{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,9]],"date-time":"2026-04-09T01:02:39Z","timestamp":1775696559926,"version":"3.50.1"},"reference-count":63,"publisher":"American Chemical Society (ACS)","issue":"4","license":[{"start":{"date-parts":[[2022,3,9]],"date-time":"2022-03-09T00:00:00Z","timestamp":1646784000000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001648","name":"European Foundation for the Study of Diabetes","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001648","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001871","name":"Minist??rio da Educa????o e Ci??ncia","doi-asserted-by":"publisher","award":["PD\/BD\/114044\/2015"],"award-info":[{"award-number":["PD\/BD\/114044\/2015"]}],"id":[{"id":"10.13039\/501100001871","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001871","name":"Minist??rio da Educa????o e Ci??ncia","doi-asserted-by":"publisher","award":["PTDC\/MEC-MET\/29314\/2017"],"award-info":[{"award-number":["PTDC\/MEC-MET\/29314\/2017"]}],"id":[{"id":"10.13039\/501100001871","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001871","name":"Minist??rio da Educa????o e Ci??ncia","doi-asserted-by":"publisher","award":["UIDB\/Multi\/04462\/2020"],"award-info":[{"award-number":["UIDB\/Multi\/04462\/2020"]}],"id":[{"id":"10.13039\/501100001871","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Programa Gilead G???NESE"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J. Proteome Res."],"published-print":{"date-parts":[[2022,4,1]]},"DOI":"10.1021\/acs.jproteome.1c00353","type":"journal-article","created":{"date-parts":[[2022,3,9]],"date-time":"2022-03-09T19:43:16Z","timestamp":1646854996000},"page":"910-920","source":"Crossref","is-referenced-by-count":11,"title":["Messages from the Small Intestine Carried by Extracellular Vesicles in Prediabetes: A Proteomic Portrait"],"prefix":"10.1021","volume":"21","author":[{"given":"In\u00eas","family":"Ferreira","sequence":"first","affiliation":[{"name":"Chronic Diseases Research Centre, CEDOC, NOVA Medical School, (NMS\/FCM), Lisbon 1169-056, Portugal"},{"name":"Bioengineering\u2500Cell Therapies and Regenerative Medicine PhD Program, Instituto Superior T\u00e9cnico, University of Lisbon, Lisbon 1049-001, Portugal"},{"name":"Champalimaud Research, Champalimaud Centre for the Unknown, 1400-038 Lisbon, Portugal"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0970-4501","authenticated-orcid":true,"given":"Rita","family":"Machado de Oliveira","sequence":"additional","affiliation":[{"name":"Chronic Diseases Research Centre, CEDOC, NOVA Medical School, (NMS\/FCM), Lisbon 1169-056, Portugal"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ana Sofia","family":"Carvalho","sequence":"additional","affiliation":[{"name":"Chronic Diseases Research Centre, CEDOC, NOVA Medical School, (NMS\/FCM), Lisbon 1169-056, Portugal"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Akiko","family":"Teshima","sequence":"additional","affiliation":[{"name":"Chronic Diseases Research Centre, CEDOC, NOVA Medical School, (NMS\/FCM), Lisbon 1169-056, Portugal"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hans Christian","family":"Beck","sequence":"additional","affiliation":[{"name":"Centre for Clinical Proteomics, Department of Clinical Biochemistry and Pharmacology, Odense University Hospital, Odense 5000, Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6353-2616","authenticated-orcid":true,"given":"Rune","family":"Matthiesen","sequence":"additional","affiliation":[{"name":"Chronic Diseases Research Centre, CEDOC, NOVA Medical School, (NMS\/FCM), Lisbon 1169-056, Portugal"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bruno","family":"Costa-Silva","sequence":"additional","affiliation":[{"name":"Champalimaud Research, Champalimaud Centre for the Unknown, 1400-038 Lisbon, Portugal"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maria Paula","family":"Macedo","sequence":"additional","affiliation":[{"name":"Chronic Diseases Research Centre, CEDOC, NOVA Medical School, (NMS\/FCM), Lisbon 1169-056, Portugal"},{"name":"APDP-ERC Portuguese Diabetes Association Education and Research Centre, Lisbon 1250-189, Portugal"},{"name":"Departament of Medical Sciences, University of Aveiro, Aveiro 3810-193, Portugal"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"316","published-online":{"date-parts":[[2022,3,9]]},"reference":[{"key":"ref1\/cit1","unstructured":"IDF.\n                      IDF Diabetes Atlas\n                      , 9th ed. IDF, 2019; p 168."},{"key":"ref2\/cit2","doi-asserted-by":"publisher","DOI":"10.2337\/dc16-0236"},{"key":"ref3\/cit3","doi-asserted-by":"publisher","DOI":"10.2337\/dc19-1057"},{"key":"ref4\/cit4","doi-asserted-by":"publisher","DOI":"10.1152\/physrev.00063.2017"},{"key":"ref5\/cit5","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(12)60283-9"},{"key":"ref6\/cit6","doi-asserted-by":"publisher","DOI":"10.1007\/s11892-018-1103-4"},{"key":"ref7\/cit7","doi-asserted-by":"publisher","DOI":"10.1152\/ajpcell.00536.2019"},{"key":"ref8\/cit8","doi-asserted-by":"publisher","DOI":"10.1016\/j.gpb.2015.02.001"},{"key":"ref9\/cit9","doi-asserted-by":"publisher","DOI":"10.1038\/nri855"},{"key":"ref10\/cit10","doi-asserted-by":"publisher","DOI":"10.2337\/db09-0216"},{"key":"ref11\/cit11","doi-asserted-by":"publisher","DOI":"10.1002\/oby.20847"},{"key":"ref12\/cit12","doi-asserted-by":"publisher","DOI":"10.1002\/hep4.1556"},{"key":"ref13\/cit13","doi-asserted-by":"publisher","DOI":"10.1155\/2020\/1945832"},{"key":"ref14\/cit14","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2014.00104"},{"key":"ref15\/cit15","doi-asserted-by":"publisher","DOI":"10.1371\/journal.ppat.1003261"},{"key":"ref16\/cit16","doi-asserted-by":"publisher","DOI":"10.1038\/emm.2017.282"},{"key":"ref17\/cit17","doi-asserted-by":"publisher","DOI":"10.1016\/j.bcmd.2005.04.001"},{"key":"ref18\/cit18","doi-asserted-by":"publisher","DOI":"10.1146\/annurev-physiol-022516-034423"},{"key":"ref19\/cit19","doi-asserted-by":"publisher","DOI":"10.4103\/2230-8210.163113"},{"key":"ref20\/cit20","doi-asserted-by":"publisher","DOI":"10.1038\/nature12820"},{"key":"ref21\/cit21","doi-asserted-by":"publisher","DOI":"10.1007\/s00592-011-0333-6"},{"key":"ref22\/cit22","doi-asserted-by":"publisher","DOI":"10.1152\/ajpendo.00165.2014"},{"key":"ref23\/cit23","doi-asserted-by":"publisher","DOI":"10.3390\/ijms17020170"},{"key":"ref24\/cit24","doi-asserted-by":"publisher","DOI":"10.1038\/nature10098"},{"key":"ref25\/cit25","doi-asserted-by":"publisher","DOI":"10.1152\/physrev.00019.2011"},{"key":"ref26\/cit26","doi-asserted-by":"publisher","DOI":"10.1016\/s0021-9258(20)81311-8"},{"key":"ref27\/cit27","doi-asserted-by":"publisher","DOI":"10.1016\/s0021-9258(18)50934-0"},{"key":"ref28\/cit28","doi-asserted-by":"publisher","DOI":"10.1016\/s0021-9258(18)65496-1"},{"key":"ref29\/cit29","doi-asserted-by":"publisher","DOI":"10.1002\/iub.1063"},{"key":"ref30\/cit30","doi-asserted-by":"publisher","DOI":"10.1016\/s0140-6736(63)91500-9"},{"key":"ref31\/cit31","doi-asserted-by":"publisher","DOI":"10.2337\/diabetes.49.5.677"},{"key":"ref32\/cit32","doi-asserted-by":"publisher","DOI":"10.1039\/c8fo02578a"},{"key":"ref33\/cit33","doi-asserted-by":"publisher","DOI":"10.1097\/mco.0000000000000569"},{"key":"ref34\/cit34","doi-asserted-by":"publisher","DOI":"10.1016\/j.cmet.2021.09.004"},{"key":"ref35\/cit35","doi-asserted-by":"publisher","DOI":"10.1016\/j.cmet.2021.09.010"},{"key":"ref36\/cit36","doi-asserted-by":"publisher","DOI":"10.1016\/j.ymben.2019.08.018"},{"key":"ref37\/cit37","doi-asserted-by":"publisher","DOI":"10.1152\/ajpendo.00185.2012"},{"key":"ref38\/cit38","doi-asserted-by":"publisher","DOI":"10.3390\/jcm10040596"},{"key":"ref39\/cit39","doi-asserted-by":"publisher","DOI":"10.1016\/j.cmet.2017.12.016"},{"key":"ref40\/cit40","doi-asserted-by":"publisher","DOI":"10.3390\/ijms20205039"},{"key":"ref41\/cit41","doi-asserted-by":"publisher","DOI":"10.1074\/mcp.m900020-mcp200"},{"key":"ref42\/cit42","doi-asserted-by":"publisher","DOI":"10.1080\/10715762.2018.1453136"},{"key":"ref43\/cit43","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbalip.2015.03.003"},{"key":"ref44\/cit44","doi-asserted-by":"publisher","DOI":"10.1016\/j.humpath.2018.03.013"},{"key":"ref45\/cit45","doi-asserted-by":"publisher","DOI":"10.1002\/hep.31409"},{"key":"ref46\/cit46","doi-asserted-by":"publisher","DOI":"10.1002\/hep.30411"},{"key":"ref48\/cit48","doi-asserted-by":"publisher","DOI":"10.1002\/hep.21655"},{"key":"ref49\/cit49","doi-asserted-by":"publisher","DOI":"10.1248\/bpb.34.87"},{"key":"ref50\/cit50","doi-asserted-by":"publisher","DOI":"10.2337\/db16-1519"},{"key":"ref51\/cit51","doi-asserted-by":"publisher","DOI":"10.1038\/s41419-017-0135-z"},{"key":"ref52\/cit52","doi-asserted-by":"publisher","DOI":"10.1038\/s41573-021-00233-1"},{"key":"ref53\/cit53","doi-asserted-by":"publisher","DOI":"10.1080\/03602532.2018.1555587"},{"key":"ref54\/cit54","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0182208"},{"key":"ref55\/cit55","doi-asserted-by":"publisher","DOI":"10.1152\/physrev.00017.2013"},{"key":"ref56\/cit56","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.200371497"},{"key":"ref57\/cit57","doi-asserted-by":"publisher","DOI":"10.1016\/j.jbior.2015.09.008"},{"key":"ref58\/cit58","doi-asserted-by":"publisher","DOI":"10.1093\/jn\/109.1.24"},{"key":"ref59\/cit59","doi-asserted-by":"publisher","DOI":"10.3945\/ajcn.2008.26362"},{"key":"ref60\/cit60","doi-asserted-by":"publisher","DOI":"10.1152\/physrev.00034.2006"},{"key":"ref61\/cit61","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2007.03.054"},{"key":"ref62\/cit62","doi-asserted-by":"publisher","DOI":"10.1038\/s41580-018-0040-z"},{"key":"ref63\/cit63","doi-asserted-by":"publisher","DOI":"10.1038\/nbt.1511"},{"key":"ref64\/cit64","doi-asserted-by":"publisher","DOI":"10.1074\/mcp.m113.034363"}],"container-title":["Journal of Proteome Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/pubs.acs.org\/doi\/pdf\/10.1021\/acs.jproteome.1c00353","content-type":"application\/pdf","content-version":"vor","intended-application":"unspecified"},{"URL":"https:\/\/pubs.acs.org\/doi\/pdf\/10.1021\/acs.jproteome.1c00353","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,4,27]],"date-time":"2023-04-27T16:04:54Z","timestamp":1682611494000},"score":1,"resource":{"primary":{"URL":"https:\/\/pubs.acs.org\/doi\/10.1021\/acs.jproteome.1c00353"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,3,9]]},"references-count":63,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2022,4,1]]}},"alternative-id":["10.1021\/acs.jproteome.1c00353"],"URL":"https:\/\/doi.org\/10.1021\/acs.jproteome.1c00353","relation":{"has-preprint":[{"id-type":"doi","id":"10.1101\/2021.02.19.431856","asserted-by":"object"}]},"ISSN":["1535-3893","1535-3907"],"issn-type":[{"value":"1535-3893","type":"print"},{"value":"1535-3907","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,3,9]]}}}