{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T19:29:20Z","timestamp":1786994960387,"version":"build-2736575974"},"reference-count":84,"publisher":"American Chemical Society (ACS)","issue":"7","license":[{"start":{"date-parts":[[2020,4,28]],"date-time":"2020-04-28T00:00:00Z","timestamp":1588032000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2020,4,28]],"date-time":"2020-04-28T00:00:00Z","timestamp":1588032000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2020,4,28]],"date-time":"2020-04-28T00:00:00Z","timestamp":1588032000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-045"}],"funder":[{"DOI":"10.13039\/501100009553","name":"Agentura Pro Zdravotnick? V?zkum Cesk? Republiky","doi-asserted-by":"publisher","award":["NV19-08-00250"],"award-info":[{"award-number":["NV19-08-00250"]}],"id":[{"id":"10.13039\/501100009553","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001824","name":"Grantov? Agentura Cesk? Republiky","doi-asserted-by":"publisher","award":["17-05957S"],"award-info":[{"award-number":["17-05957S"]}],"id":[{"id":"10.13039\/501100001824","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2020,7,2]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>A specific form of endometrial cancer (EC) can develop in breast cancer patients previously treated with tamoxifen (ET), an antagonist of estrogen receptor (ER) that inhibits proliferation of ER positive breast cancer. ET tumors have a different phenotype than endometrial tumors, which typically develop de novo without previous exposure to tamoxifen (EN). Here we aimed to identify specific protein markers that could serve as specific molecular targets in either phenotype. A set of total 45 formalin-fixed paraffin-embedded (FFPE) endometrial tumor tissues and adjacent myometrium tissue samples were analyzed using LC\u2013MS\/MS in SWATH-MS mode. We found that calcyphosin (CAPS) levels were elevated in EN tumors compared to ET tumors. The higher CAPS level in EC tissue invading to myometrium supports its relationship to EC aggressiveness. Further, stathmin (STMN1) levels were found significantly elevated in ET versus EN tumors and significantly associated with patient survival. This finding connects elevated levels of this cell cycle regulating, proliferation-associated protein with tamoxifen exposure. In summary, using SWATH-MS we show that CAPS and STMN1 should be recognized as clinicopathologically different EC markers of which STMN1 is specifically connected with a previous tamoxifen exposition.<\/jats:p>","DOI":"10.1021\/acs.jproteome.0c00064","type":"journal-article","created":{"date-parts":[[2020,4,28]],"date-time":"2020-04-28T12:55:09Z","timestamp":1588078509000},"page":"2617-2630","source":"Crossref","is-referenced-by-count":21,"title":["SWATH-MS Analysis\nof FFPE Tissues Identifies Stathmin\nas a Potential Marker of Endometrial Cancer in Patients Exposed to\nTamoxifen"],"prefix":"10.1021","volume":"19","author":[{"given":"Lucia","family":"Janacova","sequence":"first","affiliation":[{"name":"Masaryk University , , ,","place":["Brno, Czech Republic, 62500"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jakub","family":"Faktor","sequence":"additional","affiliation":[{"name":"Masaryk Memorial Cancer Institute , , ,","place":["Brno, Czech\nRepublic, 65653"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lenka","family":"Capkova","sequence":"additional","affiliation":[{"name":"Masaryk University , , ,","place":["Brno, Czech Republic, 62500"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vendula","family":"Paralova","sequence":"additional","affiliation":[{"name":"Masaryk University , , ,","place":["Brno, Czech Republic, 62500"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anna","family":"Pospisilova","sequence":"additional","affiliation":[{"name":"Masaryk University , , ,","place":["Brno, Czech Republic, 62500"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jan","family":"Podhorec","sequence":"additional","affiliation":[{"name":"Masaryk Memorial Cancer Institute , , ,","place":["Brno, Czech\nRepublic, 65653"]},{"name":"Masaryk Memorial Cancer Institute , , ,","place":["Brno, Czech Republic"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Holger Alexander","family":"Ebhardt","sequence":"additional","affiliation":[{"name":"Swiss Federal Institute for Technology (ETH) Zurich , , ,","place":["Zurich, Switzerland"]},{"name":"University College Dublin , , ,","place":["Dublin, Ireland"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Roman","family":"Hrstka","sequence":"additional","affiliation":[{"name":"Masaryk Memorial Cancer Institute , , ,","place":["Brno, Czech\nRepublic, 65653"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rudolf","family":"Nenutil","sequence":"additional","affiliation":[{"name":"Masaryk Memorial Cancer Institute , , ,","place":["Brno, Czech\nRepublic, 65653"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ruedi","family":"Aebersold","sequence":"additional","affiliation":[{"name":"Swiss Federal Institute for Technology (ETH) Zurich , , ,","place":["Zurich, Switzerland"]},{"name":"University of Zurich , , ,","place":["Zurich, Switzerland"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7118-4113","authenticated-orcid":true,"given":"Pavel","family":"Bouchal","sequence":"additional","affiliation":[{"name":"Masaryk University , , ,","place":["Brno, Czech Republic, 62500"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"316","published-online":{"date-parts":[[2020,4,28]]},"reference":[{"key":"2026081714243607200_cit1","doi-asserted-by":"publisher","first-page":"373","DOI":"10.1016\/j.ygyno.2010.02.007","article-title":"Treatment\noptions for advanced endometrial carcinoma","volume":"117","author":"Dizon","year":"2010","journal-title":"Gynecol. Oncol."},{"key":"2026081714243607200_cit2","doi-asserted-by":"publisher","first-page":"1495","DOI":"10.3892\/ol.2015.2962","article-title":"Molecular mechanisms\nof tamoxifen-associated\nendometrial cancer (Review)","volume":"9","author":"Hu","year":"2015","journal-title":"Oncol. Lett."},{"key":"2026081714243607200_cit3","doi-asserted-by":"publisher","first-page":"1","DOI":"10.17265\/2328-7136\/2016.01.001","article-title":"Tamoxifen Treatment\nand Risk of Endometrial Cancer: An Overview","volume":"4","author":"Kouhen","year":"2016","journal-title":"J. Health Sci."},{"key":"2026081714243607200_cit4","doi-asserted-by":"publisher","first-page":"98","DOI":"10.1373\/clinchem.2013.205740","article-title":"The emerging genomic landscape of\nendometrial cancer","volume":"60","author":"Le\nGallo","year":"2014","journal-title":"Clin. Chem."},{"key":"2026081714243607200_cit5","doi-asserted-by":"publisher","first-page":"277","DOI":"10.2217\/WHE.14.13","article-title":"Update on prognostic\nmarkers for endometrial cancer","volume":"10","author":"Binder","year":"2014","journal-title":"Womens Health\nLondon Engl."},{"key":"2026081714243607200_cit6","doi-asserted-by":"publisher","first-page":"205","DOI":"10.1053\/j.semdp.2014.03.002","article-title":"Updates in diagnostic\nimmunohistochemistry in endometrial\ncarcinoma","volume":"31","author":"Chiang","year":"2014","journal-title":"Semin. Diagn. Pathol."},{"key":"2026081714243607200_cit7","doi-asserted-by":"publisher","first-page":"383","DOI":"10.1097\/PAP.0000000000000046","article-title":"Endometrial stromal\ntumors: the new WHO classification","volume":"21","author":"Conklin","year":"2014","journal-title":"Adv. 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Proteome Res."},{"key":"2026081714243607200_cit25","doi-asserted-by":"publisher","first-page":"109536","DOI":"10.18632\/oncotarget.22725","article-title":"A proteomic approach\nfor the identification of biomarkers in endometrial\ncancer uterine aspirate","volume":"8","author":"Ura","year":"2017","journal-title":"Oncotarget"},{"key":"2026081714243607200_cit26","doi-asserted-by":"crossref","first-page":"60038","DOI":"10.18632\/oncotarget.11048","article-title":"Nucleophosmin\/B23 is\na negative regulator of estrogen receptor \u03b1\nexpression via AP2\u03b3 in endometrial cancer cells","volume":"7","author":"Lin","year":"2016","journal-title":"Oncotarget"},{"key":"2026081714243607200_cit27","doi-asserted-by":"publisher","first-page":"189","DOI":"10.3390\/ijms19010189","article-title":"3,3\u2032-Diindolylmethane\nSuppressed Cyprodinil-Induced Epithelial-Mesenchymal Transition and\nMetastatic-Related Behaviors of Human Endometrial Ishikawa Cells via\nan Estrogen Receptor-Dependent Pathway","volume":"19","author":"Kim","year":"2018","journal-title":"Int.\nJ. Mol. Sci."},{"key":"2026081714243607200_cit28","doi-asserted-by":"publisher","first-page":"638","DOI":"10.3109\/09513590.2013.777416","article-title":"Proteomic biomarkers\nof endometrial cancer risk in women with polycystic\novary syndrome: a systematic review and biomarker database integration","volume":"29","author":"Galazis","year":"2013","journal-title":"Gynecol. Endocrinol."},{"key":"2026081714243607200_cit29","doi-asserted-by":"publisher","first-page":"710","DOI":"10.1136\/jclinpath-2015-202915","article-title":"Immunohistochemical panel to differentiate endometrial\nstromal sarcoma,\nuterine leiomyosarcoma and leiomyoma: something old and something\nnew","volume":"68","author":"Hwang","year":"2015","journal-title":"J. Clin. Pathol."},{"key":"2026081714243607200_cit30","first-page":"308","article-title":"[Endometrial stromal\nsarcoma: morphologic features and detection\nof JAZF1-SUZ12 and YWHAE FAM22 fusion genes]","volume":"45","author":"Chang","year":"2016","journal-title":"Zhonghua Bing Li Xue Za Zhi"},{"key":"2026081714243607200_cit31","doi-asserted-by":"publisher","first-page":"349","DOI":"10.1007\/s00428-006-0345-8","article-title":"Extrauterine endometrial stromal sarcoma with JAZF1\/JJAZ1 fusion\nconfirmed by RT-PCR and interphase FISH presenting as an inguinal\ntumor","volume":"450","author":"Sato","year":"2007","journal-title":"Virchows Arch."},{"key":"2026081714243607200_cit32","first-page":"969","article-title":"Identification of Key\nCandidate Genes and Pathways in Endometrial\nCancer by Integrated Bioinformatical Analysis","volume":"19","author":"Liu","year":"2018","journal-title":"Asian Pac. J. Cancer Prev. APJCP"},{"key":"2026081714243607200_cit33","doi-asserted-by":"publisher","first-page":"42548","DOI":"10.18632\/oncotarget.17209","article-title":"Association of body\nmass index with ER, PR and 14\u20133-3\u03c3 expression in tumor\nand stroma of type I and type II endometrial carcinoma","volume":"8","author":"Peevey","year":"2017","journal-title":"Oncotarget"},{"key":"2026081714243607200_cit34","doi-asserted-by":"publisher","first-page":"455","DOI":"10.1016\/j.jmb.2008.08.048","article-title":"Crystal-structure and biochemical characterization\nof recombinant\nhuman calcyphosine delineates a novel EF-hand-containing protein family","volume":"383","author":"Dong","year":"2008","journal-title":"J. Mol. 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Biol."},{"key":"2026081714243607200_cit64","doi-asserted-by":"publisher","first-page":"1105","DOI":"10.1021\/acs.jproteome.6b00164","article-title":"Comprehensive Metaboproteomics of Burkitt\u2019s and Diffuse Large\nB-Cell Lymphoma Cell Lines and Primary Tumor Tissues Reveals Distinct\nDifferences in Pyruvate Content and Metabolism","volume":"16","author":"Schwarzfischer","year":"2017","journal-title":"J. Proteome Res."},{"key":"2026081714243607200_cit65","unstructured":"Sun, R.; \n               et al.\n          Accelerated Protein Biomarker Discovery from FFPE tissue samples\nusing Single-shot, Short Gradient Microflow SWATH MS. bioRxiv, 2019. http:\/\/biorxiv.org\/lookup\/doi\/10.1101\/675348. 10.1101\/675348."},{"key":"2026081714243607200_cit66","doi-asserted-by":"publisher","first-page":"477","DOI":"10.2147\/OTT.S92226","article-title":"Abnormal\nexpression of calcyphosine is associated with poor prognosis\nand cell biology function in colorectal cancer","author":"Xu","year":"2016","journal-title":"OncoTargets Ther."},{"key":"2026081714243607200_cit67","doi-asserted-by":"publisher","first-page":"8","DOI":"10.1186\/s12014-015-9080-y","article-title":"Proteomics profiling\nidentify CAPS as a potential predictive marker\nof tamoxifen resistance in estrogen receptor positive breast cancer","volume":"12","author":"Johansson","year":"2015","journal-title":"Clin. 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Med."},{"key":"2026081714243607200_cit71","doi-asserted-by":"publisher","first-page":"247","DOI":"10.1016\/j.ygyno.2017.05.017","article-title":"High stathmin expression\nis a marker for poor clinical outcome in\nendometrial cancer: An NRG oncology group\/gynecologic oncology group\nstudy","volume":"146","author":"Reyes","year":"2017","journal-title":"Gynecol. Oncol."},{"key":"2026081714243607200_cit72","doi-asserted-by":"publisher","first-page":"2331","DOI":"10.1158\/1078-0432.CCR-12-3413","article-title":"High phospho-Stathmin\u00ad(Serine38)\nexpression identifies aggressive\nendometrial cancer and suggests an association with PI3K inhibition","volume":"19","author":"Wik","year":"2013","journal-title":"Clin. Cancer Res."},{"key":"2026081714243607200_cit73","doi-asserted-by":"publisher","first-page":"565","DOI":"10.1530\/ERC-10-0046","article-title":"Changes in breast cancer biomarkers in the\nIGF1R\/PI3K pathway in\nrecurrent breast cancer after tamoxifen treatment","volume":"18","author":"Drury","year":"2011","journal-title":"Endocr.-Relat. Cancer"},{"key":"2026081714243607200_cit74","doi-asserted-by":"publisher","first-page":"317","DOI":"10.1007\/s10549-007-9724-3","article-title":"The prognostic value of Stathmin-1, S100A2, and SYK proteins in ER-positive\nprimary breast cancer patients treated with adjuvant tamoxifen monotherapy:\nan immunohistochemical study","volume":"110","author":"Golouh","year":"2008","journal-title":"Breast Cancer\nRes. Treat."},{"key":"2026081714243607200_cit75","doi-asserted-by":"publisher","first-page":"641","DOI":"10.1111\/j.1365-2559.2010.03661.x","article-title":"Stathmin is superior to AKT and phospho-AKT staining for the detection\nof phosphoinositide 3-kinase activation and aggressive endometrial\ncancer","volume":"57","author":"Trovik","year":"2010","journal-title":"Histopathology"},{"key":"2026081714243607200_cit76","doi-asserted-by":"publisher","first-page":"9951","DOI":"10.1007\/s13277-016-4869-5","article-title":"Elevated STMN1 promotes\ntumor growth and invasion in endometrial\ncarcinoma","volume":"37","author":"He","year":"2016","journal-title":"Tumor Biol."},{"key":"2026081714243607200_cit77","doi-asserted-by":"publisher","first-page":"403","DOI":"10.1007\/s11912-014-0403-3","article-title":"Current Status of\nMolecular Biomarkers in Endometrial\nCancer","volume":"16","author":"Werner","year":"2014","journal-title":"Curr. Oncol. Rep."},{"key":"2026081714243607200_cit78","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0090141","article-title":"Stathmin protein level, a potential predictive\nmarker\nfor taxane treatment response in endometrial cancer","volume":"9","author":"Werner","year":"2014","journal-title":"PLoS One"},{"key":"2026081714243607200_cit79","doi-asserted-by":"publisher","first-page":"3368","DOI":"10.1158\/1078-0432.CCR-10-2412","article-title":"Stathmin overexpression identifies high-risk patients\nand lymph node\nmetastasis in endometrial cancer","volume":"17","author":"Trovik","year":"2011","journal-title":"Clin. Cancer\nRes."},{"key":"2026081714243607200_cit80","doi-asserted-by":"publisher","first-page":"316","DOI":"10.1016\/j.ygyno.2012.07.105","article-title":"Clinico-pathologic comparison of type II endometrial cancers based\non tamoxifen exposure","volume":"127","author":"Tergas","year":"2012","journal-title":"Gynecol. Oncol."},{"key":"2026081714243607200_cit81","unstructured":"Human Protein\nAtlas; The Human Protein\nAtlas, 2020. http:\/\/www.proteinatlas.org."},{"key":"2026081714243607200_cit82","doi-asserted-by":"publisher","first-page":"1260419","DOI":"10.1126\/science.1260419","article-title":"Proteomics. Tissue-based\nmap of the human proteome","volume":"347","author":"Uhle\u0301n","year":"2015","journal-title":"Science"},{"key":"2026081714243607200_cit83","doi-asserted-by":"publisher","first-page":"1098","DOI":"10.1002\/bjs.10899","article-title":"Meta-analysis of the\ncumulative risk of endometrial malignancy and\nsystematic review of endometrial surveillance in extended tamoxifen\ntherapy","volume":"105","author":"Fleming","year":"2018","journal-title":"Br. J. Surg."},{"key":"2026081714243607200_cit84","unstructured":"Dus\u030cek, L.; \n               et al.\n          Epidemiology of Malignant Tumors in the Czech\nRepublic; Masaryk University, 2005. http:\/\/www.svod.cz."}],"container-title":["Journal of Proteome Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/pubs.acs.org\/doi\/pdf\/10.1021\/acs.jproteome.0c00064","content-type":"application\/pdf","content-version":"vor","intended-application":"unspecified"},{"URL":"https:\/\/pubs.acs.org\/jprobs\/article-pdf\/19\/7\/2617\/14422035\/pr0c00064.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/pubs.acs.org\/jprobs\/article-pdf\/19\/7\/2617\/14422035\/pr0c00064.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T18:34:00Z","timestamp":1786991640000},"score":1,"resource":{"primary":{"URL":"https:\/\/pubs.acs.org\/jprobs\/article\/19\/7\/2617\/1383520\/SWATH-MS-Analysis-of-FFPE-Tissues-Identifies"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,4,28]]},"references-count":84,"journal-issue":{"issue":"7","published-online":{"date-parts":[[2020,4,28]]},"published-print":{"date-parts":[[2020,7,2]]}},"URL":"https:\/\/doi.org\/10.1021\/acs.jproteome.0c00064","relation":{},"ISSN":["1535-3893","1535-3907"],"issn-type":[{"value":"1535-3893","type":"print"},{"value":"1535-3907","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,4,28]]}}}