{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,8]],"date-time":"2026-10-08T14:01:43Z","timestamp":1791468103348,"version":"4.3.4"},"reference-count":56,"publisher":"American Chemical Society (ACS)","issue":"40","license":[{"start":{"date-parts":[[2026,9,26]],"date-time":"2026-09-26T00:00:00Z","timestamp":1790380800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2026,9,26]],"date-time":"2026-09-26T00:00:00Z","timestamp":1790380800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2026,9,26]],"date-time":"2026-09-26T00:00:00Z","timestamp":1790380800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-045"}],"funder":[{"DOI":"10.13039\/501100002979","name":"Dalian Institute of Chemical Physics, Chinese Academy of Sciences","doi-asserted-by":"publisher","award":["DICP I202436"],"award-info":[{"award-number":["DICP I202436"]}],"id":[{"id":"10.13039\/501100002979","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002979","name":"Dalian Institute of Chemical Physics, Chinese Academy of Sciences","doi-asserted-by":"publisher","award":["DICP I202512"],"award-info":[{"award-number":["DICP I202512"]}],"id":[{"id":"10.13039\/501100002979","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002979","name":"Dalian Institute of Chemical Physics, Chinese Academy of Sciences","doi-asserted-by":"publisher","award":["DICP I202522"],"award-info":[{"award-number":["DICP I202522"]}],"id":[{"id":"10.13039\/501100002979","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002979","name":"Dalian Institute of Chemical Physics, Chinese Academy of Sciences","doi-asserted-by":"publisher","award":["DICP&SIA UN202502"],"award-info":[{"award-number":["DICP&SIA UN202502"]}],"id":[{"id":"10.13039\/501100002979","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002979","name":"Dalian Institute of Chemical Physics, Chinese Academy of Sciences","doi-asserted-by":"publisher","award":["DMU-1&DICP UN202301"],"award-info":[{"award-number":["DMU-1&DICP UN202301"]}],"id":[{"id":"10.13039\/501100002979","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002979","name":"Dalian Institute of Chemical Physics, Chinese Academy of Sciences","doi-asserted-by":"publisher","award":["DMU-1&DICP UN202302"],"award-info":[{"award-number":["DMU-1&DICP UN202302"]}],"id":[{"id":"10.13039\/501100002979","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002979","name":"Dalian Institute of Chemical Physics, Chinese Academy of Sciences","doi-asserted-by":"publisher","award":["DMU-2&DICP UN202502"],"award-info":[{"award-number":["DMU-2&DICP UN202502"]}],"id":[{"id":"10.13039\/501100002979","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100009965","name":"Dalian Science and Technology Bureau","doi-asserted-by":"publisher","award":["2022JJ11CG007"],"award-info":[{"award-number":["2022JJ11CG007"]}],"id":[{"id":"10.13039\/501100009965","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100005047","name":"Natural Science Foundation of Liaoning Province","doi-asserted-by":"publisher","award":["2025-BS-0147"],"award-info":[{"award-number":["2025-BS-0147"]}],"id":[{"id":"10.13039\/501100005047","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100005047","name":"Natural Science Foundation of Liaoning Province","doi-asserted-by":"publisher","award":["2025-MS-061"],"award-info":[{"award-number":["2025-MS-061"]}],"id":[{"id":"10.13039\/501100005047","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100007620","name":"Department of Education of Liaoning Province","doi-asserted-by":"publisher","award":["LJ222510161004"],"award-info":[{"award-number":["LJ222510161004"]}],"id":[{"id":"10.13039\/501100007620","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["22225806"],"award-info":[{"award-number":["22225806"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["22278394"],"award-info":[{"award-number":["22278394"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["22522816"],"award-info":[{"award-number":["22522816"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["22541705"],"award-info":[{"award-number":["22541705"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["U25A20620"],"award-info":[{"award-number":["U25A20620"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002367","name":"Chinese Academy of Sciences","doi-asserted-by":"publisher","award":["YSBR-104"],"award-info":[{"award-number":["YSBR-104"]}],"id":[{"id":"10.13039\/501100002367","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Yulin Innovation Institute of Clean Energy","award":["E412050705"],"award-info":[{"award-number":["E412050705"]}]},{"name":"Liaoning Binhai Laboratory","award":["LBLD-2024-07"],"award-info":[{"award-number":["LBLD-2024-07"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026,10,8]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Although photodynamic therapy (PDT) has emerged as a promising treatment for unresectable cholangiocarcinoma, the hypoxic tumor microenvironment severely limits oxygen-dependent Type II photochemical processes, resulting in insufficient reactive oxygen species (ROS) generation and compromised therapeutic outcomes. Therefore, developing Type I photosensitizers (PSs) with optimized excited-state dynamics and efficient hypoxia-tolerant ROS generation is critical for improving PDT efficacy under hypoxic conditions. Herein, we developed three hemicyanine-based Type I PSs (HCy1\u20133) and systematically investigated the relationship between molecular structure, TICT-mediated excited-state relaxation, and ROS generation behavior. By modulating the electron-donating capability of donor moieties, the TICT characteristics of the hemicyanine scaffold were precisely tuned, thereby regulating the competition between nonradiative decay and ROS-generating pathways. Among them, HCy3 exhibited enhanced excited-state utilization and the highest Type I ROS generation efficiency under both normoxic and hypoxic conditions. Furthermore, HCy3 efficiently accumulated in mitochondria and induced mitochondrial dysfunction, leading to superior photodynamic cytotoxicity against cholangiocarcinoma cells under hypoxia compared with the clinically used PS HiPorfin. The therapeutic potential of HCy3 was further validated in cholangiocarcinoma organoids. This study establishes a structure\u2013photophysics-photochemistry correlation between TICT regulation and Type I ROS generation, providing a mechanistic strategy for designing high-performance hypoxia-tolerant PSs for PDT.<\/jats:p>","DOI":"10.1021\/acs.jpcb.6c05556","type":"journal-article","created":{"date-parts":[[2026,9,26]],"date-time":"2026-09-26T15:02:09Z","timestamp":1790434929000},"page":"10488-10496","source":"Crossref","is-referenced-by-count":0,"title":["Tuning Excited-State\nTICT Dynamics in Hemicyanine\nType I Photosensitizers for Hypoxia-Tolerant Photodynamic Therapy\nof Cholangiocarcinoma"],"prefix":"10.1021","volume":"130","author":[{"given":"Yiyan","family":"Ruan","sequence":"first","affiliation":[{"name":"Chinese Academy of Sciences , , ,","place":["Dalian, China, 116023"]},{"name":"University of Chinese Academy of Sciences , ,","place":["Beijing, China, 100049"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qinglong","family":"Qiao","sequence":"additional","affiliation":[{"name":"Chinese Academy of Sciences , , ,","place":["Dalian, China, 116023"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wenchao","family":"Jiang","sequence":"additional","affiliation":[{"name":"Chinese Academy of Sciences , , ,","place":["Dalian, China, 116023"]},{"name":"University of Chinese Academy of Sciences , ,","place":["Beijing, China, 100049"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiang","family":"Wang","sequence":"additional","affiliation":[{"name":"The Second Hospital of Dalian Medical University , , ,","place":["Dalian, China, 116011"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guixin","family":"Zhang","sequence":"additional","affiliation":[{"name":"The Second Hospital of Dalian Medical University , , ,","place":["Dalian, China, 116011"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2491-8938","authenticated-orcid":true,"given":"Zhaochao","family":"Xu","sequence":"additional","affiliation":[{"name":"Chinese Academy of Sciences , , ,","place":["Dalian, China, 116023"]},{"name":"University of Chinese Academy of Sciences , ,","place":["Beijing, China, 100049"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"316","published-online":{"date-parts":[[2026,9,26]]},"reference":[{"issue":"9","key":"2026100809093166800_cit1","doi-asserted-by":"publisher","first-page":"557","DOI":"10.1038\/s41575-020-0310-z","article-title":"Cholangiocarcinoma 2020: the next\nhorizon in mechanisms and management","volume":"17","author":"Banales","year":"2020","journal-title":"Nat. Rev.\nGastroenterol. Hepatol."},{"issue":"1","key":"2026100809093166800_cit2","doi-asserted-by":"publisher","first-page":"65","DOI":"10.1038\/s41575-025-01153-w","article-title":"International CCA Consensus\nConsortium. Cholangiocarcinoma 2026: status quo, unmet needs and priorities","volume":"23","author":"Banales","year":"2026","journal-title":"Nat. Rev. Gastroenterol. Hepatol."},{"issue":"2","key":"2026100809093166800_cit3","doi-asserted-by":"publisher","first-page":"95","DOI":"10.1038\/nrclinonc.2017.157","article-title":"Cholangiocarcinoma\n- evolving concepts and therapeutic strategies","volume":"15","author":"Ilyas","year":"2018","journal-title":"Nat. Rev. Clin. Oncol."},{"issue":"1","key":"2026100809093166800_cit4","doi-asserted-by":"publisher","first-page":"95","DOI":"10.1016\/j.jhep.2019.09.007","article-title":"Risk factors for intrahepatic and extrahepatic cholangiocarcinoma:\nA systematic review and meta-analysis","volume":"72","author":"Clements","year":"2020","journal-title":"J. Hepatol."},{"key":"2026100809093166800_cit5","doi-asserted-by":"publisher","first-page":"8085","DOI":"10.2147\/CMAR.S276104","article-title":"Optimal Management\nof Patients with\nAdvanced or Metastatic Cholangiocarcinoma: An Evidence-Based Review","volume":"13","author":"Ioffe","year":"2021","journal-title":"Cancer Manage. Res."},{"issue":"14","key":"2026100809093166800_cit6","doi-asserted-by":"publisher","first-page":"1273","DOI":"10.1056\/nejmoa0908721","article-title":"Cisplatin plus Gemcitabine versus Gemcitabine for Biliary\nTract Cancer","volume":"362","author":"Valle","year":"2010","journal-title":"N. Engl. J. Med."},{"issue":"20","key":"2026100809093166800_cit7","doi-asserted-by":"publisher","first-page":"5074","DOI":"10.3390\/cancers13205074","article-title":"Quality of Life\nand Symptom Management in Advanced\nBiliary Tract Cancers","volume":"13","author":"Hunter","year":"2021","journal-title":"Cancers"},{"issue":"4","key":"2026100809093166800_cit8","doi-asserted-by":"publisher","first-page":"250","DOI":"10.3322\/caac.20114","article-title":"Photodynamic\ntherapy of cancer: An update","volume":"61","author":"Agostinis","year":"2011","journal-title":"Ca-Cancer J. Clin."},{"issue":"1","key":"2026100809093166800_cit9","doi-asserted-by":"publisher","first-page":"46","DOI":"10.1038\/s41570-024-00662-7","article-title":"Smart molecular\ndesigns and applications of activatable organic photosensitizers","volume":"9","author":"Nestoros","year":"2025","journal-title":"Nat. Rev. Chem."},{"issue":"4","key":"2026100809093166800_cit10","doi-asserted-by":"publisher","first-page":"1174","DOI":"10.1039\/C7CS00594F","article-title":"Supramolecular photosensitizers rejuvenate\nphotodynamic\ntherapy","volume":"47","author":"Li","year":"2018","journal-title":"Chem. Soc. Rev."},{"issue":"23","key":"2026100809093166800_cit11","doi-asserted-by":"publisher","first-page":"6597","DOI":"10.1039\/C6CS00271D","article-title":"Reactive oxygen species\ngenerating systems meeting challenges of photodynamic cancer therapy","volume":"45","author":"Zhou","year":"2016","journal-title":"Chem. Soc. Rev."},{"issue":"6","key":"2026100809093166800_cit12","doi-asserted-by":"publisher","first-page":"4185","DOI":"10.1039\/D0CS00173B","article-title":"Recent progress in\nphotosensitizers for overcoming the challenges of photodynamic therapy:\nfrom molecular design to application","volume":"50","author":"Zhao","year":"2021","journal-title":"Chem.\nSoc. Rev."},{"issue":"4","key":"2026100809093166800_cit13","doi-asserted-by":"publisher","first-page":"500","DOI":"10.1067\/mge.2001.113386","article-title":"Endoscopic application\nof photodynamic therapy for\ncholangiocarcinoma","volume":"53","author":"Rumalla","year":"2001","journal-title":"Gastrointest. Endosc."},{"issue":"4","key":"2026100809093166800_cit14","doi-asserted-by":"publisher","first-page":"345","DOI":"10.3904\/kjim.2010.25.4.345","article-title":"The role\nof photodynamic therapy for hilar cholangiocarcinoma","volume":"25","author":"Cheon","year":"2010","journal-title":"Korean J. Intern. Med."},{"issue":"10","key":"2026100809093166800_cit15","doi-asserted-by":"publisher","first-page":"5655","DOI":"10.1007\/s00464-020-08095-1","article-title":"Long-term\nresults of ERCP- or PTCS-directed photodynamic therapy for unresectable\nhilar cholangiocarcinoma","volume":"35","author":"Li","year":"2021","journal-title":"Surg. Endosc."},{"issue":"3","key":"2026100809093166800_cit16","doi-asserted-by":"publisher","first-page":"185","DOI":"10.1111\/j.1477-2574.2011.00424.x","article-title":"Longterm\noutcome of photodynamic therapy compared with biliary stenting alone\nin patients with advanced hilar cholangiocarcinoma","volume":"14","author":"Cheon","year":"2012","journal-title":"HPB"},{"issue":"2","key":"2026100809093166800_cit17","doi-asserted-by":"publisher","first-page":"137","DOI":"10.1007\/s005340170036","article-title":"Photodynamic\ntherapy for cholangiocarcinoma","volume":"8","author":"Ortner","year":"2001","journal-title":"J. Hepatobiliary\nPancreat. Sci."},{"issue":"3","key":"2026100809093166800_cit18","doi-asserted-by":"publisher","first-page":"536","DOI":"10.1016\/S0016-5085(98)70537-2","article-title":"Photodynamic therapy\nof nonresectable cholangiocarcinoma","volume":"114","author":"Ortner","year":"1998","journal-title":"Gastroenterology"},{"issue":"5","key":"2026100809093166800_cit19","doi-asserted-by":"publisher","first-page":"472","DOI":"10.1097\/MOG.0b013e32832e6e1f","article-title":"Photodynamic\ntherapy for cholangiocarcinoma: overview and new developments","volume":"25","author":"Ortner","year":"2009","journal-title":"Curr. Opin. Gastroenterol."},{"key":"2026100809093166800_cit20","doi-asserted-by":"publisher","first-page":"102712","DOI":"10.1016\/j.pdpdt.2022.102712","article-title":"Benefits and safety of photodynamic\ntherapy in patients with hilar\ncholangiocarcinoma: A meta-analysis","volume":"37","author":"Chen","year":"2022","journal-title":"Photodiagn.\nPhotodyn. Ther."},{"issue":"21","key":"2026100809093166800_cit21","doi-asserted-by":"publisher","first-page":"13454","DOI":"10.1021\/acs.chemrev.1c00381","article-title":"Recent Strategies\nto Develop Innovative Photosensitizers for Enhanced Photodynamic Therapy","volume":"121","author":"Pham","year":"2021","journal-title":"Chem. Rev."},{"issue":"31","key":"2026100809093166800_cit22","doi-asserted-by":"publisher","first-page":"2006742","DOI":"10.1002\/smll.202006742","article-title":"Type I Photosensitizers\nRevitalizing Photodynamic Oncotherapy","volume":"17","author":"Chen","year":"2021","journal-title":"Small"},{"issue":"1","key":"2026100809093166800_cit23","doi-asserted-by":"publisher","first-page":"81","DOI":"10.3390\/biom12010081","article-title":"Recent Advances\nin Strategies for\nAddressing Hypoxia in Tumor Photodynamic Therapy","volume":"12","author":"Hong","year":"2022","journal-title":"Biomolecules"},{"issue":"8","key":"2026100809093166800_cit24","doi-asserted-by":"publisher","first-page":"1500","DOI":"10.1039\/C7BM00392G","article-title":"Manipulating tumor hypoxia toward\nenhanced photodynamic therapy (PDT)","volume":"5","author":"Dang","year":"2017","journal-title":"Biomater.\nSci."},{"issue":"2","key":"2026100809093166800_cit25","doi-asserted-by":"publisher","first-page":"137","DOI":"10.3390\/biomedicines9020137","article-title":"Nanomedicine-Based\nStrategies Assisting Photodynamic Therapy for Hypoxic Tumors: State-of-the-Art\nApproaches and Emerging Trends","volume":"9","author":"Shih","year":"2021","journal-title":"Biomedicines"},{"issue":"8","key":"2026100809093166800_cit26","doi-asserted-by":"publisher","first-page":"1500","DOI":"10.1039\/C7BM00392G","article-title":"Manipulating tumor hypoxia toward\nenhanced photodynamic therapy (PDT)","volume":"5","author":"Dang","year":"2017","journal-title":"Biomater.\nSci."},{"issue":"9","key":"2026100809093166800_cit27","doi-asserted-by":"publisher","first-page":"1763","DOI":"10.3390\/pharmaceutics14091763","article-title":"Recent Strategies to Address Hypoxic\nTumor Environments in Photodynamic Therapy","volume":"14","author":"Du","year":"2022","journal-title":"Pharmaceutics"},{"issue":"11","key":"2026100809093166800_cit28","doi-asserted-by":"publisher","first-page":"4748","DOI":"10.3390\/ijms27114748","article-title":"Overcoming Tumor Hypoxia\nin Photodynamic Therapy: A\nComprehensive Review of Oxygen-Delivery Carriers and Type I Photosensitizers","volume":"27","author":"Bartusik-Aebisher","year":"2026","journal-title":"Int. J. Mol. Sci."},{"issue":"1","key":"2026100809093166800_cit29","doi-asserted-by":"publisher","first-page":"39","DOI":"10.1038\/s41427-021-00303-1","article-title":"Strategies\nto improve photodynamic therapy efficacy by relieving\nthe tumor hypoxia environment","volume":"13","author":"Shen","year":"2021","journal-title":"NPG Asia Mater."},{"issue":"15","key":"2026100809093166800_cit30","doi-asserted-by":"publisher","first-page":"7025","DOI":"10.1039\/D1CS01079D","article-title":"New guidelines\nand definitions for\ntype I photodynamic therapy","volume":"54","author":"Li","year":"2025","journal-title":"Chem. Soc. Rev."},{"issue":"21","key":"2026100809093166800_cit31","doi-asserted-by":"publisher","first-page":"4600","DOI":"10.1039\/D3TB00545C","article-title":"Recent advances in\ntype I organic photosensitizers for efficient photodynamic therapy\nfor overcoming tumor hypoxia","volume":"11","author":"Lu","year":"2023","journal-title":"J. Mater. Chem.\nB"},{"issue":"1","key":"2026100809093166800_cit32","doi-asserted-by":"publisher","first-page":"100775","DOI":"10.1016\/j.ajps.2023.100775","article-title":"Innovative\nstrategies for photodynamic therapy against hypoxic tumor","volume":"18","author":"Li","year":"2023","journal-title":"Asian J. Pharm. Sci."},{"issue":"1","key":"2026100809093166800_cit33","doi-asserted-by":"publisher","first-page":"332","DOI":"10.3390\/molecules28010332","article-title":"Recent\nProgress in Type I Aggregation-Induced Emission Photosensitizers for\nPhotodynamic Therapy","volume":"28","author":"Yu","year":"2022","journal-title":"Molecules"},{"issue":"7","key":"2026100809093166800_cit34","doi-asserted-by":"publisher","DOI":"10.1002\/advs.202413365","article-title":"The Current Advances\nin Design Strategy (Indirect Strategy and Direct Strategy) for Type-I\nPhotosensitizers","volume":"12","author":"Ma","year":"2025","journal-title":"Adv. Sci."},{"issue":"5","key":"2026100809093166800_cit35","doi-asserted-by":"publisher","first-page":"1795","DOI":"10.1039\/D1CS00307K","article-title":"Activity-based\nNIR fluorescent probes\nbased on the versatile hemicyanine scaffold: design strategy, biomedical\napplications, and outlook","volume":"51","author":"Li","year":"2022","journal-title":"Chem. Soc. Rev."},{"issue":"51","key":"2026100809093166800_cit36","doi-asserted-by":"publisher","first-page":"26454","DOI":"10.1002\/anie.202107877","article-title":"Hemicyanine-Based Near-Infrared\nActivatable Probes for Imaging and Diagnosis of Diseases","volume":"60","author":"Zeng","year":"2021","journal-title":"Angew. Chem., Int. Ed."},{"issue":"22","key":"2026100809093166800_cit37","doi-asserted-by":"publisher","first-page":"7750","DOI":"10.3390\/molecules27227750","article-title":"Activity-Based\nFluorescent Probes Based on Hemicyanine for Biomedical Sensing","volume":"27","author":"Luo","year":"2022","journal-title":"Molecules"},{"issue":"15","key":"2026100809093166800_cit38","doi-asserted-by":"publisher","first-page":"5985","DOI":"10.1021\/acs.analchem.4c00342","article-title":"Stable Super-Resolution\nImaging of Cell Membrane Nanoscale Subcompartment\nDynamics with a Buffering Cyanine Dye","volume":"96","author":"An","year":"2024","journal-title":"Anal.\nChem."},{"issue":"18","key":"2026100809093166800_cit39","doi-asserted-by":"publisher","first-page":"4786","DOI":"10.1039\/D2SC06710B","article-title":"Monitoring\namyloid aggregation via a twisted intramolecular charge transfer (TICT)-based\nfluorescent sensor array","volume":"14","author":"Wang","year":"2023","journal-title":"Chem. Sci."},{"issue":"1","key":"2026100809093166800_cit40","doi-asserted-by":"publisher","first-page":"341","DOI":"10.1039\/D3CS00585B","article-title":"Design strategies and\napplications\nof cyanine dyes in phototherapy","volume":"54","author":"Yuan","year":"2025","journal-title":"Chem. Soc.\nRev."},{"issue":"14","key":"2026100809093166800_cit41","doi-asserted-by":"publisher","first-page":"2731","DOI":"10.1039\/C5TC03933A","article-title":"Recent\nadvances in twisted intramolecular\ncharge transfer (TICT) fluorescence and related phenomena in materials\nchemistry","volume":"4","author":"Sasaki","year":"2016","journal-title":"J. Mater. Chem. C"},{"issue":"20","key":"2026100809093166800_cit42","doi-asserted-by":"publisher","first-page":"22552","DOI":"10.1021\/acsami.0c03894","article-title":"Aggregation-Dependent\nPhotoreactive Hemicyanine Assembly as a Photobactericide","volume":"12","author":"Tian","year":"2020","journal-title":"ACS Appl. Mater. Interfaces"},{"issue":"39","key":"2026100809093166800_cit43","doi-asserted-by":"publisher","DOI":"10.1002\/anie.202306061","article-title":"Spontaneously\nBlinking\nRhodamine Dyes for Single-Molecule Localization Microscopy","volume":"62","author":"Chi","year":"2023","journal-title":"Angew. Chem., Int. Ed."},{"issue":"7","key":"2026100809093166800_cit44","doi-asserted-by":"publisher","first-page":"2282","DOI":"10.1016\/j.biomaterials.2011.11.073","article-title":"A pyrene-imidazolium derivative that\nselectively Recognizes G-Quadruplex DNA","volume":"33","author":"Kim","year":"2012","journal-title":"Biomaterials"},{"issue":"11","key":"2026100809093166800_cit45","doi-asserted-by":"publisher","first-page":"4943","DOI":"10.1016\/j.cclet.2022.03.121","article-title":"A TICS-fluorophore\nbased probe for dual-color GSH imaging","volume":"33","author":"Liu","year":"2022","journal-title":"Chin.\nChem. Lett."},{"issue":"10","key":"2026100809093166800_cit46","doi-asserted-by":"publisher","first-page":"110984","DOI":"10.1016\/j.cclet.2025.110984","article-title":"Dye-mediated\nFRET strategy for constructing semi-synthetic large Stokes shift far-red\nfluorescent protein","volume":"36","author":"Zhou","year":"2025","journal-title":"Chin. Chem. Lett."},{"issue":"8","key":"2026100809093166800_cit47","doi-asserted-by":"publisher","first-page":"110643","DOI":"10.1016\/j.cclet.2024.110643","article-title":"Super-resolution\nimaging of cellular\npseudopodia dynamics with a target-specific blinkogenic probe","volume":"36","author":"Song","year":"2025","journal-title":"Chin. Chem. Lett."},{"issue":"5","key":"2026100809093166800_cit48","doi-asserted-by":"publisher","first-page":"110258","DOI":"10.1016\/j.cclet.2024.110258","article-title":"FRET-based in vitro assay for rapid\ndetecting of SARS-CoV-2 entry inhibitors","volume":"36","author":"Yan","year":"2025","journal-title":"Chin.\nChem. Lett."},{"issue":"Suppl. 1","key":"2026100809093166800_cit49","doi-asserted-by":"publisher","first-page":"14","DOI":"10.1159\/000362416","article-title":"Photodynamic\ntherapy: current status and future directions","volume":"24","author":"Benov","year":"2015","journal-title":"Med. Princ. Pract."},{"issue":"4","key":"2026100809093166800_cit50","doi-asserted-by":"publisher","first-page":"1041","DOI":"10.1039\/C9CS00129H","article-title":"The unique features and promises\nof phthalocyanines as advanced photosensitisers for photodynamic therapy\nof cancer","volume":"49","author":"Lo","year":"2020","journal-title":"Chem. Soc. Rev."},{"issue":"7","key":"2026100809093166800_cit51","doi-asserted-by":"publisher","DOI":"10.1002\/advs.202305761","article-title":"Aryl-Modified Pentamethyl\nCyanine Dyes at the C2\u2019 Position: A Tunable Platform for Activatable\nPhotosensitizers","volume":"11","author":"Han","year":"2024","journal-title":"Adv. Sci."},{"issue":"10","key":"2026100809093166800_cit52","doi-asserted-by":"publisher","first-page":"974","DOI":"10.1038\/nchem.2550","article-title":"Switchable\nphotooxygenation catalysts that sense higher-order amyloid structures","volume":"8","author":"Taniguchi","year":"2016","journal-title":"Nat. Chem."},{"issue":"2","key":"2026100809093166800_cit53","doi-asserted-by":"publisher","first-page":"143","DOI":"10.1038\/s41563-021-01057-5","article-title":"Next-generation\ncancer organoids","volume":"21","author":"LeSavage","year":"2022","journal-title":"Nat. Mater."},{"issue":"8","key":"2026100809093166800_cit54","doi-asserted-by":"publisher","first-page":"2465","DOI":"10.1158\/0008-5472.CAN-15-2402","article-title":"A Three-Dimensional Organoid Culture\nSystem Derived\nfrom Human Glioblastomas Recapitulates the Hypoxic Gradients and Cancer\nStem Cell Heterogeneity of Tumors Found In Vivo","volume":"76","author":"Hubert","year":"2016","journal-title":"Cancer Res."},{"issue":"8","key":"2026100809093166800_cit55","doi-asserted-by":"publisher","first-page":"523","DOI":"10.1038\/s41568-024-00706-6","article-title":"Cancer organoids 2.0: modelling the\ncomplexity of the tumour immune microenvironment","volume":"24","author":"Polak","year":"2024","journal-title":"Nat. Rev. Cancer"},{"issue":"1","key":"2026100809093166800_cit56","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1007\/s13402-024-00960-8","article-title":"A systematic\nreview on the culture methods and applications of 3D tumoroids for\ncancer research and personalized medicine","volume":"48","author":"Kalla","year":"2025","journal-title":"Cell.\nOncol."}],"container-title":["The Journal of Physical\nChemistry B"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/pubs.acs.org\/doi\/pdf\/10.1021\/acs.jpcb.6c05556","content-type":"application\/pdf","content-version":"vor","intended-application":"unspecified"},{"URL":"https:\/\/pubs.acs.org\/jpcbfk\/article-pdf\/130\/40\/10488\/68666561\/acs.jpcb.6c05556.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/pubs.acs.org\/jpcbfk\/article-pdf\/130\/40\/10488\/68666561\/acs.jpcb.6c05556.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,10,8]],"date-time":"2026-10-08T13:24:30Z","timestamp":1791465870000},"score":1,"resource":{"primary":{"URL":"https:\/\/pubs.acs.org\/jpcbfk\/article\/130\/40\/10488\/5439343\/Tuning-Excited-State-TICT-Dynamics-in-Hemicyanine"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,9,26]]},"references-count":56,"journal-issue":{"issue":"40","published-online":{"date-parts":[[2026,9,26]]},"published-print":{"date-parts":[[2026,10,8]]}},"URL":"https:\/\/doi.org\/10.1021\/acs.jpcb.6c05556","relation":{},"ISSN":["1520-6106","1520-5207"],"issn-type":[{"value":"1520-6106","type":"print"},{"value":"1520-5207","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,9,26]]}}}