{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T19:26:37Z","timestamp":1786994797742,"version":"build-2736575974"},"reference-count":16,"publisher":"American Chemical Society (ACS)","issue":"11","license":[{"start":{"date-parts":[[2020,8,14]],"date-time":"2020-08-14T00:00:00Z","timestamp":1597363200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2020,8,14]],"date-time":"2020-08-14T00:00:00Z","timestamp":1597363200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2020,8,14]],"date-time":"2020-08-14T00:00:00Z","timestamp":1597363200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-045"}],"funder":[{"DOI":"10.13039\/501100004564","name":"Ministarstvo Prosvete, Nauke i Tehnolo?kog Razvoja","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004564","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2020,11,6]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>The Bacillus Calmette\u2013Guerin vaccine is still widely used in the developing world. The vaccination prevents infant death not only from tuberculosis but also from unrelated infectious agents, especially respiratory tract infections and neonatal sepsis. It is proposed that these off-target protective effects of the BCG vaccine are mediated by the general long-term boosting of innate immune mechanisms, also termed \u201ctrained innate immunity\u201d. Recent studies indicate that both COVID-19 incidence and total deaths are strongly associated with the presence or absence of national mandatory BCG vaccination programs and encourage the initiation of several clinical studies with the expectation that revaccination with BCG could reduce the incidence and severity of COVID-19. Here, presented results from the bioinformatics analysis of the Mycobacterium bovis (strain BCG\/Pasteur 1173P2) proteome suggests four immunodominant antigens that could induce an immune response against SARS-CoV-2.<\/jats:p>","DOI":"10.1021\/acs.jproteome.0c00410","type":"journal-article","created":{"date-parts":[[2020,8,14]],"date-time":"2020-08-14T14:30:54Z","timestamp":1597415454000},"page":"4649-4654","source":"Crossref","is-referenced-by-count":12,"title":["Biological Rationale for the Repurposing of BCG Vaccine against SARS-CoV\u20112"],"prefix":"10.1021","volume":"19","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5691-1055","authenticated-orcid":true,"given":"Sanja","family":"Glisic","sequence":"first","affiliation":[{"name":"University of Belgrade , , ,","place":["Belgrade, Serbia, 11001"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vladimir R.","family":"Perovic","sequence":"additional","affiliation":[{"name":"University of Belgrade , , ,","place":["Belgrade, Serbia, 11001"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Milan","family":"Sencanski","sequence":"additional","affiliation":[{"name":"University of Belgrade , , ,","place":["Belgrade, Serbia, 11001"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Slobodan","family":"Paessler","sequence":"additional","affiliation":[{"name":"University of Texas Medical Branch , , , ,","place":["Galveston, Texas, United States, 77555"]},{"name":"University of Texas Medical Branch , , , ,","place":["Galveston, Texas, United States, 77555"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Veljko","family":"Veljkovic","sequence":"additional","affiliation":[{"name":"Biomed Protection , , ,","place":["Galveston, Texas, United States, 77550"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"316","published-online":{"date-parts":[[2020,8,14]]},"reference":[{"key":"2026081714253659200_cit1","unstructured":"WHO - Draft landscape of COVID-19 candidate vaccines. https:\/\/www.who.int\/who-documents-detail\/draft-landscape-of-covid-19-candidate-vaccines (accessed 2020-06-01)."},{"key":"2026081714253659200_cit2","doi-asserted-by":"publisher","DOI":"10.1101\/2020.03.24.20042937","article-title":"Correlation\nbetween universal BCG vaccination policy and reduced morbidity and\nmortality for COVID-19: an epidemiological study","author":"Miller","year":"2020","journal-title":"MedRxiv preprint"},{"key":"2026081714253659200_cit3","doi-asserted-by":"publisher","first-page":"i5170","DOI":"10.1136\/bmj.i5170","article-title":"Association of BCG,\nDTP, and measles containing vaccines with childhood mortality: systematic\nreview","volume":"355","author":"Higgins","year":"2016","journal-title":"BMJ."},{"key":"2026081714253659200_cit4","doi-asserted-by":"publisher","first-page":"335","DOI":"10.1038\/s41577-020-0337-y","article-title":"BCG- induced trained immunity: can it offer protection\nagainst COVID-19?","volume":"20","author":"O\u2019Neill","year":"2020","journal-title":"Nat. Rev. Immunol."},{"key":"2026081714253659200_cit5","doi-asserted-by":"publisher","first-page":"158","DOI":"10.1034\/j.1399-3011.2003.00081.x","article-title":"Design of\npeptide mimetics of HIV-1 gp120 for prevention and therapy of HIV\ndisease","volume":"62","author":"Veljkovic","year":"2003","journal-title":"J. Pept. Res."},{"key":"2026081714253659200_cit6","doi-asserted-by":"publisher","first-page":"1882","DOI":"10.1038\/s41598-018-20185-8","article-title":"Zika virus infection elicits auto-antibodies to C1q","volume":"8","author":"Koma","year":"2018","journal-title":"Sci. Rep."},{"key":"2026081714253659200_cit7","doi-asserted-by":"publisher","first-page":"337","DOI":"10.1109\/TBME.1985.325549","article-title":"Is it possible to analyze DNA and protein sequence\nby the method of digital signal processing?","volume":"BME-32","author":"Veljkovic","year":"1985","journal-title":"IEEE Trans. Biomed. Eng."},{"key":"2026081714253659200_cit8","first-page":"139","article-title":"A novel method of protein analysis\nfor prediction of biological function","volume":"9","author":"Veljkovic","year":"1987","journal-title":"Cancer\nBiochem. Biophys."},{"key":"2026081714253659200_cit9","doi-asserted-by":"publisher","first-page":"105","DOI":"10.1103\/PhysRevLett.29.105","article-title":"Simple general-model pseudopotential","volume":"29","author":"Veljkovic","year":"1972","journal-title":"Phys. Rev. Lett."},{"key":"2026081714253659200_cit10","doi-asserted-by":"publisher","first-page":"41","DOI":"10.1016\/0375-9601(73)90497-0","article-title":"The dependence of the Fermi energy on the atomic number","volume":"45A","author":"Veljkovic","year":"1973","journal-title":"Phys. Lett. A"},{"key":"2026081714253659200_cit11","doi-asserted-by":"publisher","first-page":"17720","DOI":"10.1073\/pnas.2008410117","article-title":"BCG vaccine\nprotection from severe coronavirus disease 2019 (COVID-19)","volume":"117","author":"Escobar","year":"2020","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"2026081714253659200_cit12","doi-asserted-by":"publisher","first-page":"449","DOI":"10.1046\/j.1365-3083.2003.01321.x","article-title":"Modulation of Host Immune Responses\nby Overexpression of Immunodominant Antigens of Mycobacterium tuberculosis\nin Bacille Calmette\u2013Gue\u0301rin","volume":"58","author":"Rao","year":"2003","journal-title":"Scand.\nJ. Immunol."},{"key":"2026081714253659200_cit13","doi-asserted-by":"publisher","first-page":"52","DOI":"10.12688\/f1000research.22149.2","article-title":"Use of the informational\nspectrum methodology for rapid biological analysis of the novel coronavirus\n2019-CoV: prediction of potential receptor, natural reservoir, tropism\nand therapeutic\/vaccine target","volume":"9","author":"Veljkovic","year":"2020","journal-title":"F1000Research"},{"key":"2026081714253659200_cit14","unstructured":"MtbVeb - A web portal for M. tuberculosis vaccine. http:\/\/crdd.osdd.net\/raghava\/mtbveb\/ (accessed 2020-06-01)."},{"key":"2026081714253659200_cit15","unstructured":"NIAID - The Immune\nEpitope Database. https:\/\/www.iedb.org\/ (accessed 2020-06-01)."},{"key":"2026081714253659200_cit16","doi-asserted-by":"publisher","first-page":"e1004671","DOI":"10.1371\/journal.ppat.1004671","article-title":"Human CD8+ T-cells Recognizing Peptides\nfrom Mycobacterium tuberculosis (Mtb) Presented by HLA-E Have an Unorthodox\nTh2-like, Multifunctional, Mtb Inhibitory Phenotype and Represent\na Novel Human T-cell Subset","volume":"11","author":"van\nMeijgaarden","year":"2015","journal-title":"PLoS Pathog."}],"container-title":["Journal of Proteome Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/pubs.acs.org\/doi\/pdf\/10.1021\/acs.jproteome.0c00410","content-type":"application\/pdf","content-version":"vor","intended-application":"unspecified"},{"URL":"https:\/\/pubs.acs.org\/jprobs\/article-pdf\/19\/11\/4649\/14423452\/pr0c00410.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/pubs.acs.org\/jprobs\/article-pdf\/19\/11\/4649\/14423452\/pr0c00410.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T18:31:44Z","timestamp":1786991504000},"score":1,"resource":{"primary":{"URL":"https:\/\/pubs.acs.org\/jprobs\/article\/19\/11\/4649\/1383622\/Biological-Rationale-for-the-Repurposing-of-BCG"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,8,14]]},"references-count":16,"journal-issue":{"issue":"11","published-online":{"date-parts":[[2020,8,14]]},"published-print":{"date-parts":[[2020,11,6]]}},"URL":"https:\/\/doi.org\/10.1021\/acs.jproteome.0c00410","relation":{},"ISSN":["1535-3893","1535-3907"],"issn-type":[{"value":"1535-3893","type":"print"},{"value":"1535-3907","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,8,14]]}}}