependent friction. Increasing solvent viscosity slows the fluctuations of these cavity residues, reinforcing the delayed response and producing a fractional viscosity dependence of the flip rate despite the ring being completely buried.<\/jats:p>","DOI":"10.1021\/acs.jpcb.6c04066","type":"journal-article","created":{"date-parts":[[2026,9,25]],"date-time":"2026-09-25T17:02:08Z","timestamp":1790355728000},"page":"10418-10426","source":"Crossref","is-referenced-by-count":0,"title":["Protein Breathing\nInduces Non-Markovian Buried Ring-Flip\nDynamics in Cytochrome C"],"prefix":"10.1021","volume":"130","author":[{"given":"Bikirna","family":"Roy","sequence":"first","affiliation":[{"name":"Indian Institute of Science Education and Research Pune , , Dr. Homi Bhabha Road , Pashan, , ,","place":["Pune, Maharashtra, India, 411008"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5691-6120","authenticated-orcid":true,"given":"Arnab","family":"Mukherjee","sequence":"additional","affiliation":[{"name":"Indian Institute of Science Education and Research Pune , , Dr. Homi Bhabha Road , Pashan, , ,","place":["Pune, Maharashtra, India, 411008"]},{"name":"Indian Institute of Science Education and Research Pune , , Dr. Homi Bhabha Road , Pashan, , ,","place":["Pune, Maharashtra, India, 411008"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"316","published-online":{"date-parts":[[2026,9,25]]},"reference":[{"key":"2026100809093108000_cit1","doi-asserted-by":"publisher","first-page":"695","DOI":"10.1038\/s41586-022-04417-6","article-title":"Visualizing protein breathing motions\nassociated with aromatic ring flipping","volume":"602","author":"Marin\u0303o Pe\u0301rez","year":"2022","journal-title":"Nature"},{"key":"2026100809093108000_cit2","doi-asserted-by":"publisher","first-page":"591","DOI":"10.1021\/acs.jpcb.2c07258","article-title":"NMR Studies\nof Aromatic Ring Flips to Probe Conformational\nFluctuations in Proteins","volume":"127","author":"Akke","year":"2023","journal-title":"J. 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