{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,26]],"date-time":"2026-02-26T18:01:19Z","timestamp":1772128879700,"version":"3.50.1"},"reference-count":39,"publisher":"American Chemical Society (ACS)","issue":"51","license":[{"start":{"date-parts":[[2024,12,17]],"date-time":"2024-12-17T00:00:00Z","timestamp":1734393600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2024,12,17]],"date-time":"2024-12-17T00:00:00Z","timestamp":1734393600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2024,12,17]],"date-time":"2024-12-17T00:00:00Z","timestamp":1734393600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-045"}],"funder":[{"DOI":"10.13039\/501100020027","name":"Dr. Rolf M. Schwiete Stiftung","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100020027","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100005110","name":"Alfons und Gertrud Kassel-Stiftung","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100005110","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003495","name":"Hessisches Ministerium f?r Wissenschaft und Kunst","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003495","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J. Phys. Chem. Lett."],"published-print":{"date-parts":[[2024,12,26]]},"DOI":"10.1021\/acs.jpclett.4c02875","type":"journal-article","created":{"date-parts":[[2024,12,17]],"date-time":"2024-12-17T07:36:24Z","timestamp":1734420984000},"page":"12643-12651","source":"Crossref","is-referenced-by-count":4,"title":["G-Protein-Coupled Receptor Surface Creates a Favorable Pathway for Membrane Permeation of Drug Molecules"],"prefix":"10.1021","volume":"15","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4882-7950","authenticated-orcid":true,"given":"Cristina","family":"Gil Herrero","sequence":"first","affiliation":[{"name":"Frankfurt Institute for Advanced Studies, Ruth-Moufang-Stra\u00dfe 1, 60438 Frankfurt am Main, Germany"},{"name":"Faculty of Biochemistry, Chemistry and Pharmacy","place":["Frankfurt am Main, Germany"]},{"name":"Goethe University Frankfurt","place":["Frankfurt am Main, Germany"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3396-5840","authenticated-orcid":true,"given":"Sebastian","family":"Thallmair","sequence":"additional","affiliation":[{"name":"Frankfurt Institute for Advanced Studies, Ruth-Moufang-Stra\u00dfe 1, 60438 Frankfurt am Main, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"316","published-online":{"date-parts":[[2024,12,17]]},"reference":[{"key":"ref1\/cit1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1810316115"},{"key":"ref2\/cit2","doi-asserted-by":"publisher","DOI":"10.1124\/mol.117.111062"},{"key":"ref3\/cit3","doi-asserted-by":"publisher","DOI":"10.1038\/nature08144"},{"key":"ref4\/cit4","doi-asserted-by":"publisher","DOI":"10.3389\/fnagi.2016.00058"},{"key":"ref5\/cit5","doi-asserted-by":"publisher","DOI":"10.14348\/molcells.2015.2301"},{"key":"ref6\/cit6","doi-asserted-by":"publisher","DOI":"10.1146\/annurev-biophys-090821-083030"},{"key":"ref7\/cit7","doi-asserted-by":"publisher","DOI":"10.1038\/ncomms6115"},{"key":"ref8\/cit8","doi-asserted-by":"publisher","DOI":"10.1016\/j.jbc.2024.105649"},{"key":"ref9\/cit9","doi-asserted-by":"publisher","DOI":"10.1016\/j.str.2017.11.020"},{"key":"ref10\/cit10","doi-asserted-by":"publisher","DOI":"10.1016\/j.str.2018.01.014"},{"key":"ref11\/cit11","doi-asserted-by":"publisher","DOI":"10.1007\/s00018-006-6167-7"},{"key":"ref12\/cit12","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0050186"},{"key":"ref13\/cit13","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2005.11.012"},{"key":"ref14\/cit14","doi-asserted-by":"publisher","DOI":"10.1053\/rmed.2001.1139"},{"key":"ref15\/cit15","doi-asserted-by":"publisher","DOI":"10.1038\/s41589-018-0145-x"},{"key":"ref16\/cit16","doi-asserted-by":"publisher","DOI":"10.1063\/9780735425279_001"},{"key":"ref17\/cit17","doi-asserted-by":"publisher","DOI":"10.1038\/s41592-021-01098-3"},{"key":"ref18\/cit18","doi-asserted-by":"publisher","DOI":"10.1002\/adts.202100391"},{"issue":"2","key":"ref19\/cit19","first-page":"180","volume":"75","author":"Pearlman D. S.","year":"1995","journal-title":"Ann. Allergy, Asthma, Immunol."},{"key":"ref20\/cit20","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-022-30300-z"},{"key":"ref21\/cit21","doi-asserted-by":"publisher","DOI":"10.1016\/j.str.2024.01.012"},{"key":"ref22\/cit22","doi-asserted-by":"publisher","DOI":"10.1016\/j.str.2008.05.001"},{"key":"ref23\/cit23","doi-asserted-by":"publisher","DOI":"10.1126\/science.1150577"},{"key":"ref24\/cit24","doi-asserted-by":"publisher","DOI":"10.1021\/acs.jctc.3c00547"},{"key":"ref25\/cit25","doi-asserted-by":"publisher","DOI":"10.1016\/j.cplett.2023.140436"},{"key":"ref26\/cit26","doi-asserted-by":"publisher","DOI":"10.1021\/acs.jctc.2c00950"},{"key":"ref27\/cit27","doi-asserted-by":"publisher","DOI":"10.1101\/2024.04.15.589479"},{"key":"ref28\/cit28","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-020-17437-5"},{"key":"ref29\/cit29","doi-asserted-by":"publisher","DOI":"10.1007\/s40265-017-0723-3"},{"key":"ref30\/cit30","doi-asserted-by":"publisher","DOI":"10.1172\/JCI141772"},{"key":"ref31\/cit31","doi-asserted-by":"publisher","DOI":"10.1016\/j.jsps.2019.01.012"},{"key":"ref32\/cit32","doi-asserted-by":"publisher","DOI":"10.1007\/978-3-319-91439-8_2"},{"key":"ref33\/cit33","doi-asserted-by":"publisher","DOI":"10.3389\/fncel.2020.00139"},{"key":"ref34\/cit34","doi-asserted-by":"publisher","DOI":"10.1016\/j.bpj.2014.06.024"},{"key":"ref35\/cit35","doi-asserted-by":"publisher","DOI":"10.1016\/j.softx.2015.06.001"},{"key":"ref36\/cit36","doi-asserted-by":"publisher","DOI":"10.1002\/jcc.23354"},{"key":"ref37\/cit37","doi-asserted-by":"publisher","DOI":"10.1021\/ja9621760"},{"key":"ref38\/cit38","doi-asserted-by":"publisher","DOI":"10.1038\/s41586-021-03819-2"},{"key":"ref39\/cit39","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gkab1061"}],"container-title":["The Journal of Physical Chemistry Letters"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/pubs.acs.org\/doi\/pdf\/10.1021\/acs.jpclett.4c02875","content-type":"application\/pdf","content-version":"vor","intended-application":"unspecified"},{"URL":"https:\/\/pubs.acs.org\/doi\/pdf\/10.1021\/acs.jpclett.4c02875","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,2,25]],"date-time":"2025-02-25T09:35:53Z","timestamp":1740476153000},"score":1,"resource":{"primary":{"URL":"https:\/\/pubs.acs.org\/doi\/10.1021\/acs.jpclett.4c02875"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,12,17]]},"references-count":39,"journal-issue":{"issue":"51","published-print":{"date-parts":[[2024,12,26]]}},"alternative-id":["10.1021\/acs.jpclett.4c02875"],"URL":"https:\/\/doi.org\/10.1021\/acs.jpclett.4c02875","relation":{"has-preprint":[{"id-type":"doi","id":"10.1101\/2024.03.18.585530","asserted-by":"object"}]},"ISSN":["1948-7185","1948-7185"],"issn-type":[{"value":"1948-7185","type":"print"},{"value":"1948-7185","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,12,17]]}}}