{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,14]],"date-time":"2026-07-14T22:59:36Z","timestamp":1784069976529,"version":"3.55.0"},"reference-count":70,"publisher":"American Chemical Society (ACS)","issue":"8","license":[{"start":{"date-parts":[[2024,4,10]],"date-time":"2024-04-10T00:00:00Z","timestamp":1712707200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/100008061","name":"Fundaci?n Mutua Madrile?a","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100008061","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100012818","name":"Comunidad de Madrid","doi-asserted-by":"publisher","award":["2018-T2\/BMD-11561"],"award-info":[{"award-number":["2018-T2\/BMD-11561"]}],"id":[{"id":"10.13039\/100012818","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100012818","name":"Comunidad de Madrid","doi-asserted-by":"publisher","award":["PEJ-2020-AI\/BMD-17899"],"award-info":[{"award-number":["PEJ-2020-AI\/BMD-17899"]}],"id":[{"id":"10.13039\/100012818","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100012818","name":"Comunidad de Madrid","doi-asserted-by":"publisher","award":["PEJD-2019-PRE\/BMD-16992"],"award-info":[{"award-number":["PEJD-2019-PRE\/BMD-16992"]}],"id":[{"id":"10.13039\/100012818","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100012818","name":"Comunidad de Madrid","doi-asserted-by":"publisher","award":["PIPF-2022\/SAL-GL 25760"],"award-info":[{"award-number":["PIPF-2022\/SAL-GL 25760"]}],"id":[{"id":"10.13039\/100012818","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100014440","name":"Ministerio de Ciencia, Innovaci?n y Universidades","doi-asserted-by":"publisher","award":["PGC2018-097019-B-I00"],"award-info":[{"award-number":["PGC2018-097019-B-I00"]}],"id":[{"id":"10.13039\/100014440","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100014440","name":"Ministerio de Ciencia, Innovaci?n y Universidades","doi-asserted-by":"publisher","award":["PID2021-122348NB-I00"],"award-info":[{"award-number":["PID2021-122348NB-I00"]}],"id":[{"id":"10.13039\/100014440","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100010434","name":"'la Caixa' Foundation","doi-asserted-by":"publisher","award":["HR17-00247"],"award-info":[{"award-number":["HR17-00247"]}],"id":[{"id":"10.13039\/100010434","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100010434","name":"'la Caixa' Foundation","doi-asserted-by":"publisher","award":["HR22-00253"],"award-info":[{"award-number":["HR22-00253"]}],"id":[{"id":"10.13039\/100010434","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100012006","name":"Fundaci?n Conchita R?bago","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100012006","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Getinge Group Spain SL"},{"name":"Instituto de Salud Carlos III with co-funding from the ERDF","award":["CP22\/00100"],"award-info":[{"award-number":["CP22\/00100"]}]},{"name":"Instituto de Salud Carlos III with co-funding from the ERDF","award":["FI21\/00128"],"award-info":[{"award-number":["FI21\/00128"]}]},{"name":"Instituto de Salud Carlos III with co-funding from the ERDF","award":["IF08\/3667-1"],"award-info":[{"award-number":["IF08\/3667-1"]}]},{"name":"Instituto de Salud Carlos III with co-funding from the ERDF","award":["PI20\/01103"],"award-info":[{"award-number":["PI20\/01103"]}]},{"name":"Instituto de Salud Carlos III with co-funding from the ERDF","award":["PI21\/00158"],"award-info":[{"award-number":["PI21\/00158"]}]},{"name":"Instituto de Salud Carlos III with co-funding from the ERDF","award":["PRB3[IPT17\/0019-ISCIII-SGEFI\/ERDF]"],"award-info":[{"award-number":["PRB3[IPT17\/0019-ISCIII-SGEFI\/ERDF]"]}]},{"name":"Instituto de Salud Carlos III with co-funding from the ERDF","award":["RD16\/0009"],"award-info":[{"award-number":["RD16\/0009"]}]},{"name":"Instituto de Salud Carlos III with co-funding from the ERDF","award":["RD21\/0005\/0001"],"award-info":[{"award-number":["RD21\/0005\/0001"]}]},{"name":"Sociedad Espa?ola de Nefrolog?a-Foundation SENEFRO"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J. Proteome Res."],"published-print":{"date-parts":[[2024,8,2]]},"DOI":"10.1021\/acs.jproteome.3c00649","type":"journal-article","created":{"date-parts":[[2024,4,10]],"date-time":"2024-04-10T04:17:22Z","timestamp":1712722642000},"page":"3012-3024","source":"Crossref","is-referenced-by-count":9,"title":["Analysis of Vascular Smooth Muscle Cells from Thoracic Aortic Aneurysms Reveals DNA Damage and Cell Cycle Arrest as Hallmarks in Bicuspid Aortic Valve Patients"],"prefix":"10.1021","volume":"23","author":[{"given":"Ariadna","family":"Martin-Blazquez","sequence":"first","affiliation":[{"name":"Immunology Department, IIS-Fundaci\u00f3n Jim\u00e9nez D\u00edaz, Fundaci\u00f3n Jim\u00e9nez D\u00edaz Hospital-UAM, 28040 Madrid, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marta","family":"Martin-Lorenzo","sequence":"additional","affiliation":[{"name":"Immunology Department, IIS-Fundaci\u00f3n Jim\u00e9nez D\u00edaz, Fundaci\u00f3n Jim\u00e9nez D\u00edaz Hospital-UAM, 28040 Madrid, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aranzazu","family":"Santiago-Hernandez","sequence":"additional","affiliation":[{"name":"Immunology Department, IIS-Fundaci\u00f3n Jim\u00e9nez D\u00edaz, Fundaci\u00f3n Jim\u00e9nez D\u00edaz Hospital-UAM, 28040 Madrid, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Angeles","family":"Heredero","sequence":"additional","affiliation":[{"name":"Cardiac Surgery Service, Fundaci\u00f3n Jim\u00e9nez D\u00edaz Hospital-UAM, 28040 Madrid, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alicia","family":"Donado","sequence":"additional","affiliation":[{"name":"Cardiac Surgery Service, Fundaci\u00f3n Jim\u00e9nez D\u00edaz Hospital-UAM, 28040 Madrid, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Juan A","family":"Lopez","sequence":"additional","affiliation":[{"name":"Laboratory of Cardiovascular Proteomics, Centro Nacional de Investigaciones Cardiovasculares (CNIC), 28029 Madrid, Spain"},{"name":"CIBER de Enfermedades Cardiovasculares (CIBERCV), 28029 Madrid, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Miriam","family":"Anfaiha-Sanchez","sequence":"additional","affiliation":[{"name":"Immunology Department, IIS-Fundaci\u00f3n Jim\u00e9nez D\u00edaz, Fundaci\u00f3n Jim\u00e9nez D\u00edaz Hospital-UAM, 28040 Madrid, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rocio","family":"Ruiz-Jimenez","sequence":"additional","affiliation":[{"name":"Immunology Department, IIS-Fundaci\u00f3n Jim\u00e9nez D\u00edaz, Fundaci\u00f3n Jim\u00e9nez D\u00edaz Hospital-UAM, 28040 Madrid, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vanesa","family":"Esteban","sequence":"additional","affiliation":[{"name":"Department of Allergy and Immunology, IIS-Fundaci\u00f3n Jim\u00e9nez D\u00edaz, Fundaci\u00f3n Jim\u00e9nez D\u00edaz Hospital-UAM, 28040 Madrid, Spain"},{"name":"Faculty of Medicine and Biomedicine, Alfonso X El Sabio University, 28691 Madrid, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jesus","family":"Vazquez","sequence":"additional","affiliation":[{"name":"Laboratory of Cardiovascular Proteomics, Centro Nacional de Investigaciones Cardiovasculares (CNIC), 28029 Madrid, Spain"},{"name":"CIBER de Enfermedades Cardiovasculares (CIBERCV), 28029 Madrid, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gonzalo","family":"Aldamiz-Echevarria","sequence":"additional","affiliation":[{"name":"Cardiac Surgery Service, Fundaci\u00f3n Jim\u00e9nez D\u00edaz Hospital-UAM, 28040 Madrid, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3313-721X","authenticated-orcid":true,"given":"Gloria","family":"Alvarez-Llamas","sequence":"additional","affiliation":[{"name":"Immunology Department, IIS-Fundaci\u00f3n Jim\u00e9nez D\u00edaz, Fundaci\u00f3n Jim\u00e9nez D\u00edaz Hospital-UAM, 28040 Madrid, Spain"},{"name":"RICORS2040, Fundaci\u00f3n Jim\u00e9nez D\u00edaz, 28040 Madrid, Spain"},{"name":"Department of Biochemistry and Molecular Biology, Complutense University, 28040 Madrid, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"316","published-online":{"date-parts":[[2024,4,10]]},"reference":[{"key":"ref1\/cit1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCRESAHA.118.312436"},{"key":"ref2\/cit2","doi-asserted-by":"publisher","DOI":"10.1007\/s11748-017-0874-x"},{"key":"ref3\/cit3","doi-asserted-by":"publisher","DOI":"10.1002\/path.5683"},{"key":"ref4\/cit4","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMra1207059"},{"key":"ref5\/cit5","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2011.1286"},{"key":"ref6\/cit6","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.119.043756"},{"key":"ref7\/cit7","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.120.051171"},{"key":"ref8\/cit8","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.118.035648"},{"key":"ref9\/cit9","doi-asserted-by":"publisher","DOI":"10.1007\/s10557-020-07116-4"},{"key":"ref10\/cit10","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCRESAHA.118.312439"},{"key":"ref11\/cit11","doi-asserted-by":"publisher","DOI":"10.1172\/jci.insight.127652"},{"key":"ref12\/cit12","doi-asserted-by":"publisher","DOI":"10.1080\/14779072.2021.1940958"},{"key":"ref13\/cit13","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCRESAHA.118.313187"},{"key":"ref14\/cit14","doi-asserted-by":"publisher","DOI":"10.1016\/j.yjmcc.2021.09.010"},{"key":"ref15\/cit15","doi-asserted-by":"publisher","DOI":"10.1161\/JAHA.121.023601"},{"key":"ref16\/cit16","doi-asserted-by":"publisher","DOI":"10.1016\/j.atherosclerosis.2011.11.035"},{"key":"ref17\/cit17","doi-asserted-by":"publisher","DOI":"10.1074\/mcp.M112.021873"},{"key":"ref18\/cit18","doi-asserted-by":"publisher","DOI":"10.1016\/j.jjcc.2016.05.007"},{"key":"ref19\/cit19","doi-asserted-by":"publisher","DOI":"10.1161\/JAHA.120.016715"},{"key":"ref20\/cit20","doi-asserted-by":"publisher","DOI":"10.1161\/ATVBAHA.122.317953"},{"key":"ref21\/cit21","doi-asserted-by":"publisher","DOI":"10.3389\/fphys.2022.934941"},{"key":"ref22\/cit22","doi-asserted-by":"publisher","DOI":"10.3390\/biomedicines9040439"},{"key":"ref23\/cit23","doi-asserted-by":"publisher","DOI":"10.1038\/nmeth.1322"},{"key":"ref24\/cit24","doi-asserted-by":"publisher","DOI":"10.1074\/mcp.M700239-MCP200"},{"key":"ref25\/cit25","doi-asserted-by":"publisher","DOI":"10.1021\/pr800362h"},{"key":"ref26\/cit26","doi-asserted-by":"publisher","DOI":"10.1021\/pr5007284"},{"key":"ref27\/cit27","doi-asserted-by":"publisher","DOI":"10.1093\/bioinformatics\/bty815"},{"key":"ref28\/cit28","doi-asserted-by":"publisher","DOI":"10.1021\/pr4006958"},{"key":"ref29\/cit29","doi-asserted-by":"publisher","DOI":"10.1074\/mcp.M115.055905"},{"key":"ref30\/cit30","doi-asserted-by":"publisher","DOI":"10.3390\/ijms21113743"},{"key":"ref31\/cit31","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.120.046528"},{"key":"ref32\/cit32","doi-asserted-by":"publisher","DOI":"10.1038\/nature08467"},{"key":"ref33\/cit33","doi-asserted-by":"publisher","DOI":"10.1101\/cshperspect.a012716"},{"key":"ref34\/cit34","doi-asserted-by":"publisher","DOI":"10.1016\/j.mrfmmm.2008.12.006"},{"key":"ref35\/cit35","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCIMAGING.112.973370"},{"key":"ref36\/cit36","doi-asserted-by":"publisher","DOI":"10.1007\/s00109-012-0942-8"},{"key":"ref37\/cit37","doi-asserted-by":"publisher","DOI":"10.1002\/path.4534"},{"key":"ref38\/cit38","doi-asserted-by":"publisher","DOI":"10.1080\/13506129.2019.1625323"},{"key":"ref39\/cit39","doi-asserted-by":"publisher","DOI":"10.1161\/ATVBAHA.113.302175"},{"key":"ref40\/cit40","doi-asserted-by":"publisher","DOI":"10.1155\/2019\/9613090"},{"key":"ref41\/cit41","doi-asserted-by":"publisher","DOI":"10.5114\/ceji.2020.101271"},{"key":"ref42\/cit42","doi-asserted-by":"publisher","DOI":"10.1007\/978-981-13-3681-2_9"},{"key":"ref43\/cit43","doi-asserted-by":"publisher","DOI":"10.1080\/21541248.2016.1211398"},{"key":"ref44\/cit44","doi-asserted-by":"publisher","DOI":"10.1152\/physrev.00021.2012"},{"key":"ref45\/cit45","doi-asserted-by":"publisher","DOI":"10.1016\/j.atherosclerosis.2018.02.007"},{"key":"ref46\/cit46","doi-asserted-by":"publisher","DOI":"10.7554\/eLife.02443"},{"key":"ref47\/cit47","doi-asserted-by":"publisher","DOI":"10.1098\/rsob.170204"},{"key":"ref48\/cit48","doi-asserted-by":"publisher","DOI":"10.4161\/cbt.11.6.14412"},{"key":"ref49\/cit49","doi-asserted-by":"publisher","DOI":"10.1369\/0022155412456380"},{"key":"ref50\/cit50","doi-asserted-by":"publisher","DOI":"10.1111\/febs.14791"},{"key":"ref51\/cit51","doi-asserted-by":"publisher","DOI":"10.2119\/molmed.2017.00067"},{"key":"ref52\/cit52","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCRESAHA.122.320781"},{"key":"ref53\/cit53","doi-asserted-by":"publisher","DOI":"10.1172\/jci.insight.142339"},{"key":"ref54\/cit54","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.104.511717"},{"key":"ref55\/cit55","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbapap.2014.03.015"},{"key":"ref56\/cit56","doi-asserted-by":"publisher","DOI":"10.31083\/j.fbl2710291"},{"key":"ref57\/cit57","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2011-10-387464"},{"key":"ref58\/cit58","doi-asserted-by":"publisher","DOI":"10.3389\/fcvm.2021.652852"},{"key":"ref59\/cit59","doi-asserted-by":"publisher","DOI":"10.1161\/ATVBAHA.113.301327"},{"key":"ref60\/cit60","doi-asserted-by":"publisher","DOI":"10.3389\/fphar.2020.603322"},{"key":"ref61\/cit61","doi-asserted-by":"publisher","DOI":"10.1186\/s13098-021-00631-w"},{"key":"ref62\/cit62","doi-asserted-by":"publisher","DOI":"10.1016\/j.atherosclerosis.2018.09.037"},{"key":"ref63\/cit63","doi-asserted-by":"publisher","DOI":"10.3389\/fgene.2012.00247"},{"key":"ref64\/cit64","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0510346103"},{"key":"ref65\/cit65","doi-asserted-by":"publisher","DOI":"10.1161\/ATVBAHA.122.317643"},{"key":"ref66\/cit66","doi-asserted-by":"publisher","DOI":"10.1016\/j.yjmcc.2015.07.005"},{"key":"ref67\/cit67","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijcard.2015.05.001"},{"key":"ref68\/cit68","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehu281"},{"key":"ref69\/cit69","doi-asserted-by":"publisher","DOI":"10.3390\/genes12030387"},{"key":"ref70\/cit70","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gkab1038"}],"container-title":["Journal of Proteome Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/pubs.acs.org\/doi\/pdf\/10.1021\/acs.jproteome.3c00649","content-type":"application\/pdf","content-version":"vor","intended-application":"unspecified"},{"URL":"https:\/\/pubs.acs.org\/doi\/pdf\/10.1021\/acs.jproteome.3c00649","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,8,2]],"date-time":"2024-08-02T11:55:58Z","timestamp":1722599758000},"score":1,"resource":{"primary":{"URL":"https:\/\/pubs.acs.org\/doi\/10.1021\/acs.jproteome.3c00649"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,4,10]]},"references-count":70,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2024,8,2]]}},"alternative-id":["10.1021\/acs.jproteome.3c00649"],"URL":"https:\/\/doi.org\/10.1021\/acs.jproteome.3c00649","relation":{},"ISSN":["1535-3893","1535-3907"],"issn-type":[{"value":"1535-3893","type":"print"},{"value":"1535-3907","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,4,10]]}}}