{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T16:18:47Z","timestamp":1788279527472,"version":"build-2803163510"},"reference-count":153,"publisher":"American Chemical Society (ACS)","issue":"11","license":[{"start":{"date-parts":[[2020,9,21]],"date-time":"2020-09-21T00:00:00Z","timestamp":1600646400000},"content-version":"vor","delay-in-days":16,"URL":"https:\/\/pubs.acs.org\/page\/policy\/authorchoice_ccby_termsofuse.html"}],"funder":[{"DOI":"10.13039\/501100002347","name":"Bundesministerium f\u00fcr Bildung und Forschung","doi-asserted-by":"publisher","award":["13XP5050A"],"award-info":[{"award-number":["13XP5050A"]}],"id":[{"id":"10.13039\/501100002347","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004189","name":"Max-Planck-Gesellschaft","doi-asserted-by":"publisher","award":["NA"],"award-info":[{"award-number":["NA"]}],"id":[{"id":"10.13039\/501100004189","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/na","name":"Fraunhofer-Max Planck cooperation project","doi-asserted-by":"publisher","award":["NA"],"award-info":[{"award-number":["NA"]}],"id":[{"id":"10.13039\/na","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2020,11,6]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Emergence and re-emergence of pathogens bearing the risk of becoming a pandemic threat are on the rise. Increased travel and trade, growing population density, changes in urbanization, and climate have a critical impact on infectious disease spread. Currently, the world is confronted with the emergence of a novel coronavirus SARS-CoV-2, responsible for yet more than 800\u202f000 deaths globally. Outbreaks caused by viruses, such as SARS-CoV-2, HIV, Ebola, influenza, and Zika, have increased over the past decade, underlining the need for a rapid development of diagnostics and vaccines. Hence, the rational identification of biomarkers for diagnostic measures on the one hand, and antigenic targets for vaccine development on the other, are of utmost importance. Peptide microarrays can display large numbers of putative target proteins translated into overlapping linear (and cyclic) peptides for a multiplexed, high-throughput antibody analysis. This enabled for example the identification of discriminant\/diagnostic epitopes in Zika or influenza and mapping epitope evolution in natural infections versus vaccinations. In this review, we highlight synthesis platforms that facilitate fast and flexible generation of high-density peptide microarrays. We further outline the multifaceted applications of these peptide array platforms for the development of serological tests and vaccines to quickly encounter pandemic threats.<\/jats:p>","DOI":"10.1021\/acs.jproteome.0c00484","type":"journal-article","created":{"date-parts":[[2020,9,5]],"date-time":"2020-09-05T11:48:15Z","timestamp":1599306495000},"page":"4339-4354","source":"Crossref","is-referenced-by-count":32,"title":["Rapid Response\nto Pandemic Threats: Immunogenic Epitope\nDetection of Pandemic Pathogens for Diagnostics and Vaccine Development\nUsing Peptide Microarrays"],"prefix":"10.1021","volume":"19","author":[{"given":"Kirsten","family":"Heiss","sequence":"first","affiliation":[{"name":"PEPperPRINT GmbH , Rischerstrasse 12 , ,","place":["Heidelberg, Germany, 69123"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jasmin","family":"Heidepriem","sequence":"additional","affiliation":[{"name":"Max Planck Institute of Colloids and Interfaces , , Am Muehlenberg 1 , ,","place":["Potsdam, Germany, 14476"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nico","family":"Fischer","sequence":"additional","affiliation":[{"name":"Heidelberg University Hospital , , INF 324 , ,","place":["Heidelberg, Germany, 69120"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laura K.","family":"Weber","sequence":"additional","affiliation":[{"name":"PEPperPRINT GmbH , Rischerstrasse 12 , ,","place":["Heidelberg, Germany, 69123"]},{"name":"Karlsruhe Institute of Technology , , Hermann-von-Helmholtz-Platz 1 , ,","place":["Eggenstein-Leopoldshafen, Germany, 76344"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christine","family":"Dahlke","sequence":"additional","affiliation":[{"name":"University Medical Center Hamburg-Eppendorf , , ,","place":["Hamburg, Germany, 20246"]},{"name":"Bernhard Nocht Institute for Tropical Medicine , , ,","place":["Hamburg, Germany, 20359"]},{"name":"German Center for Infection Research , , ,","place":["Braunschweig, Germany, 38124"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas","family":"Jaenisch","sequence":"additional","affiliation":[{"name":"Heidelberg University Hospital , , Im Neuenheimer Feld 130 , ,","place":["Heidelberg, Germany, 69120"]},{"name":"University of Colorado , , , ,","place":["Aurora, Colorado, United States, 80045"]},{"name":"University of Colorado , , , ,","place":["Aurora, Colorado, United States, 80045"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8227-2522","authenticated-orcid":true,"given":"Felix F.","family":"Loeffler","sequence":"additional","affiliation":[{"name":"Max Planck Institute of Colloids and Interfaces , , Am Muehlenberg 1 , ,","place":["Potsdam, Germany, 14476"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"316","published-online":{"date-parts":[[2020,9,5]]},"reference":[{"key":"2026090111333805100_cit1","doi-asserted-by":"publisher","DOI":"10.1596\/978-1-4648-0527-1_ch17","article-title":"Pandemics: Risks, Impacts, and Mitigation","volume-title":"Disease Control Priorities: Improving Health and Reducing\nPoverty","author":"Madhav","year":"2017"},{"key":"2026090111333805100_cit2","unstructured":"Johns Hopkins University.\n          . https:\/\/coronavirus.jhu.edu\/map.html (accessed April 9, 2020)."},{"issue":"5","key":"2026090111333805100_cit3","doi-asserted-by":"publisher","first-page":"533","DOI":"10.1016\/S1473-3099(20)30120-1","article-title":"An interactive web-based dashboard to track COVID-19\nin real time","volume":"20","author":"Dong","year":"2020","journal-title":"Lancet Infect. 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