{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T14:31:09Z","timestamp":1787063469948,"version":"build-2736575974"},"reference-count":66,"publisher":"American Chemical Society (ACS)","issue":"27","license":[{"start":{"date-parts":[[2022,7,7]],"date-time":"2022-07-07T00:00:00Z","timestamp":1657152000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2022,7,7]],"date-time":"2022-07-07T00:00:00Z","timestamp":1657152000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2022,7,7]],"date-time":"2022-07-07T00:00:00Z","timestamp":1657152000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-045"}],"funder":[{"DOI":"10.13039\/100004316","name":"International Business Machines Corporation","doi-asserted-by":"publisher","award":["W125859"],"award-info":[{"award-number":["W125859"]}],"id":[{"id":"10.13039\/100004316","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100004316","name":"International Business Machines Corporation","doi-asserted-by":"publisher","award":["W1464125"],"award-info":[{"award-number":["W1464125"]}],"id":[{"id":"10.13039\/100004316","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100004316","name":"International Business Machines Corporation","doi-asserted-by":"publisher","award":["W1464164"],"award-info":[{"award-number":["W1464164"]}],"id":[{"id":"10.13039\/100004316","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004835","name":"Zhejiang University","doi-asserted-by":"publisher","award":["SN-ZJU-SIAS-003"],"award-info":[{"award-number":["SN-ZJU-SIAS-003"]}],"id":[{"id":"10.13039\/501100004835","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002855","name":"Ministry of Science and Technology of the People's Republic of China","doi-asserted-by":"publisher","award":["2021YFF1200404"],"award-info":[{"award-number":["2021YFF1200404"]}],"id":[{"id":"10.13039\/501100002855","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100005725","name":"CHDI Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100005725","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100018594","name":"Central University Basic Research Fund of China","doi-asserted-by":"publisher","award":["226-2022-00043"],"award-info":[{"award-number":["226-2022-00043"]}],"id":[{"id":"10.13039\/501100018594","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100018594","name":"Central University Basic Research Fund of China","doi-asserted-by":"publisher","award":["226-2022-00192"],"award-info":[{"award-number":["226-2022-00192"]}],"id":[{"id":"10.13039\/501100018594","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000888","name":"W. M. Keck Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000888","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["U1967217"],"award-info":[{"award-number":["U1967217"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"name":"National Independent Innovation Demonstration Zone Shanghai Zhangjiang Major Projects","award":["ZJZX2020014"],"award-info":[{"award-number":["ZJZX2020014"]}]},{"name":"Biren Technology","award":["BR-ZJU-SIAS-001"],"award-info":[{"award-number":["BR-ZJU-SIAS-001"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J. Phys. Chem. Lett."],"published-print":{"date-parts":[[2022,7,14]]},"DOI":"10.1021\/acs.jpclett.2c01184","type":"journal-article","created":{"date-parts":[[2022,7,7]],"date-time":"2022-07-07T07:23:16Z","timestamp":1657178596000},"page":"6331-6341","source":"Crossref","is-referenced-by-count":9,"title":["Possible Co-Evolution of Polyglutamine and Polyproline in Huntingtin Protein: Proline-Rich Domain as Transient Folding Chaperone"],"prefix":"10.1021","volume":"13","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2952-4858","authenticated-orcid":true,"given":"Leili","family":"Zhang","sequence":"first","affiliation":[{"name":"Computational Biology Center, IBM Thomas J. Watson Research Center, Yorktown Heights, New York 10598, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hongsuk","family":"Kang","sequence":"additional","affiliation":[{"name":"Computational Biology Center, IBM Thomas J. Watson Research Center, Yorktown Heights, New York 10598, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9893-5992","authenticated-orcid":true,"given":"Jose Manuel","family":"Perez-Aguilar","sequence":"additional","affiliation":[{"name":"School of Chemical Sciences, Meritorious Autonomous University of Puebla (BUAP), University City, Puebla 72570, Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8624-5591","authenticated-orcid":true,"given":"Ruhong","family":"Zhou","sequence":"additional","affiliation":[{"name":"Computational Biology Center, IBM Thomas J. Watson Research Center, Yorktown Heights, New York 10598, United States"},{"name":"Institute of Quantitative Biology, College of Life Sciences, Zhejiang University, Hangzhou 310027, China"},{"name":"Department of Chemistry, Columbia University, New York, New York 10027, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"316","published-online":{"date-parts":[[2022,7,7]]},"reference":[{"key":"ref1\/cit1","doi-asserted-by":"publisher","DOI":"10.1038\/378403a0"},{"key":"ref2\/cit2","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M109.093708"},{"key":"ref3\/cit3","doi-asserted-by":"publisher","DOI":"10.1038\/nature13136"},{"key":"ref4\/cit4","doi-asserted-by":"publisher","DOI":"10.1038\/nrn1806"},{"key":"ref5\/cit5","doi-asserted-by":"publisher","DOI":"10.1016\/S0092-8674(00)81782-1"},{"key":"ref6\/cit6","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0308679101"},{"key":"ref7\/cit7","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.97.4.1589"},{"key":"ref8\/cit8","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1717978115"},{"key":"ref9\/cit9","doi-asserted-by":"publisher","DOI":"10.1002\/1531-8249(199912)46:6<842::AID-ANA6>3.0.CO;2-O"},{"key":"ref10\/cit10","doi-asserted-by":"publisher","DOI":"10.1093\/hmg\/9.1.133"},{"key":"ref11\/cit11","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0604547103"},{"key":"ref12\/cit12","doi-asserted-by":"publisher","DOI":"10.1038\/nature25502"},{"key":"ref13\/cit13","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-017-01510-z"},{"key":"ref14\/cit14","doi-asserted-by":"publisher","DOI":"10.1021\/jacs.6b10893"},{"key":"ref15\/cit15","doi-asserted-by":"publisher","DOI":"10.1038\/nsmb.1570"},{"key":"ref16\/cit16","doi-asserted-by":"publisher","DOI":"10.1016\/j.bpj.2013.06.030"},{"key":"ref17\/cit17","doi-asserted-by":"publisher","DOI":"10.1021\/acs.jpcb.7b01476"},{"key":"ref18\/cit18","doi-asserted-by":"publisher","DOI":"10.1093\/hmg\/dds554"},{"key":"ref19\/cit19","doi-asserted-by":"publisher","DOI":"10.1093\/hmg\/ddm217"},{"key":"ref20\/cit20","doi-asserted-by":"publisher","DOI":"10.1093\/hmg\/ddl440"},{"key":"ref21\/cit21","doi-asserted-by":"publisher","DOI":"10.1038\/ncomms15462"},{"key":"ref22\/cit22","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1521933113"},{"key":"ref23\/cit23","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.2747-08.2008"},{"key":"ref24\/cit24","doi-asserted-by":"publisher","DOI":"10.1093\/hmg\/7.9.1463"},{"key":"ref25\/cit25","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.272.13.8121"},{"key":"ref26\/cit26","doi-asserted-by":"publisher","DOI":"10.1063\/1.5053922"},{"key":"ref27\/cit27","doi-asserted-by":"publisher","DOI":"10.1038\/372375a0"},{"key":"ref28\/cit28","doi-asserted-by":"publisher","DOI":"10.1016\/j.jmb.2013.03.018"},{"key":"ref29\/cit29","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0053785"},{"key":"ref30\/cit30","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1320626110"},{"key":"ref31\/cit31","doi-asserted-by":"publisher","DOI":"10.1016\/j.jmb.2005.10.053"},{"key":"ref32\/cit32","doi-asserted-by":"publisher","DOI":"10.1016\/j.jmb.2006.06.044"},{"key":"ref33\/cit33","doi-asserted-by":"publisher","DOI":"10.1016\/j.jmb.2007.09.023"},{"key":"ref34\/cit34","doi-asserted-by":"publisher","DOI":"10.1016\/j.bpj.2009.07.062"},{"key":"ref35\/cit35","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0604548103"},{"key":"ref36\/cit36","doi-asserted-by":"publisher","DOI":"10.1016\/j.arcmed.2007.06.015"},{"key":"ref37\/cit37","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pcbi.1000772"},{"key":"ref38\/cit38","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1702237114"},{"key":"ref39\/cit39","doi-asserted-by":"publisher","DOI":"10.1021\/acschemneuro.9b00561"},{"key":"ref40\/cit40","doi-asserted-by":"publisher","DOI":"10.1093\/molbev\/msm258"},{"key":"ref41\/cit41","doi-asserted-by":"publisher","DOI":"10.7717\/peerj.911"},{"key":"ref42\/cit42","doi-asserted-by":"publisher","DOI":"10.1016\/j.str.2020.04.008"},{"key":"ref43\/cit43","doi-asserted-by":"publisher","DOI":"10.1186\/s12862-020-01705-5"},{"key":"ref44\/cit44","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0608175103"},{"key":"ref45\/cit45","doi-asserted-by":"publisher","DOI":"10.1016\/j.jmb.2008.09.026"},{"key":"ref46\/cit46","doi-asserted-by":"publisher","DOI":"10.1021\/jacs.7b00838"},{"key":"ref47\/cit47","doi-asserted-by":"publisher","DOI":"10.1016\/j.jmb.2018.03.017"},{"key":"ref48\/cit48","doi-asserted-by":"publisher","DOI":"10.1016\/j.jmb.2013.01.016"},{"key":"ref49\/cit49","doi-asserted-by":"publisher","DOI":"10.1038\/nsmb1215"},{"key":"ref50\/cit50","doi-asserted-by":"publisher","DOI":"10.1016\/S0959-440X(03)00032-0"},{"key":"ref51\/cit51","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.2002570117"},{"key":"ref52\/cit52","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M117.813667"},{"key":"ref53\/cit53","doi-asserted-by":"publisher","DOI":"10.1016\/j.jmb.2015.03.021"},{"key":"ref54\/cit54","doi-asserted-by":"publisher","DOI":"10.1016\/j.jmb.2018.03.031"},{"key":"ref55\/cit55","doi-asserted-by":"publisher","DOI":"10.1021\/ja110715f"},{"key":"ref56\/cit56","doi-asserted-by":"publisher","DOI":"10.1021\/ct900202f"},{"key":"ref57\/cit57","doi-asserted-by":"publisher","DOI":"10.1002\/jcb.28338"},{"key":"ref58\/cit58","doi-asserted-by":"publisher","DOI":"10.1021\/jacs.7b06659"},{"key":"ref59\/cit59","doi-asserted-by":"publisher","DOI":"10.1021\/bi00184a020"},{"key":"ref60\/cit60","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbrc.2006.01.159"},{"key":"ref61\/cit61","doi-asserted-by":"publisher","DOI":"10.1042\/bj2970249"},{"key":"ref62\/cit62","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.262544899"},{"key":"ref63\/cit63","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0000504"},{"key":"ref64\/cit64","doi-asserted-by":"publisher","DOI":"10.1126\/stke.2003.179.re8"},{"key":"ref65\/cit65","doi-asserted-by":"publisher","DOI":"10.1016\/S0968-0004(01)01957-0"},{"key":"ref66\/cit66","doi-asserted-by":"publisher","DOI":"10.2174\/156720510791162377"}],"container-title":["The Journal of Physical Chemistry Letters"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/pubs.acs.org\/doi\/pdf\/10.1021\/acs.jpclett.2c01184","content-type":"application\/pdf","content-version":"vor","intended-application":"unspecified"},{"URL":"https:\/\/pubs.acs.org\/doi\/pdf\/10.1021\/acs.jpclett.2c01184","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,4,25]],"date-time":"2023-04-25T14:38:31Z","timestamp":1682433511000},"score":1,"resource":{"primary":{"URL":"https:\/\/pubs.acs.org\/doi\/10.1021\/acs.jpclett.2c01184"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,7,7]]},"references-count":66,"journal-issue":{"issue":"27","published-print":{"date-parts":[[2022,7,14]]}},"alternative-id":["10.1021\/acs.jpclett.2c01184"],"URL":"https:\/\/doi.org\/10.1021\/acs.jpclett.2c01184","relation":{},"ISSN":["1948-7185","1948-7185"],"issn-type":[{"value":"1948-7185","type":"print"},{"value":"1948-7185","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,7,7]]}}}