{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,15]],"date-time":"2026-06-15T10:55:03Z","timestamp":1781520903959,"version":"3.54.1"},"reference-count":46,"publisher":"American Chemical Society (ACS)","issue":"25","license":[{"start":{"date-parts":[[2026,6,15]],"date-time":"2026-06-15T00:00:00Z","timestamp":1781481600000},"content-version":"vor","delay-in-days":368,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/100000057","name":"National Institute of General Medical Sciences","doi-asserted-by":"publisher","award":["R35GM130587"],"award-info":[{"award-number":["R35GM130587"]}],"id":[{"id":"10.13039\/100000057","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000057","name":"National Institute of General Medical Sciences","doi-asserted-by":"publisher","award":["R35GM146888"],"award-info":[{"award-number":["R35GM146888"]}],"id":[{"id":"10.13039\/100000057","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J. Phys. Chem. Lett."],"published-print":{"date-parts":[[2025,6,26]]},"DOI":"10.1021\/acs.jpclett.5c00467","type":"journal-article","created":{"date-parts":[[2025,6,12]],"date-time":"2025-06-12T19:35:12Z","timestamp":1749756912000},"page":"6273-6278","source":"Crossref","is-referenced-by-count":2,"title":["Multiple Molecule \u03bb-Dynamics: Probing Drug Resistance with Concurrent Protein and Ligand Perturbations"],"prefix":"10.1021","volume":"16","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1758-595X","authenticated-orcid":true,"given":"Michael P.","family":"Liesen","sequence":"first","affiliation":[{"name":"Department of Biochemistry and Molecular Biology","place":["Indianapolis, United States"]},{"name":"Indiana University School of Medicine","place":["Indianapolis, United States"]},{"name":"Center for Computational Biology and Bioinformatics","place":["Indianapolis, United States"]},{"name":"Indiana University School of Medicine","place":["Indianapolis, United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1052-6391","authenticated-orcid":true,"given":"Ryan L.","family":"Hayes","sequence":"additional","affiliation":[{"name":"Department of Chemical and Biomolecular Engineering","place":["Irvine, United States"]},{"name":"University of California Irvine","place":["Irvine, United States"]},{"name":"Department of Pharmaceutical Sciences","place":["Irvine, United States"]},{"name":"University of California Irvine","place":["Irvine, United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8149-5417","authenticated-orcid":true,"given":"Charles L.","family":"Brooks III","sequence":"additional","affiliation":[{"name":"Department of Chemistry","place":["Ann Arbor, United States"]},{"name":"University of Michigan","place":["Ann Arbor, United States"]},{"name":"Biophysics Program","place":["Ann Arbor, United States"]},{"name":"University of Michigan","place":["Ann Arbor, United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7076-8996","authenticated-orcid":true,"given":"Jonah Z.","family":"Vilseck","sequence":"additional","affiliation":[{"name":"Department of Biochemistry and Molecular Biology","place":["Indianapolis, United States"]},{"name":"Indiana University School of Medicine","place":["Indianapolis, United States"]},{"name":"Center for Computational Biology and Bioinformatics","place":["Indianapolis, United States"]},{"name":"Indiana University School of Medicine","place":["Indianapolis, United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"316","published-online":{"date-parts":[[2025,6,12]]},"reference":[{"key":"ref1\/cit1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.chemrev.0c00648"},{"key":"ref2\/cit2","doi-asserted-by":"publisher","DOI":"10.1021\/acs.chemrev.1c00118"},{"key":"ref3\/cit3","doi-asserted-by":"publisher","DOI":"10.1016\/j.sbi.2011.01.011"},{"key":"ref4\/cit4","doi-asserted-by":"publisher","DOI":"10.1126\/science.1096361"},{"key":"ref5\/cit5","doi-asserted-by":"publisher","DOI":"10.1021\/acs.jpclett.8b01284"},{"key":"ref6\/cit6","doi-asserted-by":"publisher","DOI":"10.1021\/acs.jcim.0c00900"},{"key":"ref7\/cit7","doi-asserted-by":"publisher","DOI":"10.1021\/acs.accounts.7b00083"},{"key":"ref8\/cit8","doi-asserted-by":"publisher","DOI":"10.1021\/cr00023a004"},{"key":"ref9\/cit9","doi-asserted-by":"publisher","DOI":"10.1016\/j.sbi.2018.09.002"},{"key":"ref10\/cit10","doi-asserted-by":"publisher","DOI":"10.1063\/1.4769292"},{"key":"ref11\/cit11","doi-asserted-by":"publisher","DOI":"10.1021\/acs.jcim.0c00547"},{"key":"ref12\/cit12","doi-asserted-by":"publisher","DOI":"10.1021\/ja512751q"},{"key":"ref13\/cit13","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1717932115"},{"key":"ref14\/cit14","doi-asserted-by":"publisher","DOI":"10.1021\/acs.jcim.0c00815"},{"key":"ref15\/cit15","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.2111451118"},{"key":"ref16\/cit16","doi-asserted-by":"publisher","DOI":"10.1038\/s42003-018-0075-x"},{"key":"ref17\/cit17","doi-asserted-by":"publisher","DOI":"10.1021\/acs.jctc.1c01005"},{"key":"ref18\/cit18","doi-asserted-by":"publisher","DOI":"10.1021\/acscentsci.9b00590"},{"key":"ref19\/cit19","doi-asserted-by":"publisher","DOI":"10.1002\/jcc.26979"},{"key":"ref20\/cit20","doi-asserted-by":"publisher","DOI":"10.1063\/1.2730508"},{"key":"ref21\/cit21","doi-asserted-by":"publisher","DOI":"10.1021\/acs.jpcb.8b02725"},{"key":"ref22\/cit22","doi-asserted-by":"publisher","DOI":"10.1002\/jcc.21295"},{"key":"ref23\/cit23","doi-asserted-by":"publisher","DOI":"10.1063\/1.472109"},{"key":"ref24\/cit24","doi-asserted-by":"publisher","DOI":"10.1021\/ct200444f"},{"key":"ref25\/cit25","doi-asserted-by":"publisher","DOI":"10.1021\/acs.jpcb.6b09656"},{"key":"ref26\/cit26","doi-asserted-by":"publisher","DOI":"10.1002\/pro.3500"},{"key":"ref27\/cit27","doi-asserted-by":"publisher","DOI":"10.1021\/acs.jpclett.9b02004"},{"key":"ref28\/cit28","doi-asserted-by":"publisher","DOI":"10.1021\/acs.jctc.1c00948"},{"key":"ref29\/cit29","doi-asserted-by":"publisher","DOI":"10.1021\/acs.jctc.4c00514"},{"key":"ref30\/cit30","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.2312029121"},{"key":"ref31\/cit31","doi-asserted-by":"publisher","DOI":"10.1002\/jcc.540040211"},{"key":"ref32\/cit32","doi-asserted-by":"publisher","DOI":"10.1002\/jcc.21287"},{"key":"ref33\/cit33","doi-asserted-by":"publisher","DOI":"10.1021\/acs.jmedchem.5b01125"},{"key":"ref34\/cit34","doi-asserted-by":"publisher","DOI":"10.1111\/j.1747-0285.2010.01054.x"},{"key":"ref35\/cit35","doi-asserted-by":"publisher","DOI":"10.1016\/j.chembiol.2013.06.001"},{"key":"ref36\/cit36","doi-asserted-by":"publisher","DOI":"10.1021\/acs.jctc.1c00833"},{"key":"ref37\/cit37","doi-asserted-by":"publisher","DOI":"10.1002\/jcc.540130812"},{"key":"ref38\/cit38","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-023-44208-9"},{"key":"ref39\/cit39","doi-asserted-by":"publisher","DOI":"10.1021\/ct500894k"},{"key":"ref40\/cit40","doi-asserted-by":"publisher","DOI":"10.1021\/acs.jctc.8b00825"},{"key":"ref41\/cit41","doi-asserted-by":"publisher","DOI":"10.1021\/acs.jctc.4c00954"},{"key":"ref42\/cit42","doi-asserted-by":"publisher","DOI":"10.1016\/j.bmc.2016.06.034"},{"key":"ref43\/cit43","doi-asserted-by":"publisher","DOI":"10.1021\/acs.jcim.7b00564"},{"key":"ref44\/cit44","doi-asserted-by":"publisher","DOI":"10.1021\/acs.jctc.0c00830"},{"key":"ref45\/cit45","doi-asserted-by":"publisher","DOI":"10.1021\/acs.jpcb.4c04805"},{"key":"ref46\/cit46","doi-asserted-by":"publisher","unstructured":"Liesen, M. P.; Vilseck, J. Z. Input scripts for Multiple Molecule \u03bb-Dynamics: Probing Drug Resistance with Concurrent Protein and Ligand Perturbations.\n                      Zenodo\n                      . 2025. 10.5281\/zenodo.15320832.","DOI":"10.5281\/zenodo.15320832"}],"container-title":["The Journal of Physical Chemistry Letters"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/pubs.acs.org\/doi\/pdf\/10.1021\/acs.jpclett.5c00467","content-type":"application\/pdf","content-version":"vor","intended-application":"unspecified"},{"URL":"https:\/\/pubs.acs.org\/doi\/pdf\/10.1021\/acs.jpclett.5c00467","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,6,15]],"date-time":"2026-06-15T10:23:08Z","timestamp":1781518988000},"score":1,"resource":{"primary":{"URL":"https:\/\/pubs.acs.org\/doi\/10.1021\/acs.jpclett.5c00467"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,6,12]]},"references-count":46,"journal-issue":{"issue":"25","published-print":{"date-parts":[[2025,6,26]]}},"alternative-id":["10.1021\/acs.jpclett.5c00467"],"URL":"https:\/\/doi.org\/10.1021\/acs.jpclett.5c00467","relation":{"has-preprint":[{"id-type":"doi","id":"10.26434\/chemrxiv-2025-m0129","asserted-by":"object"}]},"ISSN":["1948-7185","1948-7185"],"issn-type":[{"value":"1948-7185","type":"print"},{"value":"1948-7185","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,6,12]]}}}